Effect of age, family history of prostate cancer, prostate enlargement and seasonality on PSA levels in a contemporary cohort of healthy Italian subjects.

We assessed the joint effect of age at enrollment, age at follow-up, family history of prostate cancer, prostate enlargement and seasonality on prostate-specific antigen (PSA) estimated through log-normal mixed-effects modeling in an Italian cohort of healthy, 45- to 65-year-old subjects over a 4-year period. The median ratio was used as the measure of effect. Median and mean baseline PSA were 0.

Late-onset incontinence in a cohort of radical prostatectomy patients.

A cohort of 235 subjects, who underwent radical prostatectomy from 1994 to 2002, completely continent at the 2-year follow up and with the last follow-up visit in 2009, was examined to assess incidence and risk factors of late-onset incontinence. Median follow up was 100 months, range 84-176. At the last follow-up visit, 209 (89%) maintained continence, and 26 (11%) became incontinent.

Predictors of symptomatic lymphocele after lymph node excision and radical prostatectomy.

Objectives: To identify the prognostic factors of symptomatic lymphocele.

Methods: From January 2004, 359 patients underwent pelvic lymph node excision during radical prostatectomy at our center, of whom, 347 were followed up for > or = 6 months.

Results: At a median follow-up of 14.

Prognostic factors of persistently detectable PSA after radical prostatectomy.

Objectives: To determine predictive factors of detectable prostate-specific antigen (PSA) in patients submitted to radical prostatectomy (RP) and to define the prognostic role of this event.

Methods: A total of 318 patients who underwent RP between 2002 and 2007 were selected from our prospective database. Selection criteria were: no neo-adjuvant therapy; surgical specimens analyzed and reviewed according to a standardized protocol by two pathologists; clinical stage T1,T2 or T3 N0; pathological stage T2-3/N0-1.

Omission of lymphadenectomy in low risk prostate cancer.

Unlabelled: THE AIM of the present study was to evaluate if lymphadenectomy could be safely spared in low risk prostate cancer (PC) patients.

Patients And Methods: From 5/1998 to 10/2005, 100 patients with low risk prostate cancer who had undergone radical prostatectomy (RP) and did not have positive surgical margins were selected. The series included 34 patients submitted to lymphadenectomy including the iliac and obturatory nodes without documented nodal metastasis.

Implementation of a molecular epidemiology approach to human pleural malignant mesothelioma.

The carcinogenic effect of asbestos has been reported in the literature since 40 years, and early studies describing the epidemic occurrence of malignant mesothelioma (MM) in asbestos workers, have become a paradigm of occupational cancer research. Research on MM was abandoned for many years since MM was considered as an asbestos-related disease, interesting only from a perspective of disease control and preventive policies. The introduction of new biological endpoints in the epidemiological studies has boosted research in the field, providing new tools for the study of emerging priority in cancer research and in public health.