Breakthrough Pain Associated with a Reduction in Serum Buprenorphine Concentration during Dialysis.

Purpose: To describe a case of breakthrough pain associated with a reduction in serum buprenorphine concentration during dialysis.

Methods: Pharmacokinetic sampling of total and free buprenorphine and norbuprenorphine in an 80 year old male undergoing haemodialysis three times per week who received 5760 µg oral and transdermal buprenorphine daily was performed. The patient's serum albumin concentration was 23g/l (reference range: 35-52 g/l).

Copeptin as a serum biomarker of febrile seizures.

Background And Objectives: Accurate diagnosis of febrile seizures in children presenting after paroxysmal episodes associated with fever, is hampered by the lack of objective postictal biomarkers. The aim of our study was to investigate whether FS are associated with increased levels of serum copeptin, a robust marker of arginine vasopressin secretion.

Methods: This was a prospective emergency-setting cross-sectional study of 161 children between six months and five years of age.

Glutaminolysis activates Rag-mTORC1 signaling.

Amino acids control cell growth via activation of the highly conserved kinase TORC1. Glutamine is a particularly important amino acid in cell growth control and metabolism. However, the role of glutamine in TORC1 activation remains poorly defined.