CXCL1 activates TRPV1 via Gi/o protein and actin filaments.

Aims: CXCL1 is a chemokine with pleiotropic effects, including pain and itch. Itch, an unpleasant sensation that elicits the desire or reflex to scratch, it is evoked mainly from the skin and implicates activation of a specific subset of IB4+, C-type primary afferents. In previous studies we showed that acute application of CXCL1 induced a Ca influx of low amplitude and slow kinetics in a subpopulation of transient receptor potential vanilloid type 1 (TRPV1)+/isolectin B4 (IB4)+dorsal root ganglia neurons which also responded to other itch-inducing agents.

Effects of arbuscular mycorrhizal fungi on Agrostis capillaris grown on amended mine tailing substrate at pot, lysimeter, and field plot scales.

Applied research programs in the remediation of contaminated areas can be used also for gaining insights in the physiological and ecological mechanisms supporting the resistance of plant communities in stress conditions due to toxic elements. The research hypothesis of this study was that in the heavily contaminated but nutrient-poor substrate of mine tailing dams, the beneficial effect of inoculation with arbuscular mychorrizal fungi (AMF) is due to an improvement of phosphorus nutrition rather than to a reduction of toxic element transfer to plants. A concept model assuming a causal chain from root colonization to element uptake, oxidative stress variables, and overall plant development was used.