Standing on a Double-Seesaw Device is an Easy Way to Modify the Coordination Between the Two Feet for Controlling Upright Stance: Assessment Through Weight-Bearing Asymmetry.

Healthy young subjects were instructed to modify their weight-bearing asymmetry when standing on a double-seesaw device. The results indicated decreased and unchanged amplitudes in the center-of-pressure movements under the unloaded and loaded legs, respectively. In addition, a concomitant increased contribution of the more loaded leg and a decreased contribution of the pressure distribution mechanism along the mediolateral axis were observed in the production of the resultant center of pressure, its amplitude remaining constant.

Upright stance on a single vs double seesaw: are automatic and voluntary components similarly involved in balance control?

The relevance of seesaw devices in postural evaluation and training is gathering growing evidence due to its sensory-motor specificity. Nonetheless, the physiological specificities resulting from the dissociation or not of the seesaws (single vs double) still need to be investigated, in particular by assessing the respective contribution of automatic and voluntary components in the postural control. A protocol based on attention disturbance through a dual-task paradigm was set to establish this contribution.

Undisturbed stance on a double seesaw: Interaction between asymmetries of the center-of-pressure patterns under each foot and weight-bearing.

Both center-of-pressure (CP) displacements under each foot and relative body-weight distribution intervene in the production of resultant CP movements. To better understand their respective involvement, a protocol was set up for young healthy individuals consisting in standing on a double seesaw, favoring pitch motions and laying on a dual-force platform. The postural control effects induced by two types of asymmetry, weight-bearing and the CP movement patterns, were investigated.

Upright standing after stroke: How loading-unloading mechanism participates to the postural stabilization.

Postural strategies employed by hemiparetic stroke patients need to be better understood to guide rehabilitation. Of the two complementary mechanisms used to stabilize the standing posture, loading-unloading (LU) and pressure distribution (PD), it is hypothesized that the former would be predominantly used. To this aim, posturographic assessments, through a dual force-platform, were performed in 30 Hemiparetics tested 3 months after a unilateral stroke, and 30 matched healthy Controls.

Biomechanical Study of Tandem Stance in Healthy Young Adults: Effects of Weight-Bearing and Limb Dominance.

Postural strategies of healthy young adults to control tandem stance were investigated through the calculation of the relative contribution of the two loading-unloading (LU) and pressure-distribution (PD) mechanisms and the two legs for controlling the resultant center-of-pressure (CP) displacements. Weight-bearing asymmetry and limb dominance were also studied. For antero-posterior and medio-lateral CP displacements, LU and PD mechanisms mainly contribute, respectively.

Postural control in healthy young adults using a double seesaw device.

Postural control on single and double seesaws was investigated in young healthy adults required to stand as still as possible on two side-by-side seesaws favoring pitch motion and lying on two separate force platforms. The device offers the possibility to get associated or dissociated seesaws and, if dissociated, to induce asymmetric patterns for the centers-of-pressure (CP) under both left and right feet by using different radii for the two seesaws. Substituting a parallelepiped volume to one seesaw offering a firm contact to one foot is also possible.

Attentional cost in additional visual feedback protocols in healthy young subjects.

Additional visual feedback (VFB) is a technique allowing improved postural stability in young healthy individuals despite an increased muscular activity, the two trends being assessed through center-of-gravity (CG) and differences between CG and center-of-pressure (CP) movements (CP-CG), respectively. These two opposing effects are likely explained by the respective contribution of automatic and voluntary controls and in turn the neural circuits involved. To specify these specific contributions, a dual-task protocol was set up, consisting in adding to VFB a navigation task performed at the maximum cognitive capacities of the subjects who were evaluated beforehand.

Overweight is associated to a better prognosis in metastatic colorectal cancer: A pooled analysis of FFCD trials.

Background: Previous studies showed that high and low body mass index (BMI) was associated with worse prognosis in early-stage colorectal cancer (CRC), and low BMI was associated with worse prognosis in metastatic CRC (mCRC). We aimed to assess efficacy outcomes according to BMI.

Patients And Methods: A pooled analysis of individual data from 2085 patients enrolled in eight FFCD first-line mCRC trials from 1991 to 2013 was performed.

