Dihydrofolate reductase inhibitory potential of 1H-indole-based-meldrum linked 1H-1,2,3-triazoles as new anticancer derivatives: In-vitro and in-silico studies.

In this present work, we describe the syntheses of a new series of 32 1H-indole-based-meldrum linked 1H-1,2,3-triazole derivatives (2-13, 15a-15f, 16a-16f, 17a-17f and 19a, 19b, 20a), which constitute a new class of 1H-1,2,3-triazoles. Compounds 15a-15f, 16a-16f, 17a-17f have been prepared by employing "click" reactions between substituted 1H-indole-based meldrum alkynes (11, 12 and 13) and substituted aromatic azides (14a-14f) in the presence of copper iodide (CuI) and Hünig's base. Then, the synthesis of compounds 19, 20 through decomposition of meldrum moiety.

Serological diagnosis of in mothers and their neonate referred to selected teaching hospitals, Tehran, Iran, 2020.

Toxocariasis is a common zoonotic parasitic disease, primarily caused by the larvae of or . Humans become infected through accidental ingestion of infective eggs in soil contaminated with feces of infected animals, or by consuming undercooked meat from paratenic hosts harboring larvae. This cross-sectional study aimed to evaluate the seroprevalence of spp.

The global prevalence of among red foxes (): A systematic review and meta-analysis.

Red foxes play a crucial role in the life cycle and transmission of zoonotic pathogens, including ; however, comprehensive information on the prevalence of in red foxes () is lacking. In this meta-analysis we aimed to evaluate the global and regional prevalence of among red foxes. We searched PubMed, Scopus, and Google Scholar for studies reporting prevalence of in red foxes up to April 1, 2024.

Anti-Toxoplasma gondii IgG seroprevalence in the general population in Iran: A systematic review and meta-analysis, 2000-2023.

Toxoplasmosis ranks among the most prevalent parasitic diseases globally. It seems that chronic toxoplasmosis is associated with several neuropsychiatric and other harmful effects in infected people, therefore, there is a need to investigate the prevalence of toxoplasmosis across various world regions. In this study, we conducted a meticulous meta-analysis to estimate the seroprevalence of anti-Toxoplasma gondii IgG antibodies within the general population in Iran (GPI).

Anti-Nociceptive Effect of Sufentanil Polymeric Dissolving Microneedle on Male Mice by Hot Plate Technique.

Background: Despite the widespread use of opioids to manage severe pain, its systemic administration results in side effects. Among the subcutaneous and transdermal drug delivery systems developed to deal with adverse effects, microneedles have drawn attention due to their rapid action, high drug bioavailability, and improved permeability. Sufentanil (SUF) is an effective injectable opioid for treating severe pain.

Exosomes, and the potential for exosome-based interventions against COVID-19.

Since late 2019, the world has been devastated by the coronavirus disease 2019 (COVID-19) induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with more than 760 million people affected and ∼seven million deaths reported. Although effective treatments for COVID-19 are currently limited, there has been a strong focus on developing new therapeutic approaches to address the morbidity and mortality linked to this disease. An approach that is currently being investigated is the use of exosome-based therapies.

Association between Alzheimer's disease and Toxocara infection/exposure: a case-control study.

Background: Infections may contribute to Alzheimer's disease (AD) risk. Limited evidence suggests Toxocara spp. infection/exposure could influence AD development.

GraphT-T (V1.0Beta), a program for embedding and visualizing periodic graphs in 3D Euclidean space.

Following the work of Day & Hawthorne [Acta Cryst. (2022), A78, 212-233] and Day et al. [Acta Cryst.

Bond topology of chain, ribbon and tube silicates. Part II. Geometrical analysis of infinite 1D arrangements of (TO) tetrahedra.

In Part I of this series, all topologically possible 1-periodic infinite graphs (chain graphs) representing chains of tetrahedra with up to 6-8 vertices (tetrahedra) per repeat unit were generated. This paper examines possible restraints on embedding these chain graphs into Euclidean space such that they are compatible with the metrics of chains of tetrahedra in observed crystal structures. Chain-silicate minerals with T = Si (plus P, V, As, Al, Fe, B, Be, Zn and Mg) have a grand nearest-neighbour ⟨T-T⟩ distance of 3.

