A new high spatial density temperature dataset in the Grenoble alpine valley (France) for urban heat island investigation and climate services dedicated to municipalities purposes.

Within the study of the urban heat island (UHI) in Echirolles and Grenoble (France, the eastern part of the alpine arc), two temperature measurement networks have been deployed. The aim is to measure the temperature gradients associated with the UHI in summer. A total of 62 measurement points has been installed in the various neighborhoods on 3-meter-high streetlights, starting in summer 2019.

Targeting CEACAM5-positive solid tumors using NILK-2401, a novel CEACAM5xCD47 κλ bispecific antibody.

Background: Blocking the CD47 "don't eat me"-signal on tumor cells with monoclonal antibodies or fusion proteins has shown limited clinical activity in hematologic malignancies and solid tumors thus far. Main side effects are associated with non-tumor targeted binding to CD47 particularly on blood cells.

Methods: We present here the generation and preclinical development of NILK-2401, a CEACAM5×CD47 bispecific antibody (BsAb) composed of a common heavy chain and two different light chains, one kappa and one lambda, determining specificity (so-called κλ body format).

Tracking the Source of Human Q Fever from a Southern French Village: Sentinel Animals and Environmental Reservoir.

, also known as the causal agent of Q fever, is a zoonotic pathogen infecting humans and several animal species. Here, we investigated the epidemiological context of from an area in the Hérault department in southern France, using the One Health paradigm. In total, 13 human cases of Q fever were diagnosed over the last three years in an area comprising four villages.

Inelastic Neutron Scattering Measurement of the Ground State Tunneling Gap in Tb and Ho Analogues of a Dy Field-Induced Single-Molecule Magnet.

Recent advances in single-molecule magnet (SMM) research have placed great value on interpretation of inelastic neutron scattering (INS) data for rare earth (RE)-containing SMMs. Here, we present the synthesis of several rare earth complexes where combined magnetic and INS studies have been performed, supported by calculations. The reaction of rare earth nitrate salts with 2,2'-bipyridine (2,2'-bpy) and tetrahalocatecholate (XCat, X = Br, Cl) ligands in methanol (MeOH) afforded two new families of compounds [RE(2,2'-bpy)(XCat)(XCatH)(MeOH)] (X = Br and RE = Y, Eu, Gd, Tb, Dy, Ho, Yb for ; X = Cl and RE = Y, Tb, Dy, Ho, and Yb for ).

Pangenomic analysis of unveils new traits in genome architecture.

is the etiological agent of Q fever, a worldwide zoonosis able to cause large outbreaks. The disease is polymorphic. Symptomatic primary infection is named acute Q fever and is associated with hepatitis, pneumonia, fever, and auto-immune complications while persistent focalized infections, mainly endocarditis, and vascular infections, occur in a minority of patients but are potentially lethal.

Elucidation of LMCT Excited States for Lanthanoid Complexes: A Theoretical and Solid-State Experimental Framework.

Photophysical and magnetic properties arising from both ground and excited states of lanthanoid ions are relevant for numerous applications. These properties can be substantially affected, both adversely and beneficially, by ligand-to-metal charge-transfer (LMCT) states. However, probing LMCT states remains a significant challenge in f-block chemistry, particularly in the solid state.

Molecular detection of Coxiella burnetii in aborted bovine fetuses in Brazil.

In the past decade, cases of Q fever have been reported in Brazil. Although the previous report of Coxiella burnetii in humans and animals, the knowledge about the occurrence of this pathogen in livestock in Brazil is scarce. This study aimed to search C.

Covalent Grafting of Ruthenium Complexes on Iron Oxide Nanoparticles: Hybrid Materials for Photocatalytic Water Oxidation.

The present environmental crisis prompts the search for renewable energy sources such as solar-driven production of hydrogen from water. Herein, we report an efficient hybrid photocatalyst for water oxidation, consisting of a ruthenium polypyridyl complex covalently grafted on core/shell nanoparticles a phosphonic acid group. The photoelectrochemical measurements were performed under 1 sun illumination in 1 M KOH.

