Publications by authors named "Roukayatou Omorou"
Background: Hemozoin is a byproduct of hemoglobin digestion crucial for parasite survival. It forms crystals that can be of interest as drug targets or biomarkers of malaria infection. However, hemozoin has long been considered as an amorphous crystal of simple morphology.
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- The review focuses on the challenges and methodologies for producing Plasmodium gametocytes in vitro, which is crucial for research in drug and vaccine development.
- A systematic analysis of 23 studies published since 2000 revealed that most in vitro research utilized environmental stressors to induce gametocyte formation, with mature gametocytemia reaching up to 4%.
- The findings emphasize the importance of understanding biological factors for effective gametocyte production and point out the necessity for protocols addressing other Plasmodium species beyond P. falciparum.
Background: Malaria still kills young children in rural endemic areas because early treatment is not available. Thus, the World Health Organization recommends the administration of artesunate suppositories as pre-referral treatment before transportation to the hospital in case of severe symptoms with an unavailable parenteral and oral treatment. However, negative cultural perception of the rectal route, and limited access to artesunate suppositories, could limit the use of artesunate suppositories.
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- The Indonesian government plans to move its capital from Jakarta to East Kalimantan on Borneo Island, which raises concerns about environmental issues like deforestation and biodiversity loss.
- There is a particular focus on the risk of increased cases of P. knowlesi malaria, as the Malaysian side of Borneo is a hotspot for this disease.
- Recent evaluations show that in the last four years, 545 P. knowlesi cases have been reported in Indonesia, primarily in Aceh and North Sumatra, indicating the need for better surveillance and prevention measures in the new capital area.
Artesunate is the current most potent antimalarial drug widely used for the treatment of malaria. Considering the emergence of artemisinin resistance, several situations may require a simple method for artesunate quantification. We thus developed a quantitative and a semi-quantitative biological method for the determination of artesunate in liquid samples.
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