Thermal properties of novel phase change materials based on protic ionic liquids containing ethanolamines and stearic acid for efficient thermal energy storage.

In the field of energy harvesting, phase change materials (PCMs) hold great promise. 2-hydroxyethylammonium stearate ([HEA]Ste), bis(2-hydroxyethyl)ammonium stearate ([DHEA]Ste), and tris(2-hydroxyethyl)ammonium stearate ([THEA]Ste) ionic liquids (ILs) demonstrate promising capabilities to enhance thermal energy storage (TES) performance within the 30-100 °C temperature range. This research presents these ILs as PCMs for the first time, emphasizing their environmentally friendly characteristics, safety profile, and cost-effectiveness.

The global prevalence of Trichuris trichiura infection in humans (2010-2023): A systematic review and meta-analysis.

This systematic review and meta-analysis study aimed to evaluate global Trichuris infection prevalence, assessing progress towards the WHO's 2030 target. We searched international databases from 2010-2023, categorizing data by regions and socio-economic variables using a random-effects model. Analyzing 757 articles covering 7154,842 individuals from 78 countries, the study found a pooled global prevalence of (6.

Identification of four novel mutations in VSP13A in Iranian patients with Chorea-acanthocytosis (ChAc).

Chorea-acanthocytosis (ChAc) is a rare autosomal recessive neurodegenerative disorder characterized by a variety of involuntary movements, predominantly chorea, and the presence of acanthocytosis in peripheral blood smears. ChAc is caused by mutations in the vacuolar protein sorting-associated protein 13A (VPS13A) gene. The aim of the present study was to conduct a clinical and genetic analysis of five patients with suspected ChAc in Iran.

Exploring natural anthraquinones as potential MMP2 inhibitors: A computational study.

Objective: Matrix metalloproteinase-2 (MMP2) plays a significant role in cleaving extracellular matrix components, leading to many cancer cells' progression and invasion behavior. Therefore, MMP2 inhibition may hold promise for cancer treatment. Anthraquinones have shown antineoplastic effects, some of which have been used in clinical practice as anticancer drugs.

Evaluation of the association between inflammatory markers and the prognosis of Covid-19.

Introduction: Coronavirus disease 2019 (COVID-19) triggers the immune system and causes changes in the serum level of inflammatory markers such as erythrocyte sedimentation rate (ESR), C-reactive protein, ferritin, interleukin-6, LDH, D-dimer, and procalcitonin (PCT); in this study, we investigate the association between the serum level of inflammatory markers and the prognosis of COVID-19, which included mortality and intensive care unit (ICU) admission of patients.

Methods: This cross-sectional study was conducted on 200 COVID-19 patients hospitalized at Ayatollah Rouhani Hospital, Babol, from March 2020 to March 2021. Demographic indicators and inflammatory markers were recorded in the questionnaire and were investigated based on disease outcome, length of hospitalization, need for non-invasive ventilation (NIV), and need for hospitalization in the ICU and ventilator.

Hepatitis C infection seroprevalence in pregnant women worldwide: a systematic review and meta-analysis.

Background: Monitoring progress towards the WHO global target to eliminate hepatitis C virus (HCV) infection by 2030, entails reliable prevalence estimates for HCV infection in different populations. Little is known about the global burden of HCV infection in pregnant women. Here, for the first time to our knowledge, we estimated the global and regional seroprevalence of HCV antibody (Ab) and determinants in pregnant women.

Novel protic ionic liquids-based phase change materials for high performance thermal energy storage systems.

