Sevoflurane improves electrophysiological recovery of rat hippocampal slice CA1 pyramidal neurons after hypoxia.

Sevoflurane is a volatile anesthetic agent that reduces cerebral metabolism and thereby may reduce neuronal damage during energy deprivation. We have examined the effect of sevoflurane on hypoxic neuronal damage in rat hippocampal slices. Slices were subjected to 0%, 2%, or 4% sevoflurane 10 minutes before, during, and 10 minutes after hypoxia.