Extended use of a progesterone-releasing vaginal ring in nursing women: a phase II clinical trial.

Aim: This study evaluates the performance of extended use of a progesterone (P)-releasing vaginal ring (PVR) in nursing women.

Method: An open-label, noncomparative study on the safety and contraceptive efficacy of PVR replaced every 4 months of use (instead of 3 months) in 192 PVR acceptors. PVR use was initiated at day 59+/-2 (mean+/-SD) postpartum and continued until weaning or completing the use of three PVRs.