Publications by authors named "Rougier M"
Article Synopsis
- The study investigated the link between air pollution and cataract surgery incidence in older adults in Bordeaux, France.
- Researchers followed 829 participants aged 65 and older from 1999-2017, monitoring their cataract surgeries and estimating their long-term air pollution exposure.
- Results showed that long-term exposure to nitrogen dioxide (NO) at levels ≥40 μg/m was significantly associated with increased incidence of cataract surgery, suggesting that meeting air quality standards could benefit public health.
Article Synopsis
- The study aimed to compare the effectiveness of subconjunctival triamcinolone acetonide injections with intravitreal dexamethasone implants in reducing central macular thickness in patients with uveitic and postoperative macular edema.
- An open-label, multicenter trial involved 106 adults who were randomly assigned to receive either treatment; the main measure was the change in central macular thickness after 2 months.
- Results indicated that triamcinolone is likely as effective as dexamethasone, particularly for postoperative edema, with no significant differences in side effects, but conclusive non-inferiority was not established at the 2-month mark.
Objective: To investigate the associations between circulating vitamins A, D, E, B6, B9, B12 and longitudinal changes in retinal nerve fiber layer (RNFL) thickness.
Methods: The Alienor study, a prospective population-based cohort (Bordeaux, France), includes 963 individuals aged 73 years or older at baseline. The present study included 646 participants with complete RNFL measurement and vitamins.
Purpose: To evaluate the safety and efficacy of the fluocinolone acetonide implant (FAi, Iluvien Horus pharma, Nice, France) in non-infectious uveitic macular edema (UME) and to approach the predictive factors of treatment response.
Methods: This retrospective, multicenter real-life study included patients with chronic non-infectious UME who received intravitreal FAi after at least two dexamethasone implants (DEXi).
Results: Twenty-six eyes from 22 patients (73.
Article Synopsis
- The study aimed to examine how blood pressure (BP) changes throughout the day and night in patients with non-arteritic anterior ischemic optic neuropathy (NAION).
- 65 patients with acute NAION underwent 24-hour ambulatory blood pressure monitoring (ABPM), using different definitions for nighttime periods to classify their BP patterns.
- Results showed a high prevalence of extreme dippers (23%) during the strictest nighttime definition, and many patients (39%) without known hypertension were found to have elevated BP, indicating that ABPM is important for assessing BP in NAION patients.
Objective: This study aimed to develop a deep learning (DL) model, named 'DeepAlienorNet', to automatically extract clinical signs of age-related macular degeneration (AMD) from colour fundus photography (CFP).
Methods And Analysis: The ALIENOR Study is a cohort of French individuals 77 years of age or older. A multi-label DL model was developed to grade the presence of 7 clinical signs: large soft drusen (>125 μm), intermediate soft (63-125 μm), large area of soft drusen (total area >500 μm), presence of central soft drusen (large or intermediate), hyperpigmentation, hypopigmentation, and advanced AMD (defined as neovascular or atrophic AMD).
Purpose: To test the hypothesis that central drusen location is strongly linked with known Age-related Macular Degeneration (AMD) risk factors and risk of incident late AMD.
Methods: The Alienor study is a prospective population-based cohort study of residents of Bordeaux, France, followed from 2009 to 2017. On retinal photographs, we defined central drusen as at least one soft drusen (>63 μm) within 500 μm from fovea and pericentral drusen as at least one drusen 500-3000 μm from fovea, in the absence of any central drusen.
Article Synopsis
- The study focuses on albinism, a genetic condition where melanin production is affected, highlighting the variability in its forms and their impact on ocular health.
- A retrospective analysis was performed on 127 patients with oculocutaneous albinism from a specific hospital in France, assessing their genetic data and visual acuity.
- The findings revealed no significant differences in visual acuity across the main forms of albinism, but significant differences in ametropia were observed, along with a high prevalence of grade 4 foveal hypoplasia among patients, independent of the gene involved.
Chronic exposure to air pollution may have adverse effects on neurodegenerative diseases. Glaucoma, the second leading cause of blindness worldwide, is a neurodegenerative disease of the optic nerve, characterized by progressive thinning of the retinal nerve fiber layer (RNFL). We investigated the relationship of air pollution exposure with longitudinal changes of RNFL thickness in the Alienor study, a population-based cohort of residents of Bordeaux, France, aged 75 years or more.
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- The study focuses on verifying the placement of fluocinolone (FAc) corticosteroid implants in the vitreous cavity after injection, using various clinical and imaging methods.
