Early rise in central venous pressure during a spontaneous breathing trial: A promising test to identify patients at high risk of weaning failure?

Background: The spontaneous breathing trial (SBT) assesses the risk of weaning failure by evaluating some physiological responses to the massive venous return increase imposed by discontinuing positive pressure ventilation. This trial can be very demanding for some critically ill patients, inducing excessive physical and cardiovascular stress, including muscle fatigue, heart ischemia and eventually cardiac dysfunction. Extubation failure with emergency reintubation is a serious adverse consequence of a failed weaning process.

[Reference values for the 6-minutes walking test in healthy Chilean children].

Background: The 6-minutes walking test (6WT) is the ideal submaximal test for the evaluation and follow-up of patients with chronic respiratory diseases. There are no reference values (RV) for Chilean children using the American Thoracic Society guidelines.

Aim: To generate 6WT reference values for Chilean children aged 6 to 14 years.

Multiplex PCR for diagnosis of enteric infections associated with diarrheagenic Escherichia coli.

A multiplex PCR for detection of three categories of diarrheagenic Escherichia coli was developed. With this method, enterohemorrhagic E. coli, enteropathogenic E.