High prevalence of heterogeneous mupirocin-resistant Staphylococcus aureus and its molecular characterization.

Background: Mupirocin resistance of methicillin-resistant Staphylococcus aureus (MRSA) was frequently reported, but heterogeneous mupirocin resistance in () was rarely recognized. This study aims to investigate the prevalence of mupirocin heteroresistance among clinical . aureus isolates and its possible molecular mechanism.

Antibioflm effects of extracellular matrix degradative agents on the biofilm of different strains of multi-drug resistant Corynebacterium striatum.

Background: Corynebacterium striatum is a microorganism with an excellent capacity for biofilm production and thus has been correlated with nosocomial transmission and invasive infections. However, little is known about the mechanism of biofilm formation of this commensal pathogen. In this study, we aimed to investigate the biofilm formation abilities of multidrug-resistant Corynebacterium striatum clinical isolates and the roles of extracellular proteins, exopolysaccharides and extracellular DNA in mediating more robust biofilm formation by the isolates of C.

Clonal Diversity, Low-Level and Heterogeneous Oxacillin Resistance of Oxacillin Sensitive MRSA.

Purpose: This study investigates the phenotypic and genotypic resistance features of OS-MRSA clinical isolates and their distinctive sensitivities to oxacillin.

Methods: 1200 clinical isolates of were enrolled in this study. Automated antibiotics susceptibility tests on VITEK-2 and BD Phoenix-100, cefoxitin disc diffusion method, oxacillin broth microdilution method, , and gene detection were performed to identify OS-MRSA.