The Small GTPase Ran Increases Sensitivity of Ovarian Cancer Cells to Oncolytic Vesicular Stomatitis Virus.

Ovarian cancer is the deadliest gynecologic cancer, and with the majority of patients dying within the first five years of diagnosis, new therapeutic options are required. The small guanosine triphosphatase (GTPase) Ras-related nuclear protein (Ran) has been reported to be highly expressed in high-grade serous ovarian cancers (HGSOCs) and associated with poor outcomes. Blocking Ran function or preventing its expression were shown to be promising treatment strategies, however, there are currently no small molecule inhibitors available to specifically inhibit Ran function.

Leveraging Shapley Additive Explanations for Feature Selection in Ensemble Models for Diabetes Prediction.

Diabetes, a significant global health crisis, is primarily driven in India by unhealthy diets and sedentary lifestyles, with rapid urbanization amplifying these effects through convenience-oriented living and limited physical activity opportunities, underscoring the need for advanced preventative strategies and technology for effective management. This study integrates Shapley Additive explanations (SHAPs) into ensemble machine learning models to improve the accuracy and efficiency of diabetes predictions. By identifying the most influential features using SHAP, this study examined their role in maintaining high predictive performance while minimizing computational demands.

Genes Associated with the Immune System Affected by Ionizing Radiation and Estrogen in an Experimental Breast Cancer Model.

Breast cancer is a global health issue that, when in the metastasis stage, is characterized by the lack of estrogen receptor-α, the progesterone receptor, and human epidermal growth receptor expressions. The present study analyzed the differential gene expression related to the immune system affected by ionizing radiation and estrogen in cell lines derived from an experimental breast cancer model that was previously developed; where the immortalized human breast epithelial cell line MCF-10F, a triple-negative breast cancer cell line, was exposed to low doses of high linear energy transfer α particle radiation (150 keV/μm), it subsequently grew in the presence or absence of 17β-estradiol. Results indicated that interferon-related developmental regulator 1 gene expression was affected in the estrogen-treated cell line; this interferon, as well as the Interferon-Induced Transmembrane protein 2, and the TNF alpha-induced Protein 6 gene expression levels were higher than the control in the Alpha3 cell line.

The identification of a SARs-CoV2 S2 protein derived peptide with super-antigen-like stimulatory properties on T-cells.

Severe COVID-19 can trigger a cytokine storm, leading to acute respiratory distress syndrome (ARDS) with similarities to superantigen-induced toxic shock syndrome. An outstanding question is whether SARS-CoV-2 protein sequences can directly induce inflammatory responses. In this study, we identify a region in the SARS-CoV-2 S2 spike protein with sequence homology to bacterial super-antigens (termed P3).

AAV-based gene delivery of antimicrobial peptides to combat drug-resistant pathogens.

Antimicrobial peptides (AMPs) have emerged as potential alternatives to conventional antibiotics due to their novelty and multiple mechanisms of action. Because they are peptides, AMPs are amenable to bioengineering and suitable for cloning and expression at large production scales. However, the efficient delivery of AMPs is an unaddressed issue, particularly due to their large size, possible toxicities, and the development of adverse immune responses.

A potential therapeutic strategy by fungal laccase targeting novel binding sites on human cytomegalovirus DNA polymerase.

Human cytomegalovirus (HCMV) is a common herpesvirus that can severely affect transplant recipients, those with AIDS, and newborns. Existing synthetic medications face limitations, including toxicity, processing issues, and viral resistance. As part of this study, the efficacy of the extracellular enzyme laccase isolated from a widely available mushroom (Pleurotus pulmonarius) was compared to that of ganciclovir, a common antiviral, used against HCMV.

Novel α-mangostin derivatives as promising antiviral agents: Isolation, synthesis, and evaluation against chikungunya virus.

