Metab Syndr Relat Disord
August 2016
Background: The prevalence of obesity is increasing in young people in the United States. Lately, low-grade inflammation is recognized as accompanying obesity, a known risk factor for type 2 diabetes. Autonomic dysfunction is a prominent feature of adult diabetes, but its prevalence in adolescents in prediabetic states or with diabetes risk factors is unknown.
View Article and Find Full Text PDFBackground: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. The aims of this study were to provide an estimate of the prevalence of PCOS in clinical practice; compare the risk of established cardiovascular risk factors, cardiovascular disease, and other comorbid conditions in women with PCOS to that of age- and race-matched controls; and explore the total costs of care that can be attributed to PCOS.
Methods: Louisiana Medicaid claims data were used to identify women with PCOS or its defining features and a control group in a ratio of 1:3.
Background: Despite significant advances in pharmacological and nonpharmacological treatment of heart failure (HF), there are more than 1 million HF visits annually to the emergency department. Studies indicate that HF clinical outcome is affected not only by medical interventions but also by social factors such as marital status.
Objectives: This study aimed to determine the effect of marital status of HF patients on clinical outcome of HF in a high-risk population.
The long-term effects of illicit drug use (IDU) on the clinical outcome of patients with heart failure (HF) are not well described. The objective of the present study was to describe the characteristics of patients with HF who used illicit drugs and to determine the effects of IDU on the clinical outcomes such as in-hospital mortality and hospital readmission for HF. A retrospective cohort study was conducted that included all patients admitted with HF from June 2003 to September 2004 and followed up until 2008 at a university hospital serving an at-risk population.
View Article and Find Full Text PDFBackground: Metabolic syndrome is a collection of anthropomorphic and metabolic derangements that, taken together, constitute a strong predictor of stroke, cardiovascular disease, type 2 diabetes, and perhaps other disorders. Diagnosing the metabolic syndrome according to presently accepted definitions requires a mixture of anthropomorphic and laboratory measurements. In indigent patient populations or locations that lack adequate laboratory facilities, a noninvasive low-cost or cost-free alternative would be beneficial as a preliminary screening measure.
View Article and Find Full Text PDFJ Pediatr Pharmacol Ther
April 2010
Objectives: To formulate a liquid preparation of ziprasidone in a convenient concentration to allow dosing of less than 20 mg and of sufficient chemical and physical stability to enable an entire prescription or course of treatment to be prepared in a single batch.
Methods: Geodon for injection (ziprasidone mesylate), 20 mg/mL, was diluted to 2.5 mg/mL in a commercially available sugar-free and alcohol-free, flavored syrup and stored at room temperature under ambient fluorescent light illumination, at room temperature in darkness, and under refrigeration.
Int J Pharm Compd
February 2015
A high-performance liquid chromatographic assay method was developed to facilitate stability studies of extemporaneously compounded oral liquid formulations of ziprasidone. The method is simple and precise within the needs of the pharmaeutical profession. The throughput time is approximately 7 minutes per sample.
View Article and Find Full Text PDFBackground: Metabolic syndrome (MS) represents a cluster of cardiovascular risk factors that includes hypertriglyceridemia. Although low-density lipoprotein (LDL) cholesterol is the critical therapeutic target in patients with coronary artery disease, LDL cannot be calculated in those with excessive hypertriglyceridemia. Non-high-density lipoprotein (HDL) does not require LDL for calculation and may be an alternative therapeutic target in MS.
View Article and Find Full Text PDFObjective: To summarize findings regarding the association of inflammatory processes with chronic heart failure (HF).
Data Sources: We conducted PubMed/MEDLINE searches (1966-January 2008) of primary literature using the following key words: ACE inhibitors, allopurinol, angiotensin-receptor antagonists, cardiomyopathy, chemokines, cytokines, diuretics, heart failure, inflammation, interleukins, HMG-CoA reductase inhibitors, immunotherapy, medications used in heart failure, thalidomide, tumor necrosis factor, and uric acid.
Study Selection And Data Extraction: All articles that appeared to be relevant were read; of 305 articles examined, 87 were selected for discussion.
Objective: To review recent advances in the prevention of venous thromboembolism (VTE) in acutely ill nonsurgical inpatients.
Data Sources: A MEDLINE search (1966-March 2005) was done to identify relevant articles relating to prevention of VTE in acutely ill nonsurgical inpatients.
Study Selection And Data Extraction: Four major prophylaxis trials, one registry, one guideline, and supporting articles representative of the subject matter from the last few years were included.