Publications by authors named "Rossylna O"
Article Synopsis
- Current markers for oral squamous cell carcinoma (OSCC) are often inaccurate, potentially resulting in poor treatment choices; new markers could improve patient treatment and survival rates.
- The study evaluates the potential of miRNA levels in saliva (specifically miR-21, miR-155, and miR-375) as prognostic indicators for the effectiveness of neoadjuvant chemotherapy (NACT) in patients with stage II-IV OSCC.
- Results show that miR-21 and miR-155 levels are higher in OSCC patients compared to healthy individuals, and patients who respond well to NACT have distinct miRNA expression patterns, suggesting these could serve as valuable biomarkers for treatment response.
Background: The discovery of new markers for colorectal cancer (CRC) is of paramount importance for improving the diagnosis, prognosis, and treatment of this disease. CRC is the third most common cancer worldwide and the second leading cause of cancer-related deaths. Early detection and treatment are crucial for improving patient outcomes, but current screening methods are not foolproof.
View Article and Find Full Text PDFUnlabelled: Breast cancer (BC) remains the most prevalent tumor and the leading cause of death among women worldwide, despite the advancements in diagnosis and new treatments. A significant challenge in BC treatment is the acquired or de novo resistance of tumors to systemic therapy. To overcome this obstacle, personalized treatment is needed, with a focus on finding biomarkers capable of predicting the response to therapy.
View Article and Find Full Text PDFBackground: Oral squamous cell carcinoma (OSCC) is one of the most common types of cancer worldwide. Disco- vering novel prognostic markers for OSCC can improve treatment outcomes by allowing for more effective therapy strategies.
Aim: To identify the prognostic value of CDKN2A (p16INK4a) and miRNAs involved in its regulation as markers of OSCC.
Background: Hormonal therapy is one of the main methods of comprehensive treatment of patients with locally advanced breast cancer (BC). Despite the intensive search for molecules associated with the aggressiveness of the tumor process, currently there are no reliable markers predicting response to neoadjuvant hormonal therapy (NHT).
Aim: To investigate the correlation between miR-125b-2, -155, -221, -320a expression in tumor tissue and HER2/neu status and response to tamoxifen treatment in BC patients.
Unlabelled: Renal cell carcinoma (RCC) is one of the most common solid tumors in adults. There is a lack of reliable prognostic and predictive biomarkers for RCC course. Dysregulation of miRNAs expression has been reported to be involved in RCC progression.
View Article and Find Full Text PDFBackground: Renal cell carcinoma (RCC) is one of the most common solid tumors in adults highly resistant to conventional therapies. The expression profile of a number of miRNAs correlates with RCC response to chemotherapeutic agents.
Aim: To identify the association of tumor miRNAs expression with neoadjuvant treatment response in patients with RCC.
The article is devoted to the comprehensive analysis of scientific, practical and legal issues of personalized medicine that is a rapidly developing science-driven approach to healthcare. It is concluded that there is lack of general legal framework for the encouragement of scientific researches and practical implementation in this field. The article shows foreign experience and prospects for the introduction of personalized medicine as a key concept of healthcare system, which is based on a selection of diagnostic, therapeutic and preventive measures that would be the most effective for a particular person in view of individual characteristics.
View Article and Find Full Text PDF