[Inappropriate eating habits are associated with hypercholesterolemia in adolescents].

Background: Lifestyle changes in adolescents are characterized by a poor diet which means rich in fat and cholesterol, and it is associated with the development of dyslipidemia, which is considered one of the main risk factors for cardiovascular disease in adulthood.

Objective: To identify the association between risk eating habits and the presence of dyslipidemia in adolescents at the primary health care level.

Material And Methods: Cross-sectional, analytical, and retrospective study, which included adolescents aged 10-17 years.

[Asthma as a Protective Factor Against Mortality in Mexican Population with COVID-19].

Background: SARS-CoV-2 infection associated with the presence of comorbidities increased the risk of mortality. However, the role of asthma as a predictor of mortality and severity has not been defined.

Aim: To assess the impact of asthma as a factor associated with the decrease in mortality in the Mexican population with COVID-19.

Tryptophan fuels MYC-dependent liver tumorigenesis through indole 3-pyruvate synthesis.

Cancer cells exhibit distinct metabolic activities and nutritional dependencies compared to normal cells. Thus, characterization of nutrient demands by individual tumor types may identify specific vulnerabilities that can be manipulated to target the destruction of cancer cells. We find that MYC-driven liver tumors rely on augmented tryptophan (Trp) uptake, yet Trp utilization to generate metabolites in the kynurenine (Kyn) pathway is reduced.

[Numerical expression of the clinical course of the disease. Data management].

Data management "behind the scenes" refers to collection, cleaning, imputation, and demarcation; and despite of being indispensable processes, they are usually neglected and thus, generate erroneous information. During the collection are errors: omission of covariates, deviation from the objective, and insufficient quality. The omission of covariates distorts the result attributed to the main manoeuvre.

[ROC curves: general characteristics and their usefulness in clinical practice].

The use of diagnostic tests to determine the presence or absence of a disease is essential in clinical practice. The results of a diagnostic test may correspond to numerical estimates that require quantitative reference parameters to be transferred to a dichotomous interpretation as normal or abnormal and thus implement actions for the care of a condition or disease. For example, in the diagnosis of anemia it is necessary to define a cut-off point for the hemoglobin variable and create two categories that distinguish the presence or absence of anemia.

[Factors associated with benzodiazepines dependence in insomnia patients].

Background: The use of benzodiazepines as a treatment for insomnia can have side effects such as impaired coordination causing falls in adults and even dependence.

Objective: To assess the factors associated with dependence on benzodiazepines in patients with insomnia.

Methods: Observational, cross-sectional, prospective, and analytical study, at the first level of care.

[Severe post-COVID-19 dialysis dependence and inpatient acute kidney injury].

Background: COVID-19 challenged our health system, within the broad clinical spectrum acute kidney injury was presented as a catastrophic event, acute kidney injury and the risk of dependency after dialysis constitute a clinical problem with high repercussions in the funcionality.

Objective: To identify risk factors for dialysis dependence after acute kidney injury from COVID-19.

Material And Methods: A retrospective observational cohort study was carried out at the Hospital de Especialidades del Centro Médico Nacional Siglo XXI, of the Mexican Institute of Social Security, from March 2020 to March 2021.

[Comment on article "Risk factors associated with preterm birth in a second level hospital"].

Preterm birth is a worldwide problem with a high economic impact and morbimortality in children. Therefore, the literature has focused on finding modifiable factors associated with this entity, such as the study "Risk factors associated with preterm birth in a second level hospital," which concluded that "100% of risk factors associated with preterm birth are potentially preventable". Our team reanalyzed the results and found in the regression model that premature rupture of membranes was the only variable associated with preterm birth.

Resource theory of quantum scrambling.

Quantum chaos has become a cornerstone of physics through its many applications. One trademark of quantum chaotic systems is the spread of local quantum information, which physicists call scrambling. In this work, we introduce a mathematical definition of scrambling and a resource theory to measure it.

Risk Assessment of Dyslipidemias, Hyperglycemia, Hyperuricemia, and Hypertension Utilizing Self-Reported Body Silhouettes.

Objective: Self-reported body silhouette is an anthropometric instrument that has been utilized as a screening tool for underweight, overweight, obesity, and other abnormal anthropometric variables. Herein, we analyzed the risk associated with the self-reported body silhouette in the scope of dyslipidemias, hyperglycemia, hyperuricemia, and hypertension.

Methods: Adult participants of the Health Workers Cohort Study enrolled between March 2004 and April 2006 were included.

[Diagnostic performance of the FINDRISC questionnaire to identify insulin resistance in adults].

Background: Insulin resistance (IR) is a state prior to the development of type 2 diabetes (T2D) and it is reversible with lifestyle modification. However, it is underdiagnosed due to the difficulty in its measurement.

Objective: To evaluate the diagnostic performance of the FINDRISC questionnaire to identify IR.

The AHR target gene scinderin activates the WNT pathway by facilitating the nuclear translocation of β-catenin.

The ligand-activated transcription factor aryl hydrocarbon receptor (AHR) regulates cellular detoxification, proliferation and immune evasion in a range of cell types and tissues, including cancer cells. In this study, we used RNA-sequencing to identify the signature of the AHR target genes regulated by the pollutant 2,3,7,8-tetrachlorodibenzodioxin (TCDD) and the endogenous ligand kynurenine (Kyn), a tryptophan-derived metabolite. This approach identified a signature of six genes (CYP1A1, ALDH1A3, ABCG2, ADGRF1 and SCIN) as commonly activated by endogenous or exogenous ligands of AHR in multiple colon cancer cell lines.

