An MDS Patient with Deletion 20q and a t(9;22)(q34;q11.2): A Case Report and Review of the Literature.

We report a 76-year-old male patient with myelodysplastic syndrome (MDS) with a t(9;22) and deletion 20q only by FISH. Past medical history is significant for prostate cancer status post radiation therapy and a 28-pack-year smoking history. In 2016, the patient developed a DVT and incidentally was found to have a BCR::ABL1 (p210) by PCR analysis (level of 0.

Transcriptome profiling of pediatric extracranial solid tumors and lymphomas enables rapid low-cost diagnostic classification.

Approximately 80% of pediatric tumors occur in low- and middle-income countries (LMIC), where diagnostic tools essential for treatment decisions are often unavailable or incomplete. Development of cost-effective molecular diagnostics will help bridge the cancer diagnostic gap and ultimately improve pediatric cancer outcomes in LMIC settings. We investigated the feasibility of using nanopore whole transcriptome sequencing on formalin-fixed paraffin embedded (FFPE)-derived RNA and a composite machine learning model for pediatric solid tumor diagnosis.

HIV infection and ART exposure affect tumor TCR repertoire of diffuse large B cell lymphoma.

The most common subtype of lymphoma globally, diffuse large B cell lymphoma (DLBCL), is a leading cause of cancer death in people with HIV. The restructuring of the T cell compartment because of HIV infection and antiretroviral therapy (ART) may have implications for modern treatment selection, but current understanding of these dynamic interactions is limited. Here, we investigated the T cell response to DLBCL by sequencing the T cell receptor (TCR) repertoire in a cohort of HIV-negative (HIV-), HIV+/ART-experienced, and HIV+/ART-naive patients with DLBCL.

Safety, efficacy, and affordability of ABVD for Hodgkin lymphoma in Malawi: a prospective cohort study.

Background: ABVD (doxorubicin, bleomycin, vinblastine, and dexamethasone) is a proven, curative regimen for Hodgkin lymphoma (HL). Prospective data describing HL treatment in sub-Saharan Africa are limited. We aimed to fill this knowledge gap, using data from Malawi.

COVID-19 Case Surveillance: Trends in Person-Level Case Data Completeness, United States, April 5-September 30, 2020.

Objectives: To obtain timely and detailed data on COVID-19 cases in the United States, the Centers for Disease Control and Prevention (CDC) uses 2 data sources: (1) aggregate counts for daily situational awareness and (2) person-level data for each case (case surveillance). The objective of this study was to describe the sensitivity of case ascertainment and the completeness of person-level data received by CDC through national COVID-19 case surveillance.

Methods: We compared case and death counts from case surveillance data with aggregate counts received by CDC during April 5-September 30, 2020.

Early Intervention in Mental Health for Adolescents and Young Adults: A Systematic Review.

Objective: The purpose of this systematic review was to describe the evidence for the effectiveness of early intervention to improve and maintain performance in occupations for youths with or at risk for serious mental illness (SMI).

Method: Titles and abstracts of 670 articles were reviewed, 234 were retrieved for full review, and 30 met inclusion criteria.

Results: Moderate to strong evidence supports cognitive remediation (CR) and mixed evidence supports cognitive-behavioral therapy (CBT) as an adjunct modality to improve general functioning.

Sensory characteristics of youth at clinical high risk for psychosis.

Aim: To identify and compare the sensory characteristics of young people at clinical high risk (CHR) for psychosis to those of peers at clinical low risk (CLR), and to national normative data. CHR and CLR participants were recruited from 6 US regions.

Method: A descriptive cohort design was used to analyse baseline data collected as part of the Early Detection and Intervention for the Prevention of Psychosis Program (EDIPPP).

Community engagement research and dual diagnosis anonymous.

