PATH classification: a proposal for patients with HNSCC treated with salvage surgery.

Purpose: The aim of this study is to propose a classification for patients with recurrent head and neck squamous cell carcinoma (HNSCC) treated with salvage surgery based on the location of the primary tumor and data commonly found in the pathological report of the resection.

Methods: Retrospective study of 665 patients with HNSCC treated with a salvage surgery after a local and/or regional recurrence of the tumor.

Results: We propose a new postoperative classification for patients with recurrent HNSCC treated with salvage surgery.

Oncological results of salvage treatment in patients with oropharynx carcinoma treated with radiotherapy.

Objective: To evaluate the possibilities of salvage after local recurrence in patients with oropharyngeal carcinomas treated with radiotherapy, and to analyse the prognostic factors related to the final control of the disease.

Methods: Retrospective study of 596 patients with oropharyngeal carcinoma treated with radiotherapy during the period 1991-2018.

Results: One hundred and eighty-one patients (30.

Results of radiotherapy in oropharyngeal carcinomas.

Objective: To present the results of radiotherapy treatment in patients with oropharyngeal carcinomas.

Material And Methods: Retrospective study of a cohort of 359 patients treated with radiotherapy, including chemo- and bio-radiotherapy, during the period 2000-2019. Information on human papillomavirus (HPV) status was available for 202 patients, of whom 26.

External validation of the H-index (host index) in patients with head and neck squamous cell carcinomas.

Background: The aim of the current study is to perform an external validation of the prognostic capacity of the H-index in patients with head and neck squamous cell carcinoma (HNSCC).

Methods: Retrospective study of 835 patients with HNSCC located in the oral cavity, oropharynx, hypopharynx, or larynx.

Results: When applying the cutoffs proposed in the original description of the H-index (1.

Relationship between the transcriptional expression of PIM1 and local control in patients with head and neck squamous cell carcinomas treated with radiotherapy.

Purpose: Proviral integration site for Moloney murine leukemia virus (PIMs) are proto-oncogenes encoding serine/threonine kinases that phosphorylate a variety of substrates involved in the regulation of cellular processes. Elevated expression of PIM-1 has been associated with poor prognosis in several types of cancer. There are no studies that have analyzed the response to radiotherapy in patients with head and neck squamous cell carcinoma (HNSCC) according to the expression of PIM-1.

Causes of long-term mortality in patients with head and neck squamous cell carcinomas.

Purpose: After treatment of a head and neck squamous cell carcinoma (HNSCC), patients with an adequate control of the tumor have a decreased overall survival when compared to age- and gender-matched controls in the general population. The aim of our study was to analyze the causes of long-term mortality in patients with HNSCC.

Methods: We carried out a retrospective study of 5122 patients with an index HNSCC treated at our center between 1985 and 2018.