Phase III randomized trial comparing 5-fluorouracil and oxaliplatin with or without docetaxel in first-line advanced gastric cancer chemotherapy (GASTFOX study).

Introduction: In advanced gastric cancer, doublet regimen including platinum salts and fluoropyrimidine is considered as a standard first-line treatment. The addition of docetaxel (75 mg/m q3w) to cisplatin (75 mg/m q3w) and 5-fluorouracil has been shown to improve efficacy. However, this regimen (DCF) was associated with frequent severe toxicities (including more complicated neutropenia), limiting its use in clinical practice.

Hepatic arterial infusion in the management of colorectal cancer liver metastasis: Current and future perspectives.

The technique of hepatic arterial infusion (HAI) for the treatment of liver metastases from colorectal cancer has been developed over more than 30 years. Although the indications and protocols for this technique have evolved with time, HAI is not routinely performed in clinical practice. Studies have been heterogeneous, with different regimens of intra-arterial drugs, associated or not with systemic chemotherapy, and with unconvincing outcomes.

Improving Outcomes in Patients with CRC: The Role of Patient Reported Outcomes-An ESDO Report.

Colorectal cancer is one of the most commonly diagnosed cancers worldwide and nearly half of patients will develop metastatic disease at some point during the course of their disease. The goal of anticancer therapy in this context is to extend survival, while trying to maximise the patient's health-related quality of life. To this end, we need to understand how to incorporate patient-reported outcomes into clinical trials and routine practice to accurately assess if treatment strategies are providing clinical benefit for the patient.

Influence of slope steepness, foot position and turn phase on plantar pressure distribution during giant slalom alpine ski racing.

The purpose of this study was to investigate the evolution of ground reaction force during alpine skiing turns. Specifically, this study investigated how turn phases and slope steepness affected the whole foot normal GRF pattern while performing giant slalom turns in a race-like setting. Moreover, the outside foot was divided into different plantar regions to see whether those parameters affected the plantar pressure distribution.

A need to simplify informed consent documents in cancer clinical trials. A position paper of the ARCAD Group.

Background: In respect of the principle of autonomy and the right of self-determination, obtaining an informed consent of potential participants before their inclusion in a study is a fundamental ethical obligation. The variations in national laws, regulations, and cultures contribute to complex informed consent documents for patients participating in clinical trials. Currently, only few ethics committees seem willing to address the complexity and the length of these documents and to request investigators and sponsors to revise them in a way to make them understandable for potential participants.

Hepatic Arterial Infusion Chemotherapy for Unresectable Liver Metastases of Colorectal Cancer: A Multicenter Retrospective Study.

Introduction: Hepatic arterial infusion chemotherapy (HAIC) is a treatment used for liver metastases (LM) of colorectal cancer (CRC). Because of its technical conditions, it has been used in only a few experienced centers in France. Our aim was to evaluate its feasibility, efficacy and tolerance in 4 centers.

Interaction between postural asymmetry and visual feedback effects in undisturbed upright stance control in healthy adults.

Objectives: The technique of additional visual feedback has been shown to significantly decrease the center of pressure (CP) displacements of a standing subject. Body-weight asymmetry is known to increase postural instability due to difficulties in coordinating the reaction forces exerted under each foot and is often a cardinal feature of various neurological and traumatic diseases. To examine the possible interactions between additional visual feedback and body-weight asymmetry effects, healthy adults were recruited in a protocol with and without additional visual feedback, with different levels of body-weight asymmetry.

Chemoembolization of Neuroendocrine Liver Metastases Using Streptozocin and Tris-acryl Microspheres: Embozar (EMBOsphere + ZAnosaR) Study.

Purpose: The purpose of this prospective observational study was to evaluate the efficacy and tolerability of transarterial chemoembolization (TACE) for neuroendocrine liver metastases using a combination of streptozocin, Lipiodol, and tris-acryl microspheres.

Patients And Methods: A total of 16 men and 9 women aged 59.6 ± 11.

The multidisciplinary management of gastro-oesophageal junction tumours: European Society of Digestive Oncology (ESDO): Expert discussion and report from the 16th ESMO World Congress on Gastrointestinal Cancer, Barcelona.

