Publications by authors named "Rouhollah Mehdinavaz Aghdam"

In advancing cardiac tissue engineering (CTE), the development of injectable hydrogels mirroring myocardial properties is pivotal. The designed hydrogels must not only support cardiac cell growth but also have to be conductive to properly promote the functionalities of cardiac cells. Here, a facile approach is developed to incorporate gold nanoparticles (AuNPs) into an injectable hydrogel composed of Alginate (Alg) and Gelatin (Gel).

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Effective treatment of infected bone defects resulting from multi-drug resistant bacteria (MDR) has emerged as a significant clinical challenge, highlighting the pressing demand for potent antibacterial bone graft substitutes. Mesoporous nanoparticles have been introduced as a promising class of biomaterials offering significant properties for treating bone infections. Herein, we synthesize antibacterial mesoporous hydroxyapatite substituted with zinc and gallium (Zn-Ga:mHA) nanoparticles using a facile sol-gel method.

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Mesoporous silica nanoparticles (MSNPs) coated by chitosan (CS) were shown to be a proper candidate as a carrier for drug delivery purposes. However, choosing the suitable drug-containing complexes to be applied on MSNPs-CS is of much greater importance to evaluate the possible candidate for an efficient combination of cell viability, drug release kinetics, and atherosclerosis prevention. In this regard, this study concentrates on the synthesis and assessment of coated MSNPs-CS designed for drug delivery purposes.

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Article Synopsis
  • Median sternotomy surgery is a common approach in cardiac surgery, and this study introduces a new bone adhesive inspired by natural adhesives found in mussels and sandcastle worms.
  • The developed adhesive incorporates a special nanocomposite that shows superior adhesive strength, antibacterial properties, and promotes quick blood coagulation, making it more effective than existing commercial adhesives.
  • This new adhesive has demonstrated significant bioactivity and ability to support bone healing in a rabbit model, suggesting it may address challenges faced in surgical procedures involving sternum repair.
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  • - This study explores the incorporation of antibacterial garlic extract into titanium oxide nanotubes (TNTs) on titanium implants to enhance antibacterial properties and cell viability.
  • - Researchers confirmed the nanotubes’ formation and analyzed the garlic extract for bioactive sulfur compounds using various spectroscopic techniques, finding that lower concentrations of garlic extract (0.1 g/mL) improved cell viability and inhibited bacterial growth.
  • - Higher concentrations (0.2 g/mL) of garlic extract negatively affected cell viability and revealed potential toxicity linked to diethyl phthalate, while the 0.1 g/mL concentration showed promising antibacterial effects without significant adverse impacts on cells.
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Surface modification of titanium and its alloys has been seriously considered by researchers to improve their biological behaviors, in the past few decades. In present research, hydroxyapatite (HA) based composite coatings with different concentrations of 0, 2, 4, and 6 wt% of silver (Ag) nanoparticles were electrophoretically deposited (EPD) on anodized and non-anodized Ti6Al4V, using a direct current at a voltage of 30 V for 10 min at room temperature. The specimens were then characterized by means of X-ray diffraction (XRD) analysis, Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) equipped with energy dispersive spectroscopy (EDS).

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In the present study, ZIF-8 metal-organic framework (MOF) modified with Tannic acid (TA@ZIF-8) was synthesized and impregnated in alginate-gelatin (Alg-Gel) hydrogel. The Alg-Gel scaffolds containing 0, 5, and 10 % of TA@ZIF-8 were fabricated through the 3D printing method specifically denoted as Alg-Gel 0 %, Alg-Gel 5 %, and Alg-Gel 10 %. XRD, FTIR, FESEM, and EDX physically and chemically characterized the synthesized ZIF-8 and TA@ZIF-8 MOFs.

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Mg-based biomaterials are commonly used as biodegradable orthopedic implants (e.g., bone regeneration applications).

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Background: cell tracking after transplantation in regenerative medicine remains an unmet challenge and limits current understanding of the wound healing mechanism through cell-based therapies. This study investigated tracking of human Wharton's jelly stem cells (hWJSCs) seeded onto an acellular dermal matrix (ADM) and labeled with superparamagnetic iron oxide nanoparticles (SPIONs) by magnetic resonance imaging (MRI) in burn injury.

Method: The hWJSCs were characterized and assessed for growth kinetics.

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Recently, postoperative bone infections have been one of the most crucial challenges for surgeons. This study aims to synergistically promote antibacterial and osteoconductive properties of hydroxyapatite (HAp) nanoparticles through binary doping of Zn and Ga ions (Zn-Ga:HAp). Zn-Ga:HAp nanopowders with spherical morphology and homogeneous size are synthesized using a simple sol-gel method.

