Publications by authors named "Rovshan E Gasanov"
Invited for the cover of this issue are Tatiyana Serebryanskaya, Mikhail Kinzhalov and co-workers at St. Petersburg State University, the Research Institute for Physical Chemical Problems, Belarusian State University, Togliatti State University and Blokhin National Medical Research Center of Oncology. The image depicts the shield of Pallas Athena with the structure of a palladium carbene complex that protects against triple-negative breast cancer.
View Article and Find Full Text PDFHydrolytically stable Pd and Pt complexes supported by acyclic diaminocarbene ligands represent a novel class of structural organometallic anticancer agents exhibiting nanomolar antiproliferative activity in a panel of cancer cell lines (IC 0.07-0.81 μM) and up to 300-fold selectivity for cancer cells over normal primary fibroblasts.
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- The study explored the Nicholas cyclization method to synthesize 10-membered benzothiophene-fused heterocyclic enediynes, focusing on different functionalities and identifying its limitations.
- Although cyclization involving oxygen with an ester group produced unstable products, using arenesulfonamide showed higher efficiency, leading to successful formation of 10-membered azaendiynes.
- The resulting enediynes demonstrated moderate anticancer activity against lung cancer cells while causing minimal damage to normal cells, indicating their potential as novel antitumor agents for further development.