Evaluation using latent class models of the diagnostic performances of three ELISA tests commercialized for the serological diagnosis of Coxiella burnetii infection in domestic ruminants.

ELISA methods are the diagnostic tools recommended for the serological diagnosis of Coxiella burnetii infection in ruminants but their respective diagnostic performances are difficult to assess because of the absence of a gold standard. This study focused on three commercial ELISA tests with the following objectives (1) assess their sensitivity and specificity in sheep, goats and cattle, (2) assess the between- and within-herd seroprevalence distribution in these species, accounting for diagnostic errors, and (3) estimate optimal sample sizes considering sensitivity and specificity at herd level. We comparatively tested 1413 cattle, 1474 goat and 1432 sheep serum samples collected in France.

Coxiella burnetii in slaughterhouses in Brazil: A public health concern.

Q fever is an important zoonosis, yet it is often neglected and can present large outbreaks, as observed in the Netherlands. In the past few years, cases of Q fever have been described in Brazil; however, the epidemiological situation of Q fever in ruminants, the main reservoir of the pathogen, is unknown in this country. Our study aimed to estimate the prevalence of C.

Diastereoselective Synthesis of Axially Chiral Xylose-Derived 1,3-Disubstituted Alkoxyallenes: Scope, Structure, and Mechanism.

The deprotonation of differently substituted propargyl xylosides with -BuLi/TMEDA followed by protonation with -butanol at -115 °C provided a range of new axially chiral 1,3-disubstituted alkoxyallenes in a diastereoselective way. Numerous reaction parameters such as solvent, temperature, or protonating agent were examined as well as protecting groups on the xyloside moiety and the influence of the substituents on the alkyne part. The configuration of the main diastereoisomer of 3-methyl-1-xyloside-allene was determined for the first time by single-crystal X-ray diffraction analysis and nOe NMR experiments.

A sporadic case of acute Q fever and identification of the animal source of the infection.

Q fever is a zoonosis. Humans are infected through the inhalation of Coxiella burnetii particles that are dispersed into the air from the birth products or faeces of ruminants. Major outbreaks can occur in association with farming activities.

Valence tautomerism and spin crossover in pyridinophane-cobalt-dioxolene complexes: an experimental and computational study.

Compounds [Co(L-NR)(dbdiox)](BPh) (L-NR = N,N'-di-alkyl-2,11-diaza[3.3]-(2,6)pyridinophane, R = iPr (1a), Et (2a); dbdiox = 3,5-di-tert-butyldioxolene) and [M(L-NiPr)(dbdiox)](BPh) (M = Mn (3a), Fe (4a)) have been synthesized and investigated with a view to possible valence tautomeric (VT) or spin crossover (SCO) interconversions. Single crystal X-ray diffraction data for all compounds at 100 or 130 K indicate trivalent metal cations and di-tert-butylcatecholate (dbcat) dioxolene ligands.

Photocatalytic Hydrogen Evolution Driven by a Heteroleptic Ruthenium(II) Bis(terpyridine) Complex.

Since the initial report by Lehn et al. in 1979, ruthenium tris(bipyridine) ([Ru(bpy)]) and its numerous derivatives were applied as photosensitizers (PSs) in a large panel of photocatalytic conditions while the bis(terpyridine) analogues were disregarded because of their low quantum yields and short excited-state lifetimes. In this study, we prepared a new terpyridine ligand, 4'-(4-bromophenyl)-4,4‴:4″,4‴'-dipyridinyl- 2,2':6',2″-terpyridine (Bipytpy) and used it to prepare the heteroleptic complex [Ru(Tolyltpy)(Bipytpy)](PF) (; Tolyltpy = 4'-tolyl-2,2':6',2'-terpyridine).

Slow Magnetic Relaxation in Lanthanoid Crown Ether Complexes: Interplay of Raman and Anomalous Phonon Bottleneck Processes.

