Publications by authors named "Roy S Rubinfeld"
Article Synopsis
- The study evaluated the effects of "epi-on" corneal crosslinking on visual acuity in patients diagnosed with keratoconus through a multicenter trial with randomized treatment groups.
- About 2,228 subjects were treated, with significant visual acuity improvements noted at both 6 and 12 months post-treatment, specifically in corrected and uncorrected distance visual acuity, as well as corneal curvature.
- The procedure was well-tolerated, with only a small percentage (8.7%) experiencing mild adverse events, and no serious complications reported, indicating a strong safety and efficacy profile for the treatment.
Article Synopsis
- - The study aimed to evaluate changes in corneal thickness (pachymetry) after a new epithelium-on crosslinking (CXL) procedure called EpiSmart.
- - A total of 101 eyes were analyzed at multiple time points (baseline, 3, 6, and 12 months post-CXL), showing no significant changes in thickness with measurements remaining stable around 450 microns throughout the study.
- - The conclusion indicated that the EpiSmart CXL procedure did not result in significant corneal thinning over a year, as confirmed by the measurements taken.
Purpose: To evaluate effects of sodium iodide (NaI) on riboflavin concentration in corneal stroma before and during ultraviolet A (UVA) light exposure using a novel transepithelial corneal collagen crosslinking (CXL) procedure (EpiSmart CXL system, CXL Ophthalmics, Encinitas CA).
Methods: Riboflavin solutions with NaI (Ribostat, CXL Ophthalmics, Encinitas CA) and without NaI were used for CXL in rabbits using EpiSmart. A pilot study determined sufficient riboflavin loading time.
Purpose: To assess the effectiveness of a novel treatment for patients with advanced corneal ectasia and loss of visual acuity (VA). Conductive keratoplasty (CK) is performed to improve VA followed by epithelium-on (epi-on) corneal crosslinking (CXL) to stabilize the cornea after CK.
Methods: Retrospective, exploratory cohort study.
Purpose: There has been a recent explosion in the variety of techniques used to accomplish corneal cross-linking (CXL) for the treatment of ectatic corneal diseases. To understand the success or failure of various techniques, we review the physicochemical basis of corneal CXL and re-evaluate the current principles and long-standing conventional wisdom in the light of recent, compelling, and sometimes contradictory research.
Methods: Two clinicians and a medicinal chemist developed a list of current key topics, controversies, and questions in the field of corneal CXL based on information from current literature, medical conferences, and discussions with international practitioners of CXL.
Purpose: To report diffuse lamellar keratitis (DLK) occurring in an eye that underwent epithelium-off (epi-off) corneal cross-linking (CXL) as a treatment for post-surgical ectasia and the successful treatment of progressive ectasia with a novel epi-on CXL and conductive keratoplasty (CK) treatment.
Observations: A 42-year-old man presented with corneal ectasia in his right eye 3 years after laser in situ keratomileusis (LASIK) surgery. He underwent epi-off corneal CXL using the Dresden protocol.
Purpose: To evaluate the effect of riboflavin-ultraviolet (UV)-A corneal crosslinking (CXL) without epithelial removal on ectatic corneal disease.
Setting: Woolfson Eye Institute, Atlanta, Georgia, USA.
Design: Prospective observational study.
Quantitative analysis of corneal stromal riboflavin concentration without epithelial removal.
J Cataract Refract Surg
February 2018
Purpose: To compare the corneal stromal riboflavin concentration and distribution using 2 transepithelial corneal crosslinking (CXL) systems.
Setting: Absorption Systems, San Diego, California, USA.
Design: Experimental study.
A 41-year-old man presented 10 years after uneventful laser in situ keratomileusis (LASIK) with symptomatic post-LASIK ectasia. He had treatment with the classic Dresden epithelium-off technique and presented 4 years later with progression of the ectasia. He was subsequently retreated with conductive keratoplasty (CK) followed by a new proprietary epithelium-on corneal collagen crosslinking (CXL) procedure using a proprietary transepithelial riboflavin formulation and delivery system on the following day.
View Article and Find Full Text PDFPurpose: To elucidate risk factors, clinical course, visual outcomes, and treatment of culture-proven methicillin-resistant Staphylococcus aureus (MRSA) infectious keratitis following refractive surgery.
Design: Interventional case series.
Methods: Multicenter chart review of 13 cases of MRSA keratitis following refractive surgery and literature review.
Purpose: To describe a novel topographic curvature pattern, vertical D, which was present in some keratoconus suspects. This pattern was detected retrospectively in 2 patients who developed post-LASIK ectasia and prospectively in 4 patients who had other corneal abnormalities suggestive of keratoconus.
Design: Retrospective interventional case series and prospective cross-sectional study.
Purpose: To report serious complications caused by recutting laser in situ keratomileusis (LASIK) flaps for enhancement and reconsider the current preferred method of LASIK enhancement.
Setting: Multiple surgeon practices.
Methods: This retrospective noncomparative nonconsecutive case series comprised LASIK patients in the private practices of 9 experienced refractive surgeons and those reported in a survey of refractive surgeons.
Objective: To examine the histologic and ultrastructural features of human corneas after successful laser in situ keratomileusis (LASIK) in 2 patients post mortem.
Methods: Portions of 4 corneas were processed for histology, transmission electron microscopy, and scanning electron microscopy.
Results: Case 1 had undergone LASIK 3 months prior to death and case 2 had undergone LASIK 20 months prior to death.