Publications by authors named "Roy Hoffmans"
A novel, palatable butyric acid-rich triglyceride oil has been developed and is available as a food supplement for adults in the United States and Canada. A program of safety studies was conducted with butyric acid-rich triglyceride oil for the pediatric population. The oil was tested in a microbial reverse mutation assay Ames Test OECD471 (Organisation for Economic Co-operation and Development) in which all bacterial strains showed negative responses over the complete dose range in two independently repeated experiments.
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- Lacto-N-tetraose (LNT) is a type of sugar found in human breast milk, with concentrations varying throughout lactation.
- A study tested the safety of LNT produced by E. coli K-12 E2083, finding no genotoxic effects in key assays and no adverse effects in a 90-day oral toxicity study on rats.
- The highest safe dietary level of LNT was determined to be 5% (w/w), suggesting it is safe for use as a food ingredient, corroborated by data from other LNT batches.