Publications by authors named "Rouel Lanche"
Article Synopsis
- COVID-19 and influenza are respiratory illnesses caused by different viruses but share some symptoms and clinical risk factors, yet their genetic connections remain poorly understood.
- A study involving over 18,000 influenza cases and nearly 276,000 control subjects found no common genetic risk factors between COVID-19 and influenza, revealing specific gene variants linked only to influenza.
- The research highlights the potential for targeting cell surface receptors involved in viral entry, showing that manipulating specific genes could lead to treatments that prevent both COVID-19 and influenza infections.
Article Synopsis
- The Mexico City Prospective Study is a large-scale research initiative involving over 150,000 adults from urban areas in Mexico City, aimed at understanding genetic diversity and ancestry.
- The study reveals a mix of Indigenous American, European, and African ancestries among participants, highlighting significant genetic differences and a unique genetic landscape within the Indigenous Mexican population.
- Researchers created a valuable reference panel for genetic research, improving the accuracy of studying genetic variants in populations with high Indigenous ancestry, and providing essential resources for future genetic studies in both Mexico and the US.
Article Synopsis
- A genome-wide association study identified a genetic variant (rs190509934) that reduces ACE2 expression by 37% and lowers the risk of SARS-CoV-2 infection by 40%.
- The study confirms six previously known genetic risk variants, with four linked to worse outcomes in COVID-19 infected individuals.
- A risk score based on common variants was developed, which improves prediction of severe disease beyond just demographic and clinical factors.
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), a respiratory illness that can result in hospitalization or death. We used exome sequence data to investigate associations between rare genetic variants and seven COVID-19 outcomes in 586,157 individuals, including 20,952 with COVID-19. After accounting for multiple testing, we did not identify any clear associations with rare variants either exome wide or when specifically focusing on (1) 13 interferon pathway genes in which rare deleterious variants have been reported in individuals with severe COVID-19, (2) 281 genes located in susceptibility loci identified by the COVID-19 Host Genetics Initiative, or (3) 32 additional genes of immunologic relevance and/or therapeutic potential.
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