- It involved 12 patients at Bordeaux University Hospital, where different techniques like indirect biomicroscopy and ultrasonography were employed to check for the implant’s presence immediately and one week post-injection.
- Results showed that UBM ultrasonography was the most effective method, detecting 75% of implants, highlighting the necessity of accurate assessment methods for implant positioning.
Background: Nonarteritic anterior ischemic optic neuropathy (NAAION) is a major cause of blindness in individuals over 50 years of age, with no available effective treatment. The oral dual endothelin receptor antagonist, bosentan, increases retinal optic nerve head blood flow in healthy humans and glaucoma patients. The objective of this trial is to assess the efficacy of bosentan administered at the acute stage in improving outcomes in NAAION patients.
View Article and Find Full Text PDFThere is no consensus regarding the classification of optic neuritis, and precise diagnostic criteria are not available. This reality means that the diagnosis of disorders that have optic neuritis as the first manifestation can be challenging. Accurate diagnosis of optic neuritis at presentation can facilitate the timely treatment of individuals with multiple sclerosis, neuromyelitis optica spectrum disorder, or myelin oligodendrocyte glycoprotein antibody-associated disease.
View Article and Find Full Text PDFB vitamins may protect against age-related macular degeneration (AMD). We evaluated the associations of dietary intake and serum vitamins with the incidence of advanced AMD in the Alienor study. The Alienor study is a prospective population-based cohort of 963 residents of Bordeaux, France, who were 73 years or older at baseline (2006-2008).
View Article and Find Full Text PDFPurpose: The aim of this study was to analyze retinal microvasculature in obese subjects as compared to a normal-weight population.
Methods: In this case-control observational study, swept-source optical coherence tomography angiography (SS-OCTA) and adaptive optics (AO) were performed in eyes of nondiabetic, nonhypertensive, obese patients and in healthy controls. AO was used to calculate the wall-to-lumen ratio (WLR).
Purpose: To report a case series of 3 patients with choroidal granulomas due to infection in order to raise awareness about this etiology in the differential diagnosis of choroidal granulomas.
Methods, Patients: A retrospective case series of patients with choroidal granulomas due to infection who consulted between 2018 and 2020. Data were collected from the medical records (demographics, visual acuity (VA), laboratory tests, treatment, imaging).
Objective: To evaluate diagnostic and therapeutic practices and then establish a consensus on the management of ocular toxoplasmosis in France through a Delphi study.
Materials And Methods: Twenty-three French experts in ocular toxoplasmosis were invited to respond to a modified Delphi study conducted online, in the form of two questionnaires, in an attempt to establish a consensus on the diagnosis and management of this pathology. The threshold for identical responses to reach consensus was set at 70 %.
Background: To quantitatively compare the peripapillary microvascular network between patients with papilledema and healthy subjects using swept source optical coherence tomography angiography.
Methods: In this retrospective observational study, patients with papilledema secondary to idiopathic intracranial hypertension and healthy controls were imaged with swept source optical coherence tomography angiography (PLEX Elite 9000; Carl Zeiss Meditec, Dublin, CA) using a 6 × 6 mm scan pattern centered on the optic disc. The capillary perfusion density (CPD) and capillary flux index (CFI) of the radial peripapillary capillaries in the retinal nerve fiber layer (RNFL) were calculated using Zeiss algorithm.
Introduction: Toxoplasma retinochoroiditis (TRC) is the main cause of posterior uveitis in immunocompetent patients. Several studies have shown safety and efficacy of treatment with intravitreal clindamycin injection in patients with contraindications, inadequate response or side effects with classic oral therapy. The goal of this study is to describe anatomic and functional results of local treatment with intravitreal clindamycin injection.
View Article and Find Full Text PDFLutein and zeaxanthin may lower the risk of age-related macular degeneration (AMD). We evaluated the associations of plasma lutein and zeaxanthin with the incidence of advanced AMD in the Alienor study (Antioxydants Lipides Essentiels Nutrition et Maladies Oculaires). Alienor study is a prospective population-based cohort of 963 residents of Bordeaux, France, who were 73 years or older at baseline (2006-2008).
View Article and Find Full Text PDFThe literature on the approach/avoidance training (AAT) effect has focused on its evaluative consequences (with approached stimuli evaluated as more positive than avoided ones). Building on a grounded cognition framework, we investigated AAT effects on the visual representation of stimuli (here, neutral faces). We formulated specific predictions regarding the facial features that should be the most biased and the conditions under which the effect should be the strongest.
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