Exploring the applicability of a lesion segmentation method on [F]fluorothymidine PET/CT images in diffuse large B-cell lymphoma.

Background And Purpose: The determination of the total metabolic tumour volume based on [F]fluorothymidine ([F]FLT) PET/CT images in diffuse large B-cell lymphoma has a potential clinical value for detecting early relapse in this type of heterogeneous lymphoproliferative tumours. Tumour segmentation is a key step in this process. For this purpose, our objective was to determine a segmentation threshold of [F]FLT PET/CT images, based on a reference tissue uptake, on a cohort of patients with diffuse large B-cell lymphoma (DLBCL) that have been scanned at different stages of the treatment.

[Desmoplastic round cell tumor].

Desmoplastic small round cell tumor is a rare and very aggressive neoplasm that belongs to the family of "small round blue cell tumors". It has a higher incidence in males in the second decade of life. It is due to translocation t(11;22) (p13;q12).

Prospective study on the clinical relevance of F-DOPA positron emission tomography/computed tomography in patients with medullary thyroid carcinoma.

Purpose: F-DOPA Positron Emission Tomography/Computed Tomography (F-DOPA PET/CT) is a sensitive functional imaging method (65-75%) for detecting disease localization in medullary thyroid cancer (MTC). We aimed: (i) to assess the clinical usefulness of F-DOPA PET/CT in patients with MTC and elevated calcitonin (Ctn) and CEA levels and, (ii) to evaluate changes in disease management secondary to the findings encountered with this methodology.

Methods: Thirty-six patients with MTC and Ctn levels ≥150 pg/ml were prospectively included.