Community engagement research is widely discussed but rarely implemented. This article describes the implementation of a community engagement research project on Dual Diagnosis Anonymous, a rapidly spreading peer support program in Oregon for people with co-occurring mental illness and substance use disorders. After three years of discussions, overcoming barriers, and involving several institutions, this grassroots research project has been implemented and is expanding.

First-Person Perspectives on Dual Diagnosis Anonymous (DDA): A Qualitative Study.

Objective: People with dually diagnosed substance abuse and mental illnesses often feel alienated at traditional 12-step meetings, yet they need the peer support provided by such groups. Dual Diagnosis Anonymous (DDA) is a peer-support program specifically for people with co-occurring disorders, which addresses many of the factors that members find alienating about traditional 12-step groups. This study aimed to elicit first-person perspectives on DDA.

Physical therapists' perceptions of sexual boundaries in clinical practice in the United States.

Background: Physical therapists' perceptions of sexual boundaries in clinic settings in the United States have not been studied. Given the magnitude of potential consequences of sexual boundary violations, examination of this topic is imperative.

Objective: The purpose of this study was to describe the perceptions of sexual boundaries among licensed physical therapists in the United States.

Public health surveillance workforce of the future.

Although electronic data systems that monitor for health threats are becoming increasingly automated, human expertise is, and always will be, critical to recognizing potential cases of disease, diagnosing disease, reporting diseases or conditions, analyzing and interpreting data, and communicating results to all stakeholders. For this reason, the nation's health professionals from all disciplines and at all levels are fundamental to sustaining and enhancing public health surveillance capacity.

Disruption of a GATA4/Ankrd1 signaling axis in cardiomyocytes leads to sarcomere disarray: implications for anthracycline cardiomyopathy.

Doxorubicin (Adriamycin) is an effective anti-cancer drug, but its clinical usage is limited by a dose-dependent cardiotoxicity characterized by widespread sarcomere disarray and loss of myofilaments. Cardiac ankyrin repeat protein (CARP, ANKRD1) is a transcriptional regulatory protein that is extremely susceptible to doxorubicin; however, the mechanism(s) of doxorubicin-induced CARP depletion and its specific role in cardiomyocytes have not been completely defined. We report that doxorubicin treatment in cardiomyocytes resulted in inhibition of CARP transcription, depletion of CARP protein levels, inhibition of myofilament gene transcription, and marked sarcomere disarray.

Disability reconsidered: the paradox of physical therapy.

The purposes of this perspective article are: (1) to explore models of disability from the perspective of the academic discipline of disability studies (DS), (2) to consider the paradox of improving functional capacities while valuing disability as diversity, (3) to identify how physical therapy's use of the International Classification of Functioning, Disability and Health (ICF) disablement model intersects with various disability models, and (4) to apply this broader understanding of disability to physical therapist practice, education, and research. The DS literature has been critical of rehabilitation professionals, particularly targeting the medical model of disability. In contrast, advocates for a social model of disability recognize disability as diversity.

The Menu Approach to supported employment for individuals with severe and persistent mental illness: Outcomes in an Oregon community based program.

Objective: The purpose of this study was to determine the vocational outcomes at the Abacus Program, a Menu Approach supported employment program designed to assist individuals with serious mental illness (SMI) achieve competitive employment.

Methods: A summative evaluation method was used to determine the vocational outcomes between the years 2000-2006 at the Abacus Program. Data was gathered from existing Abacus Program records and the Statistical Package for the Social Sciences (SPSS) 15.

Transcription of the C. elegans let-7 microRNA is temporally regulated by one of its targets, hbl-1.

The let-7 family of microRNAs (miRNAs) are important regulators of developmental timing and cell differentiation and are often misexpressed in human cancer. In C. elegans, let-7 controls cell fate transitions from larval stage 4 (L4) to adulthood by post-transcriptionally down-regulating lineage-abnormal 41 (lin-41) and hunchback-like 1 (hbl-1).

Analytical decision-making model for addressing the needs of allied health students with disabilities.

