Pseudomonas syringae infectivity correlates to altered transcript and metabolite levels of Arabidopsis mediator mutants.

Rapid metabolic responses to pathogens are essential for plant survival and depend on numerous transcription factors. Mediator is the major transcriptional co-regulator for integration and transmission of signals from transcriptional regulators to RNA polymerase II. Using four Arabidopsis Mediator mutants, med16, med18, med25 and cdk8, we studied how differences in regulation of their transcript and metabolite levels correlate to their responses to Pseudomonas syringae infection.

Marital status and cause-specific mortality: A population-based prospective cohort study in southern Sweden.

The aim was to investigate associations between marital status and mortality with a prospective cohort study design. A public health survey including adults aged 18-80 was conducted with a postal questionnaire in southern Sweden in 2008 (54.1% participation).

Mental distress in relation to police reporting among adolescent victims of robbery. A population-based study in southern Sweden.

•Robberies as well as mental distress have increased among adolescents in Sweden.•This study on school students in southern Sweden was population-based with a high response rate.•Half of the robbed adolescents abstained from police reporting.

Leisure-time physical activity, desire to increase physical activity, and mortality: A population-based prospective cohort study.

The aim was to investigate associations between leisure-time physical activity (LTPA) and mortality, and associations between desire to increase LTPA and mortality within the low LTPA group. A public health survey questionnaire was sent in 2008 to a stratified random sample of the population aged 18-80 in southernmost Sweden, yielding a 54.1% response rate.

Occupational role and COVID-19 among foreign-born healthcare workers in Sweden: a registry-based study.

Background: Many studies report that foreign-born healthcare workers (HCWs) in high-income countries have an elevated risk of COVID-19. However, research has not yet specifically evaluated the distribution of COVID-19 among foreign-born workers in different healthcare work groups. We examined the risk of COVID-19 infection and hospitalization among foreign-born HCWs in different occupational roles in Sweden.

Poor psychological health and 8-year mortality: a population-based prospective cohort study stratified by gender in Scania, Sweden.

Objectives: We investigated gender differences in the association between mortality and general psychological distress (measured by 12-item General Health Questionnaire, GHQ-12), as an increased mortality risk has been shown in community studies, but gender differences are largely unknown.

Setting: We used data from a cross-sectional population-based public health survey conducted in 2008 in the Swedish region of Skåne (Scania) of people 18-80 years old (response rate 54.1 %).

Mapping nonlocal relationships between metadata and network structure with metadata-dependent encoding of random walks.

Integrating structural information and metadata, such as gender, social status, or interests, enriches networks and enables a better understanding of the large-scale structure of complex systems. However, existing approaches to augment networks with metadata for community detection only consider immediately adjacent nodes and cannot exploit the nonlocal relationships between metadata and large-scale network structure present in many spatial and social systems. Here, we develop a flow-based community detection framework based on the map equation that integrates network information and metadata of distant nodes and reveals more complex relationships.

An intersectional analysis of sociodemographic disparities in Covid-19 vaccination: A nationwide register-based study in Sweden.

Background: Studies on sociodemographic disparities in Covid-19 vaccination uptake in the general population are still limited and mostly focused on older adults. This study examined sociodemographic differences in Covid-19 vaccination uptake in the total Swedish population aged 18-64 years.

Methods: National Swedish register data within the SCIFI-PEARL project were used to cross-sectionally investigate sociodemographic differences in Covid-19 vaccination among Swedish adults aged 18-64 years (n = 5,987,189) by 12 October 2021.

Cross-sectional associations of optimism with artery calcification and function: The SCAPIS study.

Background: An increasing amount of research indicates that positive psychological factors, such as optimism, might be beneficial for cardiovascular health. However, most studies have focused on cardiovascular events. The present study aimed to investigate associations between optimism and subclinical outcomes related to cardiovascular health.

Health locus of control and all-cause, cardiovascular, cancer and other cause mortality: A population-based prospective cohort study in southern Sweden.

The aim was to investigate associations between health locus of control (HLC) and all-cause, cardiovascular (CVD), cancer and other cause mortality. A public health postal questionnaire was distributed in the autumn of 2008 to a stratified random sample of the 18-80 year old adult population in Scania in southernmost Sweden. The participation rate was 54.

The social patterning of Covid-19 vaccine uptake in older adults: A register-based cross-sectional study in Sweden.

Background: A broad vaccination coverage is crucial for preventing the spread of Covid-19 and reduce serious illness or death. The aim of this study was to examine social inequalities in Covid-19 vaccination uptake as of 17th May 2021 among Swedish adults aged ≥ 60 years.

