The price of internship through COVID-19: 1st year physicians report substantial mental health symptoms during the pandemic.

Objectives: To examine the prevalence of mental health symptoms among medical interns working for the first time as physicians in a large tertiary hospital in Israel during the 1st COVID year.

Methods: All interns who worked for at least 2 months during the 1st COVID year (March 2020-February 2021) at the Tel-Aviv Sourasky Medical Center (TASMC), a large tertiary general hospital in Israel were approached simultaneously during April-May 2021, and were requested to fill in an online survey. In each questionnaire, the interns were asked to refer to the worst time they endured the symptoms described.

The Effects of the 1 National COVID 19 Lockdown on Emergency Psychiatric Visit Trends in a Tertiary General Hospital in Israel.

Objective: To examine whether the 1 COVID-19 lockdown in Israel affected emergency psychiatric presentations in a general hospital.

Method: We studied files of patients who underwent psychiatric consultation in the emergency-room (ER) at the Tel-Aviv Sourasky Medical Center during a lockdown imposed in 2020. Parallel data were obtained from 2017-2019, as control.

Inducing a Functional-Pharmacological Coupling in the Human Brain to Achieve Improved Drug Effect.

Neuropharmacotherapy is substantially hindered by poor drug targeting, resulting in low specificity and efficacy. It is known that different behavioral tasks increase functional activity and cerebral blood flow (CBF), two key parameters controlling drug delivery and efficacy. Here, we tested a novel, non-invasive drug targeting approach (termed functional-pharmacological coupling), which couples drug administration with a task that is known to specifically activate the drug's sites-of-action in the brain.

Modulating Emotional Experience Using Electrical Stimulation of the Medial-Prefrontal Cortex: A Preliminary tDCS-fMRI Study.

Objectives: Implicit regulation of emotions involves medial-prefrontal cortex (mPFC) regions exerting regulatory control over limbic structures. Diminished regulation relates to aberrant mPFC functionality and psychopathology. Establishing means of modulating mPFC functionality could benefit research on emotion and its dysregulation.