Temperature and volumetric effects on structural and dielectric properties of hybrid perovskites.

Three-dimensional organic-inorganic perovskites are rapidly evolving materials with diverse applications. This study focuses on their two representatives - acetamidinium manganese(II) formate (AceMn) and formamidinium manganese(II) formate (FMDMn) - subjected to varying temperature and pressure. We show that AceMn undergoes atypical pressure-induced structural transformations at room temperature, increasing the symmetry from ambient-pressure P2/n phase II to the high-pressure Pbca phase III.

Mesenchymal Stem Cells and Purinergic Signaling in Autism Spectrum Disorder: Bridging the Gap between Cell-Based Strategies and Neuro-Immune Modulation.

The prevalence of autism spectrum disorder (ASD) is still increasing, which means that this neurodevelopmental lifelong pathology requires special scientific attention and efforts focused on developing novel therapeutic approaches. It has become increasingly evident that neuroinflammation and dysregulation of neuro-immune cross-talk are specific hallmarks of ASD, offering the possibility to treat these disorders by factors modulating neuro-immunological interactions. Mesenchymal stem cell-based therapy has already been postulated as one of the therapeutic approaches for ASD; however, less is known about the molecular mechanisms of stem cell influence.

Topical netarsudil for the treatment of primary corneal endothelial degeneration in dogs.

This study evaluated the tolerability and efficacy of the topical rho-kinase inhibitor netarsudil for canine primary corneal endothelial degeneration (PCED). Twenty-six eyes of 21 client-owned dogs with PCED were enrolled in a prospective, randomized, vehicle control clinical trial and received topical netarsudil 0.02% (Rhopressa®) or vehicle control twice daily (BID) for the first 4 months.

Solute - solvent repulsion effects on the absorption spectra of anthracene in n-hexane investigated under high pressure.

The band positions in the UV-VIS absorption spectra of compressed solution of anthracene in n-hexane significantly depend not only on the dispersive but also on the repulsive solute-solvent interactions, what has so far been omitted. Their strength is determined not only by the solvent polarity but also by Onsager cavity radius changing with pressure. The results obtained for anthracene show that repulsive interactions should be included in the interpretation of barochromic and solvatochromic results of aromatic compounds.

Low-density preference of the ambient and high-pressure polymorphs of DL-menthol.

Lower-density polymorphs of DL-menthol were nucleated and crystallized in their high-pressure stability regions. Up to 0.30 GPa, the triclinic DL-menthol polymorph α, which is stable at atmospheric pressure, is less dense than a new β polymorph, which becomes stable above 0.

Competition of interactions and a new high-temperature phase of selenourea.

The aggregation of molecules is usually associated with a specific type of interaction, which can be altered by thermodynamic conditions. Under normal conditions, the crystal structure of selenourea, SeC(NH), phase α is trigonal, space group P3, Z = 27. Its large number of independent molecules (Z' = 9) can be associated with the formation of an NH.

High-Pressure Crystallization and Thermodynamic Stability Study on the Resolution of High-Density Enantiomers from Low-Density Racemates.

High-pressure recrystallization could be the cheapest clean method of resolving enantiomers from the racemates defying Wallach's rule. We have investigated the effect of pressure on sodium tartrate monohydrate (NaTa·HO), a notorious exception from Wallach's rule: both racemic polymorphs α-dl-NaTa·HO and β-dl-NaTa·HO are less dense than the enantiomers. According to the mobile-equilibrium principle, such high-density enantiomorphs should spontaneously separate under high pressures.

Normal Corneal Thickness and Endothelial Cell Density in Rhesus Macaques (Macaca mulatta).

Purpose: To define the normal range of central corneal thickness (CCT) and corneal endothelial cell density (ECD) in rhesus macaques (Macaca mulatta) and the effects of age, body weight, sex, and intraocular pressure (IOP) on these parameters.

Methods: Ophthalmic examinations were performed on 144 rhesus macaques without anterior segment pathology. The CCT was measured via ultrasound pachymetry (USP) and specular microscopy, and the ECD was semiautomatically and manually counted using specular microscopy.

Exchanged Metal-Hydrogen Anagostic Bonds and Resonance of Dithiocarbamate and Thioureide Mesomers.

The pressure-induced transformation of plane-square complex nickel(II) bis(N,N-diethyldithiocarbamate) between its soft dithiocarbamate (form I) and thioureide (form II) mesomeres is coupled to the interchange of anagostic Ni⋅⋅⋅H-C interactions from methylene to the methyl group, respectively. At 1.23 GPa, the clearly visible giant anomalous compressibility of the crystal reveals a potential-energy difference of 5.

Targeting ON-bipolar cells by AAV gene therapy stably reverses -congenital stationary night blindness.