Methods: The study population comprised a general population cohort aged 60 years or older ( = 350,805), representative of the Swedish population.

Social capital, the miniaturization of community, traditionalism and mortality: A population-based prospective cohort study in southern Sweden.

Objectives: To investigate associations between social capital, miniaturization of community and traditionalism and all-cause, cardiovascular (CVD), cancer and other causes mortality.

Study Design: Prospective cohort study.

Methods: The 2008 public health survey in Scania in the southernmost part of Sweden was conducted with a postal questionnaire posted to a stratified random sample aged 18-80.

Life satisfaction and coronary atherosclerosis: The SCAPIS study.

Background: There is an increasing interest in the potential health benefits of positive psychological states, especially with regard to cardiovascular health. Life satisfaction is thought to be a constituent component of psychological well-being; however, among the few previous studies that have investigated its associations with early stages of the cardiovascular disease process, only one small study has focused on coronary atherosclerosis. The present study aimed to explore associations between life satisfaction and coronary artery disease.

Socioeconomic and environmental patterns behind H1N1 spreading in Sweden.

Identifying the critical factors related to influenza spreading is crucial in predicting and mitigating epidemics. Specifically, uncovering the relationship between epidemic onset and various risk indicators such as socioeconomic, mobility and climate factors can reveal locations and travel patterns that play critical roles in furthering an outbreak. We study the 2009 A(H1N1) influenza outbreaks in Sweden's municipalities between 2009 and 2015 and use the Generalized Inverse Infection Method (GIIM) to assess the most significant contributing risk factors.

A multiscale view of the Phanerozoic fossil record reveals the three major biotic transitions.

The hypothesis of the Great Evolutionary Faunas is a foundational concept of macroevolutionary research postulating that three global mega-assemblages have dominated Phanerozoic oceans following abrupt biotic transitions. Empirical estimates of this large-scale pattern depend on several methodological decisions and are based on approaches unable to capture multiscale dynamics of the underlying Earth-Life System. Combining a multilayer network representation of fossil data with a multilevel clustering that eliminates the subjectivity inherent to distance-based approaches, we demonstrate that Phanerozoic oceans sequentially harbored four global benthic mega-assemblages.

Impacts of Oxazepam on Perch () Behavior: Fish Familiarized to Lake Conditions Do Not Show Predicted Anti-anxiety Response.

A current theory in environmental science states that dissolved anxiolytics (oxazepam) from wastewater effluents can reduce anti-predator behavior in fish with potentially negative impacts on prey fish populations. Here, we hypothesize that European perch () populations being exposed to oxazepam show reduced anti-predator behavior, which has previously been observed for exposed isolated fish in laboratory studies. We tested our hypothesis by exposing a whole-lake ecosystem, containing both perch (prey) and northern pike (; predator), to oxazepam while tracking fish behavior before and after exposure in the exposed lake as well as in an unexposed nearby lake (control).

Regularities in species' niches reveal the world's climate regions.

Climate regions form the basis of many ecological, evolutionary, and conservation studies. However, our understanding of climate regions is limited to how they shape vegetation: they do not account for the distribution of animals. Here, we develop a network-based framework to identify important climates worldwide based on regularities in realized niches of about 26,000 tetrapods.

Mapping flows on bipartite networks.

Mapping network flows provides insight into the organization of networks, but even though many real networks are bipartite, no method for mapping flows takes advantage of the bipartite structure. What do we miss by discarding this information and how can we use it to understand the structure of bipartite networks better? The map equation models network flows with a random walk and exploits the information-theoretic duality between compression and finding regularities to detect communities in networks. However, it does not use the fact that random walks in bipartite networks alternate between node types, information worth 1 bit.

Mapping flows on sparse networks with missing links.

Unreliable network data can cause community-detection methods to overfit and highlight spurious structures with misleading information about the organization and function of complex systems. Here we show how to detect significant flow-based communities in sparse networks with missing links using the map equation. Since the map equation builds on Shannon entropy estimation, it assumes complete data such that analyzing undersampled networks can lead to overfitting.

Health locus of control and mortality: a population-based prospective cohort study.

Objectives: The objective of the study was to estimate associations between health locus of control (HLC) and mortality.

Study Design & Methods: The public health survey in Scania 2008 was linked to the Swedish cause of death register. In this study of 10,757 men and 12,322 women aged 18-80 years, 421 men and 235 women died during the 5.

Sexual orientation and all-cause mortality: A population-based prospective cohort study in southern Sweden.

Objectives: To investigate associations between sexual orientation and all-cause mortality.

Study Design: Prospective cohort study.

Methods: The 2008 public health survey in Scania was conducted with a postal questionnaire later linked to 9.