Genetic algorithm with cross-validation-based epidemic model and application to the early diffusion of COVID-19 in Algeria.

A dynamical epidemic model optimized using a genetic algorithm and a cross-validation method to overcome the overfitting problem is proposed. The cross-validation procedure is applied so that available data are split into a training subset used to fit the algorithm's parameters, and a smaller subset used for validation. This process is tested on Italy, Spain, Germany, and South Korea cases before being applied to Algeria.

Open-label phase II to evaluate the efficacy of NEoadjuvant dose-dense MVAC In cOmbination with durvalumab and tremelimumab in muscle-invasive urothelial carcinoma: NEMIO.

Background: Neoadjuvant cisplatin-based chemotherapy (NAC) is the standard of care in localized muscle-invasive bladder cancer (MIBC). However, 60-70% of patients have residual tumor after NAC. Based on the overall response rate observed in the metastatic setting, ddMVAC is the most commonly used NAC regimen in Europe.

Review shows that using surfactant a number of times or as a vehicle for budesonide may reduce the risk of bronchopulmonary dysplasia.

Aim: Bronchopulmonary dysplasia (BPD) remains the most common respiratory morbidity in immature infants. This review describes the diagnosis of BPD has evolved and summarises the therapeutic approaches that have made it possible to limit the incidence of BPD.

Method: We reviewed the literature from the first definition of BPD by Northway in 1967 to the surfactant treatment policies that are currently in use, drawing on more than 50 papers up to 2017.

The effect of nefopam on lactation after caesarean section: a single-blind randomised trial.

Background: Nefopam is a centrally acting analgesic which has a theoretical risk of stopping lactation due to its anticholinergic and dopaminergic effects. The aim of this study was to evaluate the effect of nefopam on lactation and to investigate potential adverse effects on newborns.

Methods: Seventy-two women, scheduled to undergo a caesarean delivery under spinal anaesthesia and wanting to breastfeed, were randomised to one of two groups: nefopam (20mg, six hourly) or paracetamol (1g, six hourly).

[Childhood's ophthalmologic involvement in Sturge-Weber-Krabbe syndrome].

Ophthalmologic involvement in Sturge-Weber-Krabbe syndrome (SWKS) is present in 30-70% of cases and needs to be reviewed because of its impact on visual development. We report a case of a newborn for whom SSWK with ophthalmologic involvement was suspected. She had a right segmental plane angioma associated with right congenital glaucoma and suspected right pial angioma.

Late Surfactant Administration in Very Preterm Neonates With Prolonged Respiratory Distress and Pulmonary Outcome at 1 Year of Age: A Randomized Clinical Trial.

Importance: Although immature neonate survival has improved, there is an increased risk of developing bronchopulmonary dysplasia, leading to significant respiratory morbidity. Measures to reduce bronchopulmonary dysplasia are not always effective or have important adverse effects.

Objective: To evaluate the effect of late surfactant administration in infants with prolonged respiratory distress on ventilation duration, respiratory outcome at 36 weeks' postmenstrual age, and at 1 year postnatal age.

Coherence effects in scattering order expansion of light by atomic clouds.

We interpret cooperative scattering by a collection of cold atoms as a multiple-scattering process. Starting from microscopic equations describing the response of N atoms to a probe light beam, we represent the total scattered field as an infinite series of multiple-scattering events. As an application of the method, we obtain analytical expressions of the coherent intensity in the double-scattering approximation for Gaussian density profiles.

Echocardiography as a guide for patent ductus arteriosus ibuprofen treatment and efficacy prediction.

Objective: To evaluate echocardiography criteria in predicting the response to ibuprofen treatment.

Design: A prospective cohort study of preterm infants untreated or treated with ibuprofen for patent ductus arteriosus.

Setting: Three academic neonatal intensive care units.

[Secondary right-sided diaphragmatic hernia following neonatal group B Streptococcal septicaemia in a preterm infant].

We report on a case of a secondary right-sided diaphragmatic hernia following group B streptococcal (GBS) septicaemia in a very low birth weight infant born at 30 weeks. After initial improvement, the diagnosis of a secondary right-sided diaphragmatic hernia was suspected with the persistent radiological pulmonary right-sided image on the chest x-ray and the clinical degradation. The diagnosis was confirmed by ultrasonography on day 43.

[Thrombotic thrombocytopenic purpura in a newborn].

A newborn presented with haemolytic anemia, thrombocytopenia, hyperbilirubinemia and renal failure as early as the first hours of life. An early plasmatherapy was undertaken, followed by good outcome. The specific von Willebrand factor-cleaving protease (ADAMTS 13) was found at less than 5%.

[Neonatal renal vein thrombosis in a heterozygous carrier of both factor V Leiden and prothrombin mutations].

Unlabelled: We report a case of renal vein thrombosis, treated with heparin and thrombolytic therapy, in a patient who was heterozygous for both factor V Leiden and prothrombin mutations.

Case Report: A full-term infant was treated with heparin and fibrinolytics at the fourth day of life because of renal vein thrombosis, inferior vena cava thrombosis and adrenal hemorrhage. After four days of treatment, the repermeabilization was complete but a renal atrophy developed.