Phase change materials (PCMs) are an important class of innovative materials that considerably contribute to the effective use and conservation of solar energy and wasted heat in thermal energy storage systems (TES). The performance of TES can be improved by using environmentally friendly PCMs called ionic liquids (ILs) based on ethanolamines and fatty acids. The 2-hydroxyethylammonium, bis(2-hydroxyethyl)ammonium, and tris(2-hydroxyethyl)ammonium palmitate ILs, which function is in the temperature range of 30-100 °C and provide a safe and affordable capacity, are introduced in this study for the first time as PCMs.

Ag/ZnO core-shell NPs boost photosynthesis and growth rate in wheat seedlings under simulated full sun spectrum.

Breeding programs rely on light wavelength, intensity, and photoperiod for rapid success. In this study, we investigated the ability of Ag/ZnO nanoparticles (NPs) to improve the photosynthesis and growth of wheat under simulated full solar spectrum conditions. The world population is increasing rapidly, it is necessary to increase the number of crops in order to ensure the world's food security.

Meldrum-Based-1-1,2,3-Triazoles as Antidiabetic Agents: Synthesis, α-Glucosidase Inhibition Activity, Molecular Docking Studies, and Approach.

A series of novel alkyl derivatives () and 1-1,2,3-triazole analogues () of Meldrum's acid were synthesized in a highly effective way by using chemistry and screened for in vitro -glucosidase inhibitory activity to examine their antidiabetic potential. H NMR, C-NMR, and high-resolution electrospray ionization mass spectra (HR-ESI-MS) were used to analyze each of the newly synthesized compounds. Interestingly, these compounds demonstrated high to moderate α-glucosidase inhibitory potency having an IC range of 4.

Chlamydia pneumonia infection and risk of multiple sclerosis: A meta-analysis.

Background: The role of infectious agents, including Chlamydia pneumoniae (Cpn), in the development of multiple sclerosis (MS), is still a matter of major contention.

Objective: This meta-analysis study aimed to assess the actual involvement of Cpn in MS development.

Methods: We undertook a search of international scientific databases to identify eligible studies.

Trichomonas vaginalis infection and risk of cervical neoplasia: A systematic review and meta-analysis.

Objectives: The evidence in the literature regarding the relationship between Trichomonas vaginalis (TV) infection and cervical neoplasia is conflicting. The main aim of this study was to evaluate the magnitude of the risk of cervical neoplasia associated with TV infection.

Methods: A meta-analysis of observational studies, which provided raw data on the association of TV infection with cervical neoplasia, was performed.

High-efficiency upconversion process in cobalt and neodymium doped graphene QDs for biomedical applications.

Multiphoton absorbing upconversion nanoparticles are emerging as bioimaging materials but are limited by the low quantum yield of their visible fluorescence. This article contains colloids of graphene quantum dots (GQDs), Neodymium, and Cobalt doped Graphene Quantum dots (Co-GQDs and Nd-GQDs) surrounded by carboxylic acids are synthesized which especially are suitable for bio applications; in this way, carboxylic acid groups exchanged by Amoxicillin as an antibiotic with bactericidal activity. The XRD diffraction method, TEM microscope, UV-Vis, and photoluminescence spectroscopies characterize the synthesized materials.

Strongyloides coinfection in COVID-19 patients treated with corticosteroids: A systematic review.

The COVID-19 pandemic linked to the virus SARS-CoV-2, which began in China, affected ∼765 million people as of 30 April 2023. The widespread use of corticosteroids for the symptomatic treatment of COVID-19 could lead to the reactivation of infections of opportunistic pathogens, including Strongyloides. We sought to determine the clinical symptoms and demographic characteristics of SARS-CoV-2-Strongyloides co-infection, particularly in patients with severe disease and being treated with immunosuppressive drugs.

Switchable Ultra-Wideband All-Optical Quantum Dot Reflective Semiconductor Optical Amplifier.

A comprehensive study has been conducted on ultra-broadband optically pumped quantum dot (QD) reflective semiconductor optical amplifiers (QD-RSOAs). Furthermore, little work has been done on broadband QD-RSOAs with an optical pump. About 1 μm optical bandwidth, spanning 800 nm up to 1800 nm, is supported for the suggested device by superimposing nine groups of QDs.