Publications by authors named "Roy Martin Roop"
Article Synopsis
- MucR is a transcriptional regulator found in Brucella species that influences gene expression related to virulence by binding to AT-rich DNA regions.
- MucR is part of the Ros/MucR family in α-proteobacteria and shares functional similarities with H-NS proteins, although they lack sequence homology.
- This study uses cryo-EM and other methods to reveal that MucR and its homolog Ml5 form a unique circular structure that can condense DNA, linking nucleoid structure to transcription regulation.
Article Synopsis
- MucR is part of a protein family that plays a crucial role in regulating virulence and symbiosis genes in α-proteobacteria.
- Recent research has redefined MucR from a classical transcriptional regulator to a unique Histone-like Nucleoid Structuring (H-NS) protein.
- The review aims to compile genetic and biochemical evidence showing that MucR binds to AT-rich DNA regions, influencing gene expression differently than traditional regulators.
MucR is a member of the Ros/MucR family of prokaryotic zinc-finger proteins found in the α-proteobacteria which regulate the expression of genes required for the successful pathogenic and symbiotic interactions of these bacteria with the eukaryotic hosts. The structure and function of their distinctive zinc-finger domain has been well-studied, but only recently the quaternary structure of the full length proteins was investigated demonstrating their ability to form higher-order oligomers. The aim of this study was to identify the region of MucR involved in higher-order oligomer formation by analysing deletion and point mutants of this protein by Light Scattering, and to determine the role that MucR oligomerization plays in the regulatory function of this protein.
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