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Article Synopsis
  • A nanocomposite coating made of hydroxyapatite and carbon nanotubes (HA-CNTs) was applied to anodized titanium alloy using an electrophoretic method to examine its stability in simulated body fluid.
  • The coating was analyzed using scanning electron microscopy (SEM) for its microstructure and X-ray diffraction (XRD) for its crystallographic properties, revealing that adding up to 5% carbon nanotubes improved various coating properties.
  • Results showed enhanced corrosion resistance, better coating adhesion, reduced cracks, and increased cell viability with a maximum improvement at 3% concentration of carbon nanotubes.
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Due to the presence of electric fields and piezoelectricity in various living tissues, piezoelectric materials have been incorporated into biomedical applications especially for tissue regeneration. The piezoelectric scaffolds can perfectly mimic the environment of natural tissues. The ability of scaffolds which have been made from piezoelectric materials in promoting cell proliferation and regeneration of damaged tissues has encouraged researchers in biomedical areas to work on various piezoelectric materials for fabricating tissue engineering scaffolds.

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By introducing biomaterials and stem cells into Parkinson's disease (PD), therapeutic approaches have led to promising results due to facilitating brain targeting and blood-brain barrier permeation of the drugs and genes. Here, after reviewing the most recent drug- and gene-delivery vehicles including liposomes, exosomes, natural/synthetic polymeric particles/fibers, metallic/ceramic nanoparticles and microbubbles, used for Parkinson's disease treatment, the effect of stem cells as a reservoir of neurotrophic factors and exosomes is provided.

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Cardiovascular disease is one of the most common causes of death worldwide. Mesenchymal stem cells (MSCs) are one of the most common sources in cell-based therapies in heart regeneration. There are several methods to differentiate MSCs into cardiac-like cells, such as gene induction.

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Myocardial infarction (MI), triggered by blockage of a coronary artery, remains the most common cause of death worldwide. After MI, the capability of providing sufficient blood and oxygen significantly decreases in the heart. This event leads to depletion of oxygen from cardiac tissue and consequently leads to massive cardiac cell death due to hypoxemia.

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After myocardial infarction caused by a heart attack, endothelial cells need to be preserved in order to regenerate new capillaries. Moreover, sufficient mechanical support is necessary for the infarcted myocardium to pump the blood. Herein, we designed a novel substrate containing polyurethane (PU) nanofibrous layers and recombinant human erythropoietin (rhEPO)-loaded microparticles for both controlled releases of rhEPO and mechanical support of myocardium.

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Since the emergence of the novel coronavirus, named COVID-19, researchers are looking for a treatment to stop the devastating pandemic. During these efforts, mesenchymal stem cells (MSCs), the potential next generation of therapeutic methods with wide application for diseases, have successfully controlled cytokine storm following the virus infection. However, the use of MSCs has been limited due to the ethical issues, immunogenicity, and genetic modifications.

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As a novel cardiac myosin activator, Omecamtive Mecarbil (OM) has shown promising results in the management of systolic heart failure in clinical examinations. However, the need for repeated administration along with dose-dependent side effects made its use elusive as a standard treatment for heart failure (HF). We hypothesized that improved cardiac function in systolic HF models would be achieved in lower doses by targeted delivery of OM to the heart.

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Background: Various methods were introduced to overcome the autograft shortage in burn wound care, including cell transplantation and tissue engineering.

Aims: To evaluate the healing effect of allogenic human Wharton's jelly stem cells (hWJSCs) seeded onto acellular dermal matrix (ADM) in rat burn injuries.

Patients And Methods: Human Wharton's jelly stem cells provided from umbilical cord tissue were characterized before transplantation, and the growth kinetic was determined.

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Recently, Injectable Conducting Hydrogel (ICH) systems have gained much attention for tissue engineering and regenerative medicine. These systems can promote the regeneration of tissues responding to electrical responses. In this study, a novel ICH system was introduced.

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The formation of ZrB2 nanoparticles through reaction of Zr(n-PrO)4 with H3BO3 and carbon has been studied with different ligands by carbothermal reduction at 1500 degrees C. In the first step, by introducing N, N'-bis (salicylidene)-1,3-diaminopropane (H2salpn) or salicylaldehyde (Hsal) species into reaction mixture, the reaction of the zirconium alkoxide using citric acid and boric acid yielded the zirconium diboride (ZrB2) sol-gel precursors. In the second step, the mixture was heated by introducing the reactant compact into an argon furnace held at 1500 degrees C for 2 h to obtain the final pure phase ZrB2 nanocrystallites with a diameter of about 50 nm.

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The presence of pharmaceutical compounds in water and soil has become an environmental concern. The aim of this study was to evaluate the performance of TiO2 nanofiber in the oxidation of the antibiotic tetracycline. TiO2 nanofiber was fabricated by electro-spinning method, and then was calcined at 560°C for 2 h.

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