Phylogeographical and evolutionary history of virus; a question of timescales?

Aim of this study was to reconstruct the phylogeography of virus (VARV) in the XX century, using 47 VARV whole genome sequences available in public databases, through two different methods for ancestral character reconstruction: a frequently used Bayesian framework and a fast maximum-likelihood (ML) based method. The substitution rate of the whole VARV genome was estimated to be between 6.7×10 and 1.