Investigations into fruit and vegetable processing residues (FVPRs) offer huge opportunities to discover novel therapeutics against many diseases. In this study, detailed investigation of Garcinia mangostana fruit peel extract led to the isolation and identification of ten known compounds (1-10). Further, a new series of α-mangostin derived sulphonyl piperzines, aryl alkynes and 1,2,3-triazole derivatives were synthesized using Huisgen 1,3-dipolar cyclo-addition reaction ("click" chemistry).

Frequency of Malignancy in Multi-nodular Goiter in a Tertiary Care Hospital.

Historically multi-nodular goiters have been thought of as a benign disease with a low risk of associated malignancy. Recent studies suggested that the incidence of malignancy in patients with MNG is not uncommon. With the aim of determining frequency of malignancy in multi-nodular goiter this cross sectional observational study was done at Mymensingh Medical College Hospital, Mymensingh, Bangladesh from June 2021 to March 2022.

Enhancing the mechanical properties' performances coconut fiber and CDW composite in paver block: multiple AI techniques with a Performance analysis.

The present research incorporates five AI methods to enhance and forecast the characteristics of building envelopes. In this study, Response Surface Methodology (RSM), Support Vector Machine (SVM), Gradient Boosting (GB), Artificial Neural Networks (ANN), and Random Forest (RF) machine learning method for optimization and predicting the mechanical properties of natural fiber addition incorporated with construction and demolition waste (CDW) as replacement of Fine Aggregate in Paver blocks. In this study, factors considered were cement content, natural fine aggregate, CDW, and coconut fibre, while the resulting measure was the machinal properties of the paver blocks.

FOXP3 Transcriptionally Activates Fatty Acid Scavenger Receptor CD36 in Tumour-Induced Treg Cells.

The host immune system is adapted in a variety of ways by tumour microenvironment and growing tumour interacts to promote immune escape. One of these adaptations is manipulating the metabolic processes of cells in the tumour microenvironment. The growing tumour aggressively utilise glucose, its primary energy source available in tumour site, and produce lactate by Warburg effect.

Individualized Cell-Free DNA Monitoring With Chromosomal Junctions for Mesothelioma.

Introduction: The spatially complex nature of mesothelioma and interventions like pleurodesis, surgery, and radiation often complicate imaging-based assessment. Further, cell-free DNA (cfDNA) based monitoring strategies are inadequate for mesothelioma, given the presence of a few recurring nonsynonymous somatic variants. However, patient-specific chromosomal rearrangements are commonly found in mesothelioma.

Neuropsychiatric complications in chronic kidney disease: Role of gender, clinical, and sociodemographic factors.

Introduction: Patients with chronic kidney disease (CKD) frequently experience neuropsychiatric conditions, such as depression, anxiety, and cognitive impairment, which not only significantly diminish their quality of life, but also contribute to longer hospitalizations, poor treatment adherence, and increased mortality. This hospital-based cross-sectional study aimed to investigate neuropsychiatric complications in CKD patients, focusing on gender differences, and clinical and other sociodemographic factors.

Materials And Methods: Diagnosis of CKD was based on the Kidney Disease: Improving Global Outcomes (KDIGO) criteria, and patients aged 18 years or above were included.

Reliability and applicability of angiographic outcome scales in WEB device-treated aneurysms: a systematic review.

Purpose: Various angiographic assessment scales have been used to report the results of endovascular treatment with the WEB device. We aimed to review the use and reliability of these scales.

Methods: We systematically reviewed studies reporting angiographic outcomes of WEB-treated aneurysms from January 2010 to May 2023.

Investigation of the gastric digestion behavior of commercial infant formulae using an dynamic infant digestion model.

The gastric digestion behavior of different commercial Stage 1 infant formulae (for 0-6 months) with different formulation backgrounds was investigated using an dynamic infant human gastric simulator (iHGS). The microstructural arrangements of the protein and lipid, colloidal stability and protein hydrolysis during digestion were elucidated. During gastric digestion, casein-dominant formulations showed a higher extent of aggregation due to their high proportion of casein micelles that underwent coagulation upon acidification and via the action of pepsin.

Flow diversion for the treatment of distal circulation aneurysms: A randomized comparison.