The purposes of this article are to (1) review the literature on students with disabilities (SWD) in higher education with a particular focus on allied health and related professions, and (2) propose an analytical decision-making model for assessing students' needs and providing reasonable accommodations in allied health education. Increasing numbers of SWD are entering higher education, but the rate of success for these students is lower than the rate for their nondisabled peers. A multitude of factors impact SWD, including the direct effects of the disabilities on learning and performing essential functions, academic and clinical faculty knowledge of the impact of disability in educational settings and their experience implementing accommodations, and the impact of legislation and institutional policies on service delivery.

The let-7 family of microRNAs.

The first two known microRNAs (miRNAs), lin-4 and let-7, were originally discovered in the nematode Caenorhabditis elegans and control the timing of stem-cell division and differentiation. let-7 was subsequently found as the first known human miRNA. let-7 and its family members are highly conserved across species in sequence and function, and misregulation of let-7 leads to a less differentiated cellular state and the development of cell-based diseases such as cancer.

Examining pre-retirement and related services offered to service-users with an intellectual disability in Ireland.

The purpose of this study was to describe the pre-retirement and related services offered to service-users with intellectual disability in Ireland. Increasing numbers of service-users with an intellectual disability are living into older adulthood, creating important challenges for services providers. The National Intellectual Disability Database 2007 (NIDD) suggests that the population of service-users with an intellectual disability in the Republic of Ireland is an ageing population.

Patient satisfaction with private physiotherapy for musculoskeletal pain.

Background: Despite emphasis on patient centred healthcare, healthcare professionals have been slow to use validated measurements of patient satisfaction in physiotherapy practice. The aim of this cross sectional survey was to measure patient satisfaction with private physiotherapy in Ireland, for patients with musculoskeletal pain, using a previously validated survey instrument.

Methods: A multidimensional patient satisfaction questionnaire 'PTOPS', which assesses patient satisfaction with outpatient physiotherapy treatment, was translated from American English to European English, and relevant demographic and global satisfaction items were included.

Self- and caregiver-reported experiences of young adults with developmental disabilities.

The purpose of this study was to describe the experiences of young adults with developmental disabilities (DD) who were living in community settings with the aid of government-supported services. Six male and 10 female volunteer subjects (mean age = 24 years) were interviewed and the narrative data were analyzed revealing themes in six categories: (1) Home Life, (2) Relationships, (3) Health and Health Care, (4) Personal Growth and Accomplishments, (5) Occupation, and (6) Transportation. Subjects' most positive experiences were associated with integrated, comprehensive and timely services delivered by knowledgeable and sensitive service providers.

MicroRNAs as potential agents to alter resistance to cytotoxic anticancer therapy.

Tumor cells use preexisting prosurvival signaling pathways to evade the damaging and cytotoxic effects of anticancer agents. Radiation therapy is a primary form of cytotoxic anticancer treatment, but agents that successfully modify the radiation response in vivo are lacking. MicroRNAs (miRNA) are global gene regulators that play critical roles in oncogenesis and have been found to regulate prosurvival pathways.

Historical comparisons of morbidity and mortality for vaccine-preventable diseases in the United States.

Context: National vaccine recommendations in the United States target an increasing number of vaccine-preventable diseases for reduction, elimination, or eradication.

Objective: To compare morbidity and mortality before and after widespread implementation of national vaccine recommendations for 13 vaccine-preventable diseases for which recommendations were in place prior to 2005.

Design, Setting, And Participants: For the United States, prevaccine baselines were assessed based on representative historical data from primary sources and were compared to the most recent morbidity (2006) and mortality (2004) data for diphtheria, pertussis, tetanus, poliomyelitis, measles, mumps, rubella (including congenital rubella syndrome), invasive Haemophilus influenzae type b (Hib), acute hepatitis B, hepatitis A, varicella, Streptococcus pneumoniae, and smallpox.