Tryptophan and its metabolites in normal physiology and cancer etiology.

Within the growing field of amino acid metabolism, tryptophan (Trp) catabolism is an area of increasing interest. Trp is essential for protein synthesis, and its metabolism gives rise to biologically active catabolites including serotonin and numerous metabolites in the kynurenine (Kyn) pathway. In normal tissues, the production of Trp metabolites is directly regulated by the tissue-specific expression of Trp-metabolizing enzymes.

Self-reported body silhouettes: a diagnostic instrument for anthropometric parameters.

Objective: Routine body size measurement of anthropometric values requires professionals, standardized techniques, and calibrated tools. Therefore, there is a need for easier screening tools such as the self-reported body silhouette (Self-bosi). The aim of this study was to analyze the performance of Self-bosi as a proxy of anthropometric values.

Risk factors associated with SARS-CoV-2 pneumonia in the pediatric population.

IntroducciÓn: Hasta ahora existen pocos estudios sobre las características clínicas de la población pediátrica con neumonía por COVID-19. El objetivo de este estudio fue analizar los datos que se asocian con el desarrollo de neumonía en niños y adolescentes con infección por SARS-CoV-2 en México.

MÉtodos: Se llevó a cabo un análisis secundario de la base de datos de la Dirección General de Epidemiología del Gobierno Mexicano.

[The relevance and irrelevance of charts in clinical research].

Charts are a visual aid that is used in articles in order to highlight the results of an investigation. They allow illustrating the results with the purpose of making them clearer. Charts, just like statistical tests, are selected based on the objective of the study, the types of variable, and the statistical analyzes to be illustrated.

Back to the clinic. Methods II. The Architecture of Clinical Research. Subject interaction, maneuvers and disease throughout time.

Medicine is characterized by the application of the scientific method through clinical judgment, by correct interpretation and use of the clinical course and/or natural history of the disease; its best description is observed in the architecture of clinical research. Through a temporal sequence, this model explains the phenomenon of causality with three sections: baseline status, maneuver, and outcome. The baseline status assesses who the patient is, where does he come from, his general conditions, the diagnosis, stage and aggressiveness of the pathology, complications, previous therapies, socioeconomic-cultural level, habits, therapeutic indications or contraindications, and the expected evolution is anticipated.

Height and weight progression patterns in Mexican children aged between 6 and 12 years and differences with Ramos-Galván growth charts 40 years later.

Introduction: Children and adolescents weight and height are a reflection of the health status and socioeconomic development of a population.

Objective: To evaluate height and weight progression patterns of Mexican children and compare them with Dr. Ramos-Galván growth charts 40 years later.

[List of Ethical Principles for Medical Research Involving Human Subjects].

The ethical principles of a research proposal are not contained only in a paragraph or in the informed consent form; actually, they are an essential part of the whole protocol from the beginning to the end. In a complementary manner to the regulatory and educative documents, our objective in this article is to propose a checklist of questions so researches can ensure they have included the necessary information and precautions to meet the ethical considerations that are required for every research with human beings, which shall be called List of Ethical Principles for Medical Research Involving Human Subjects. We propose questions that researchers must ask themselves when they compose the background, justification, objectives, research question, hypothesis, selection criteria, sample size calculation, sampling, research design, statistical analysis plan, ethical aspects, publication plan, and references.

Co-transmission of Related Malaria Parasite Lineages Shapes Within-Host Parasite Diversity.

In high-transmission regions, we expect parasite lineages within complex malaria infections to be unrelated due to parasite inoculations from different mosquitoes. This project was designed to test this prediction. We generated 485 single-cell genome sequences from fifteen P.

Factors associated with death in children with COVID-19 in Mexico.

Introduction: Most children affected by SARS-CoV-2 are reported to be asymptomatic, and COVID-19-related mortality in them is low; in Mexico, there is a lack of information on the subject in this population group.

Objective: To assess the risk factors associated with mortality in Mexican children with COVID-19.

Method: Secondary analysis of the General Directorate of Epidemiology database.

Education with a multimedia web platform improves knowledge and HbA1c of Mexican patients with type 2 diabetes. Open clinical trial.

Introduction: The patient with diabetes mellitus type requires to receive education about the disease aimed at improving knowledge and skills for their control. The objective of this study is to evaluate the efficacy of nutritional therapy and education through a multimedia site on the level of knowledge and metabolic control in patients with type 2 diabetes.

Patients And Methods: Open-label clinical trial of 12 months of follow-up in 161 patients with type 2 diabetes.

[Correlation: not all correlation entails causality].

The concept of correlation entails having a couple of observations (X and Y), that is to say, the value that Y acquires for a determined value of X; the correlation makes it possible to examine the trend of two variables to be grouped together. We know that, with increasing age, blood pressure figures also increase, therefore, if we want to answer a research question like "what is the connection between age and blood pressure?" the relevant statistical test is a correlation test. This test makes it possible to quantify the magnitude of the correlation between two variables, but it is also helpful for predicting values.