Intraoperative tumor lysis syndrome in a giant teratoma: a case report.

Background: Tumor lysis syndrome is an unusual metabolic emergency in solid tumors. Perioperative occurrence of this syndrome is extremely rare but may have fatal consequences if not detected and treated on time.

Case Report: We report a 19-year patient with testicular germ cell tumor after first line chemotherapy with giant growing teratoma syndrome in retroperitoneum.

[Importance of lymphangiogenesis and ultrastructure of lymphatic capillaries in metastasis of malignant melanoma].

Lymphangiogenesis - proliferation of lymphatic capillaries - in melanoma and in its vicinity plays an important role in metastatic process of malign melanoma cells in organism. Melanoma produces epidermal growth factor EGF which induces vascular endothelial growth factor VEGF-C and thereby starts lymphangiogenesis. It is very probable that malignant melanoma cells enter lymphatic capillaries also through specialized inter-endothelial junctions (endothelial microvalves, primary valves) situated in their walls.

[Sentinel lymph node in malignant melanoma].

Melanoma is highly malignant tumor which arises through malignant transformation of melanocytes. Surgical treatment of primary cutaneous melanoma including radical excision and intervention in regional lymphatic drainage is irreplaceable. Sentinel node biopsy is a recognized method of defining the stage of disease.

[Structure and function of lymphatic capillaries in synovial joint].

The review article focuses on the structure and function of lymphatic capillaries in connective tissues of skin, muscles and synovial membrane. Lymphatic capillaries (initial lymphatics) are formed from endothelial cells mutually arranged so that their intercellular junctions have different structure. In one of the different types of intercellular junctions the distal ends of endothelial cells overlap one another in the form of projections.

Treatment of rat adjuvant arthritis with flavonoid (Detralex), methotrexate, and their combination.

In both adjuvant arthritis and rheumatoid arthritis, edema and inflammation appear in synovial joints. Edema or effusion reflects an imbalance in lymph dynamics. Purified micronized flavonoid fraction is mainly used in the treatment of chronic venous insufficiency.

Effects of purified micronized flavonoid fraction (Detralex) on prophylactic treatment of adjuvant arthritis with methotrexate in rats.

Background: In both adjuvant arthritis and rheumatoid arthritis, edema and inflammation appear in synovial joints. Edema or effusion reflects an imbalance in lymph dynamics. Purified micronized flavonoid fraction is mainly used in the treatment of chronic venous insufficiency.

Chondroitin sulphates A, B and C, collagen types I-IV and fibronectin in venous sinus of the red pulp in human spleen.

The morphological relationship of chondroitin sulphates A, B, and C, collagen types I-IV and fibronectin in the wall of venous sinuses of the red pulp in human spleen has not been a focus of interest among morphologists. Regarding the hypothesis that the structure of the spleen lends it the function of a blood filter the substances described in our study might play a significant role in the functional morphology. Of 146 human spleen surgical specimens, groups of 12 specimens each were examined under a light microscope using the method of antibodies against fibronectin, against collagen types I-IV and against chondroitin sulphates A, B, and C.

Structure of synovial lymphatic capillaries in rheumatoid arthritis and juvenile idiopathic arthritis.

The structure of lymphatic capillaries (LC) of the synovial membrane (SM) from patients with rheumatoid arthritis and juvenile idiopathic arthritis obtained by synovectomy was investigated by transmission electron microscopy. This method allows comparison of the structure of the same vessel under light and electron microscope and clear differentiation between lymphatic and blood capillaries and venules. Synovial LC were localized in the subintimal connective tissue of the SM in the vicinity of venules.

Inhibitory effect of enzyme therapy and combination therapy with cyclosporin A on collagen-induced arthritis.

Objective: There is increasing interest in the use of combination therapy for rheumatoid arthritis and in the possibility of combining the conventional drug approach with newer antirheumatic therapy. The present study investigates the efficacy of long-term prophylactic enzyme therapy and combination therapy with cyclosporin A in rats with collagen-induced arthritis.

Methods: Rats with collagen-induced arthritis were administered the following drugs: cyclosporin A (5 mg/kg/day and 10 mg/kg/day orally); a mixture of enzymes containing pure substances (bromelain, trypsin, rutin) in the same ratio as in Phlogenzym (PHL, 150 mg/kg, twice daily intrarectally); and a combination of 5 mg/kg/day cyclosporin A plus 300 mg/kg/day PHL for a period of 50 days from the immunization.

Enzyme and combination therapy with cyclosporin A in the rat developing adjuvant arthritis.

Recent knowledge of the pathophysiology of rheumatoid arthritis and the mechanism of drug effects have enabled the use of new drugs and drug combinations in rheumatoid arthritis therapy. This study investigates the efficacy of both enzyme therapy and combined therapy with cyclosporin in rats with adjuvant arthritis. Rats with adjuvant-induced arthritis were administered either cyclosporin A (2.

[History of knowledge about the structure of renal corpuscles and afferent arterioles].

Some morphological findings obtained during the more than 300-year history of research into the fine structure of the kidney are presented in chronological order (discovery of renal corpuscles and their relationship to kidney arteries, elucidation of topographic relationships between glomeruli and tubules, discovery of specialized structure of juxtaglomerular segments of afferent arterioles). Gradual insight into the structure of the kidney was accompanied by elucidation of its function. Historical knowledge and findings demonstrated on simple drawings were verified in the present study by sophisticated methods of imaging, including transmission and scanning electron microscopy.

[The synovial membrane in chronic juvenile arthritis. Electron microscopy study and case report].

A case report of a patient with juvenile chronic arthritis who underwent early synovectomy of the knee joint is presented. The synovial membrane was examined by light and electron microscopy. The following signs of nonspecific inflammation were observed; lympho-plasmocytic infiltrate in the ground substance of the interstitial connective tissue, increased phagocytic activity of synovial lining cells and macrophages, and neutrophilic granulocytes.

Ultrastructure of renal efferent glomerular arteriole fixed during the infusion of atrial natriuretic peptide (ANP).

The constrictive effect of atrial natriuretic peptide (ANP) on renal efferent glomerular arterioles in anesthetized spontaneously hypertensive rats was visualized by transmission electron microscopy.

Two types of capillaries in the rat renal glomerulus.

Electron-microscopic examination of rats renal glomeruli revealed that Zlábek's thin intercapillary anastomoses (TIAs) are thin vessels which interconnect the ordinary glomerular capillaries, while branching off abundantly. The lumens of the TIAs are irregular, mostly closed, frequently cleft-like; the width of lumens is about 0.9-0.

The effect of native and sonicated double-stranded polyribonucleotides on the course of spontaneous autoimmune disease in NZB and NZB/Swiss F1 mice.

The administration of sonicated fractions of f2 phage polyribonucleotides caused an increased weight loss and deterioration of the clinical state in female NZB mice. Discontinuance of the treatment resulted in an improvement of both the clinical state and the genetically determined autoimmune disorders of these mice. Some potential explanations of this effect are discussed.

Gold nephropathy in rheumatoid arthritis and in juvenile chronic arthritis.

During gold therapy a patient with rheumatoid arthritis developed nephrotic syndrome, and a patient with juvenile chronic arthritis proteinuria. Electron microscopic examination of bioptic specimens of the kidneys revealed in both instances membranous glomerulonephritis with typical epimembranous deposits and intracellular gold inclusions. Immunofluorescent examination performed only in the second patient revealed that the deposits in the wall of the glomerular capillaries contain IgG which suggests an immunocomplex mechanism of the development of the renal disease, induced very probably by chrysotherapy.