SignificanceCanine models of inherited retinal diseases have helped advance adeno-associated virus (AAV)-based gene therapies targeting specific cells in the outer retina for treating blinding diseases in patients. However, therapeutic targeting of diseases such as congenital stationary night blindness (CSNB) that exhibit defects in ON-bipolar cells (ON-BCs) of the midretina remains underdeveloped. Using a leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 () mutant canine model of CSNB exhibiting ON-BC dysfunction, we tested the ability of cell-specific AAV capsids and promotors to specifically target ON-BCs for gene delivery.

High-pressure and environment effects in selenourea and its labile crystal field around molecules.

Ambient-pressure trigonal phase α of selenourea SeC(NH) is noncentrosymmetric, with high Z' = 9. Under high pressure it undergoes several intriguing transformations, depending on the pressure-transmitting medium and the compression or recrystallization process. In glycerine or oil, α-SeC(NH) transforms into phase β at 0.

High-pressure preference for reduced water content in porous zinc aspartate hydrates.

The zinc aspartate (ZnAsp) complex, a common dietary supplement, preferentially crystallizes as the dihydrate (ZnAsp·2HO) from aqueous solution. Under normal conditions the dihydrate easily transforms into the sesquihydrate (ZnAsp·1.5HO).

High-pressure and temperature dependence of the spontaneous resolution of 1,1'-binaphthyl enantiomers.

High pressure increases the temperature of the spontaneous resolution of 1,1'-binaphthyl conformational enantiomers in the crystalline state, which confirms that the enantiomers and racemates are stabilized in the molecular environments in compressed structures. The established pressure-temperature (p-T) preference diagram for the racemate-enantiomer spontaneous crystallization corresponds to a boundary between solid phases, as it is consistent with the Clausius-Clapeyron equation, however, the hysteresis of such a solid-state transformation extends to very high pressure, to 3 GPa, at least according to this study. High-pressure X-ray diffraction study on single crystals of 1,1'-binaphthyl racemate and enantiomer reveals their monotonic compression and structural changes up to 3 GPa.

Phonon-mediated generation of quantum correlations between quantum dot qubits.

We study the generation of quantum correlations between two excitonic quantum dot qubits due to their interaction with the same phonon environment. Such generation results from the fact that during the pure dephasing process at finite temperatures, each exciton becomes entangled with the phonon environment. We find that for a wide range of temperatures quantum correlations are created due to the interaction.

Double helix quinine-based supergelator.

10,11-Didehydroquinine is a simple, low molecular weight supergelator which forms, in nonpolar media, stable chiral organogels composed of unique double-helix nano-sized fibers. A novel gelation mechanism involves a hydrogen bonding network formed by an acidic alkyne proton of the Cinchona gelator and the carbonyl group of ethyl acetate used as a solvent.

Decoherence control by quantum decoherence itself.

We propose a general approach of protecting a two-level system against decoherence via quantum engineering of non-classical multiple superpositions of coherent states in a non-Markovian reservoir. The scheme surprisingly only uses the system-environment interaction responsible for the decoherence and projective measurements of the two-level system. We demonstrate the method on the example of an excitonic qubit in self-assembled semiconductor quantum dots coupled to the super-Ohmic reservoir of acoustic phonons.

Paraesophageal hernia repair followed by cardiac tamponade caused by ProTacks.

We describe a case of cardiac tamponade caused by ProTacks Autosuture used for mesh fixation during a laparoscopic Nissen operation with giant paraesophageal hernia repair. Perforations of the posterior descendent artery and epicardial vein of the right ventricle were caused by ProTacks used for Parietex Composite Mesh fixation. Protruding ProTacks were secured from inside the pericardiac sac with a synthetic vascular patch during emergency sternotomy.

Strong quantum memory at resonant Fermi edges revealed by shot noise.

Studies of non-equilibrium current fluctuations enable assessing correlations involved in quantum transport through nanoscale conductors. They provide additional information to the mean current on charge statistics and the presence of coherence, dissipation, disorder, or entanglement. Shot noise, being a temporal integral of the current autocorrelation function, reveals dynamical information.

Biscationic bicephalic (double-headed) amphiphiles with an aromatic spacer and a single hydrophobic tail.

We report the synthesis and aggregation studies of a homologous family of biscationic "bicephalic" amphiphiles. Each of has a linear alkoxy chain and two trimethylammonium bromide headgroups connected to a benzene ring. Krafft temperatures (T(K)) in water were determined by differential scanning calorimetry (DSC) and conductivity.

[Intraoperative thermography--temperature range on the heart surface during cold cardioplegia].

The paper presents the temperature analysis of the myocardial surface at the cohort of 11 patients with coronary artery disease, who underwent coronary artery bypass grafting with cardiopulmonary bypass. Left and right ventricle temperature changes were registered with Agema Thermovision 900 SW/TE system during cold cardioplegia infusion. Cardioplegia was delivered by the coronary sinus and by the aortic root.