Background And Scope: The management of GOJ cancers remains controversial and may vary between countries. Evidence-based attitudes and guidelines are not easy to elaborate since most of the trials and studies reported mixed cases of oesophageal (both adenocarcinoma and squamous cell tumours), GOJ and gastric cancers. The aim of this expert discussion and position paper is to elaborate practical recommendations that integrate evidence-reported literature and experience-based attitude covering all clinical aspects of GOJ cancer across different specialities and countries in Europe.

Early tumour response as a survival predictor in previously- treated patients receiving triplet hepatic artery infusion and intravenous cetuximab for unresectable liver metastases from wild-type KRAS colorectal cancer.

Background: Early tumour shrinkage has been associated with improved survival in patients receiving cetuximab-based systemic chemotherapy for liver metastases from colorectal cancer (LM-CRC). We tested this hypothesis for previously treated LM-CRC patients receiving cetuximab (500 mg/m) and triplet hepatic artery infusion (HAI) within European trial OPTILIV.

Methods: Irinotecan (180 mg/m), 5-fluorouracil (2800 mg/m) and oxaliplatin (85 mg/m) were given as chronomodulated or conventional delivery.

Imaging in Colorectal Cancer: Progress and Challenges for the Clinicians.

The use of imaging in colorectal cancer (CRC) has significantly evolved over the last twenty years, establishing important roles in surveillance, diagnosis, staging, treatment selection and follow up. The range of modalities has broadened with the development of novel tracer and contrast agents, and the fusion of technologies such as positron emission tomography (PET) and computed tomography (CT). Traditionally, the most widely used modality for assessing treatment response in metastasised colon and rectal tumours is CT, combined with use of the RECIST guidelines.

Emergency therapy for liver metastases from advanced VIPoma: surgery or transarterial chemoembolization?

VIPoma is a rare neuroendocrine tumor (NET) with a high potential to develop hepatic metastases and poor prognosis. The primitive tumor is nonsymptomatic and usually localized within the pancreas. Liver metastasis drives the prognosis and induces profuse watery diarrhea or renal failure.

How does wearing a lumbar orthosis interfere with gait initiation?

The interaction between medical devices and the human body must be evaluated in standardised laboratory tests. Since wearing a lumbar orthosis is assumed to reduce lower back mobility and reinforce trunk movement control through imposed lordosis, this device is expected to affect gait initiation which requires trunk and pelvic rotations. Thirteen healthy subjects were asked to initiate gait without orthosis (control) and orthosis with or without lordosis constraints.

Treatment sequence of synchronously (liver) metastasized colon cancer.

No standards for staging, systemic therapy or the timing of an operation are defined for patients newly diagnosed with synchronous metastases and a primary in the colon. An expert group of radiologists, medical, radiation and surgical oncologists therefore came together to discuss staging and treatment sequence for these patients and came up with a recommendation based on current evidence of potential therapeutic options. The discussion was organized to debate recommendations centred on 5 topics and therefore the position paper is built upon these titles and their subtitles.

How providing more or less time to solve a cognitive task interferes with upright stance control; a posturographic analysis on healthy young adults.

Contrasted postural effects have been reported in dual-task protocols associating balance control and cognitive task that could be explained by the nature and the relative difficulty of the cognitive task and the biomechanical significance of the force platform data. To better assess their respective role, eleven healthy young adults were required to stand upright quietly on a force platform while concomitantly solving mental-calculation or mental-navigation cognitive tasks. Various levels of difficulty were applied by adjusting the velocity rate at which the instructions were provided to the subject according to his/her maximal capacities measured beforehand.

Efficacy of modern chemotherapy and prognostic factors in patients with ovarian metastases from gastric cancer: A retrospective AGEO multicentre study.

Background: Ovarian metastases from gastrointestinal tumours frequently lead to locoregional complications and undermine quality of life. The chemosensitivity of ovarian metastases from gastric cancer is unknown.

Aim: To evaluate the efficacy of modern chemotherapy regimens in first-line treatment for patients with ovarian metastases from gastric cancer.