Publications by authors named "Roua Abulkassim"
Article Synopsis
- Liver cancer is the sixth most common cancer and the third leading cause of cancer-related deaths, with many exploring natural alternatives to traditional treatments like chemotherapy and surgery.
- Curcumin (CUR) shows promise with its antiinflammatory, antioxidant, and antitumor properties, influencing various cancer-related signaling pathways to help combat tumor growth and spread.
- Due to challenges like poor absorption and rapid metabolism, CUR's clinical use is limited, but advancements in nanotechnology enable the creation of CUR nanoformulations that improve delivery, reduce side effects, and enhance treatment effectiveness specifically for liver cancer.
Article Synopsis
- Research shows miRNA-128 (miR-128) plays a crucial role in the initiation and development of various cancers, impacting immune responses.
- There is potential for miR-128 to be used as a biomarker and a focus for new anticancer treatments due to its abnormal expression in tumors.
- The review explores miR-128's role in multiple cancers and discusses its influence on resistance to treatments and immunotherapy through exosomes.
Rationale: Major depressive disorder (MDD) is a leading cause of disability worldwide but currently prescribed treatments do not adequately ameliorate the disorder in a significant portion of patients. Hence, a better appreciation of its aetiology may lead to the development of novel therapies.
Objectives: In the present study, we have built on our previous findings indicating a role for protease-activated receptor-2 (PAR2) in sickness behaviour to determine whether the PAR2 activator, AC264613, induces behavioural changes similar to those observed in depression-like behaviour.
Proteinase-activated receptor-2 (PAR2) is widely expressed in the CNS but whether it plays a key role in inflammation-related behavioural changes remains unknown. Hence, in the present study we have examined whether PAR2 contributes to behaviour associated with systemic inflammation using PAR2 transgenic mice. The onset of sickness behaviour was delayed and the recovery accelerated in PAR2(-/-) mice in the LPS-induced model of sickness behaviour.
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