Background And Purpose: Flow diversion (FD) has expanded beyond initial indications (proximal carotid artery aneurysms) to include distal circulation aneurysms (on the anterior, middle, or posterior cerebral arteries). Our objective was to examine results obtained from aneurysms in these locations in the Flow Diversion in the Treatment of Intracranial Aneurysms Trial (FIAT) which compared FD with alternative standard management options (ASMO).

Materials And Methods: FIAT was an all-inclusive parallel-group 1:1 randomized study comparing FD with one of 4 ASMOs (coiling +/-stenting, parent vessel occlusion (PVO), clipping, or observation, pre-specified by clinical judgment).

Herbal Approaches to Diabetes Management: Pharmacological Mechanisms and Omics-Driven Discoveries.

Diabetes mellitus is a chronic metabolic disorder marked by hyperglycemia, resistance to insulin, and impaired function of the pancreatic β-cells; it advances into more serious complications like nephropathy, neuropathy, cardiovascular disease, and retinopathy; herbal medicine has indicated promise in not just mitigating the symptoms but also in managing the complications. This review would aim to evaluate the pharmacological aspect of the botanical therapies Anacardium occidentale, Allium sativum, Urtica dioica, and Cinnamomum zeylanicum, as well as their bioactive phytochemicals, quercetin, resveratrol, berberine, and epigallocatechin gallate (EGCG). In this review, we discuss their mechanisms for secreting the insulin sensitizers, carbohydrate-hydrolyzing enzymes, reduction in oxidative stress and effectiveness against diabetic complications-all through sensitivity to insulin.

Improved Skin Barrier Function Along with Hydration Benefits of Extract, Aesculin, and Schaftoside and LC-HRMS/MS Dereplication of Its Bio-Active Components.

The skin hydration level is a key factor that influences the physical and mechanical properties of the skin. The stratum corneum (SC), the outermost layer of the epidermis, is responsible for the skin's barrier function. In this study, we investigated the role of a unique composition of extract for its ability to activate CD44, a cell-surface receptor of hyaluronic acid, and aquaporin-3, a water-transporting protein, in human keratinocytes (HaCaT).

Metal-Free Electrocatalytic Alkaline Water Splitting by Porous Macrocyclic Proton Sponges.

Macrocycles are unique as they encapsulate and transfer guest molecules or ions and facilitate catalytic processes. Although metalated macrocycles are pivotal in electrocatalytic processes, using metal-free analogs has been rare. Following the strategy of Kanbara et al.

The identification of a SARs-CoV2 S2 protein-derived peptide with super-antigen-like stimulatory properties on T-cells.

Severe COVID-19 can trigger a cytokine storm, leading to acute respiratory distress syndrome (ARDS) with similarities to superantigen-induced toxic shock syndrome. An outstanding question is whether SARS-CoV-2 protein sequences can directly induce inflammatory responses. In this study, we identify a region in the SARS-CoV-2 S2 spike protein with sequence homology to bacterial super-antigens (termed P3).

A Cheaper Alternative to Conventional Mid-urethral Sling Surgery Can Also Have Comparable Obstetric Outcome in the Long Term: A Case Report.

Stress urinary incontinence (SUI) is a common disorder in females, which significantly affects the quality of life in females. There are many consensus that describe the safety of childbearing after surgery for SUI, but still, a large proportion of surgeons worldwide recommend that women should wait to complete childbearing before pursuing surgical treatment for SUI. There is also some opinion that if patients conceive after surgical treatment for SUI, women should be delivered by cesarean section.

Prediction of undernutrition and identification of its influencing predictors among under-five children in Bangladesh using explainable machine learning algorithms.

Background And Objectives: Child undernutrition is a leading global health concern, especially in low and middle-income developing countries, including Bangladesh. Thus, the objectives of this study are to develop an appropriate model for predicting the risk of undernutrition and identify its influencing predictors among under-five children in Bangladesh using explainable machine learning algorithms.

Materials And Methods: This study used the latest nationally representative cross-sectional Bangladesh demographic health survey (BDHS), 2017-18 data.