The combination of lanthanoid nitrates with 18-crown-6 (18-c-6) and tetrahalocatecholate (X Cat , X=Cl, Br) ligands has afforded two compound series [Ln(18-c-6)(X Cat)(NO )]⋅MeCN (X=Cl, 1-Ln; X=Br, 2-Ln; Ln=La, Ce, Nd, Gd, Tb, Dy). The 18-c-6 ligands occupy equatorial positions of a distorted sphenocorona geometry, whereas the charged ligands occupy the axial positions. The analogues of both series with Ln=Ce, Nd, Tb and Dy exhibit out-of-phase ac magnetic susceptibility signals in the presence of an applied magnetic field, indicative of slow magnetization relaxation.

Nuclear RNA surveillance complexes silence HIV-1 transcription.

Expression from the HIV-1 LTR can be repressed in a small population of cells, which contributes to the latent reservoir. The factors mediating this repression have not been clearly elucidated. We have identified a network of nuclear RNA surveillance factors that act as effectors of HIV-1 silencing.

Seroprevalence of horses to Coxiella burnetii in an Q fever endemic area.

Coxiella burnetii can infect many animal species, but its circulation dynamics in and through horses is still unclear. This study evaluated horse exposure in an area known to be endemic for ruminants and humans. We assessed antibody prevalence in horse serum by ELISA, and screened by qPCR horse blood, ticks found on horses and dust from stables.

Attachment of Coxiella burnetii to the zona pellucida of in vitro produced goat embryos.

Previous work demonstrated that after infection of in vivo derived caprine embryos, Coxiella burnetti (C. burnetii) showed a strong tendency to adhere to the zona pellicida (ZP). To investigate the risk of C.

Estimation of the frequency of Q fever in sheep, goat and cattle herds in France: results of a 3-year study of the seroprevalence of Q fever and excretion level of Coxiella burnetii in abortive episodes.

A study was carried out, from 2012 to 2015, in 10 French départements to estimate the serological prevalence of Q fever and the frequency of abortive episodes potentially related to Coxiella burnetii in a large sample of cattle, sheep and goat herds. The serological survey covered 731 cattle, 522 sheep and 349 goat herds, randomly sampled. The frequency of abortive episodes potentially related to C.

Slow magnetisation relaxation in tetraoxolene-bridged rare earth complexes.

Three families of tetraoxolene-bridged dinuclear rare earth (RE) complexes have been synthesised and characterised, with general formula [((HB(pz))RE)(μ-tetraoxolene)] (HB(pz) = hydrotris(pyrazolyl)borate; tetraoxolene = chloranilate (1-RE), the dianionic form of 2,5-dihydroxy-1,4-benzoquinone (2-RE), or its 3,6-dimethyl analogue (3-RE)). In each case, the bridging tetraoxolene ligand is in the diamagnetic dianionic form and species with selected lanthanoid(iii) ions from Eu(iii) to Yb(iii) have been obtained, as well as the diamagnetic Y(iii) analogues. Use of the 3,6-dimethyl substituted tetraoxolene ligand (Me-dhbq) has also afforded the two byproducts [((HB(pz))(MeOH)(B(OMe))Y)(μ-Medhbq)] (4-Y) and [{((HB(pz))(MeOH)Y)(μ-B(OMe))}(μ-Medhbq)]Cl (5-Y), with the B(OMe) ligands arising from partial decomposition of HB(pz).

Facile One-Pot Synthesis of Ruthenium(II) Quaterpyridine-Based Photosensitizers for Photocatalyzed Hydrogen Production.

We present here the efficient microwave-assisted synthesis and photophysical study of a family of ruthenium(II) complexes of the general formula [Ru(bpy)(qpy)] (where bpy = 2,2'-bipyridine, qpy = 4,4':2',2″:4″,4‴-quaterpyridine, and x = 0, 1, 2 giving compounds 1 = [Ru(bpy)(qpy)], 2 = [Ru(bpy)(qpy)], and 3 = [Ru(qpy)]). Compared to the standard reference, [Ru(bpy)] (τ = 870 ns, Φ = 9.5%), the complexes display longer-lived excited state lifetimes at room temperature (τ: 1 = 1440 ns, 2 = 1640 ns, 3 = 1780 ns) and improved quantum yields (Φ: 1 = 14%, 2 = 19%, 3 = 23%).