Publications by authors named "Roughton S"

Dysregulated host responses to infection can lead to organ dysfunction and sepsis, causing millions of global deaths each year. To alleviate this burden, improved prognostication and biomarkers of response are urgently needed. We investigated the use of whole-blood transcriptomics for stratification of patients with severe infection by integrating data from 3149 samples from patients with sepsis due to community-acquired pneumonia or fecal peritonitis admitted to intensive care and healthy individuals into a gene expression reference map.

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From December 2014 to April 2015, seven cases of malaria were seen in 1530 military personnel deployed to Sierra Leone on Operation GRITROCK in response to the West African Ebola outbreak, despite predeployment briefings, prescription of chemoprophylactic agents and bite prevention measures. The cases have prompted discussion regarding the efficacy of current measures and how to prevent future cases in deployed military personnel or more widely, those working in malaria-risk environments. All of the cases have made a full recovery and returned to work.

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Aim: This study identified characteristics and perceptions of nursing faculty that best predict their intentions to leave their faculty positions.

Background: The inadequate supply of nursing faculty is a situation that requires immediate intervention, yet evidence on factors associated with nurse faculty intent to leave their faculty positions is sparse.

Method: Survey data from 4,118 nurse faculty teaching in pre-licensure and graduate nursing education programs were analyzed.

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Plasmodium knowlesi is a zoonosis and is now recognised as the fifth commonly occurring form of human malaria. It is endemic in South East Asia, including some areas previously declared malaria free or at low risk for malaria. The epidemiology of the disease is very different to other forms of malaria which are determined by transmission by anthrophilic mosquitoes from human reservoirs.

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UK forces deployed to Afghanistan between March and November are prescribed anti-malarial chemoprophylaxis (AMC). In 2007 an audit showed poor pre-injury AMC compliance and a prescription rate of 50% amongst those casualties evacuated to Role 4. We re-audited the post-deployment AMC prescribing practice for casualties from Afghanistan for the 2008 and half of the 2009 malaria season.

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Introduction: Data on quality of life beyond 2 years after intensive care discharge are limited and we aimed to explore this area further. Our objective was to quantify quality of life and health utilities in the 5 years after intensive care discharge.

Methods: A prospective longitudinal cohort study in a University Hospital in the UK.

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Objectives: To test the hypothesis that nurse led follow-up programmes are effective and cost effective in improving quality of life after discharge from intensive care.

Design: A pragmatic, non-blinded, multicentre, randomised controlled trial.

Setting: Three UK hospitals (two teaching hospitals and one district general hospital).

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Compliance officers are in a unique position to provide guidance to physicians and will succeed in gaining physician support and buy-in when appropriate steps are taken to integrate physicians into the compliance program. First and foremost, the compliance officer's primary responsibility is to apprise physicians of the seriousness nature of current compliance issues. When physicians are provided with clear information through a variety of media, they will understand that compliance program goals and objectives will resolve compliance-related issues dilemmas.

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Apoptosis has been found to occur during regression of the corpus luteum (CL) in many species. The Fas (APO-1/CD95) receptor, a transmembrane protein that induces apoptosis in the cell when bound to Fas ligand (FasL), may be involved. This study established and quantitated the presence and regulation of Fas receptor and FasL in the rat CL during pregnancy and postpartum.

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