Publications by authors named "Ross MacNicholas"
Image-guided tumour ablation is a minimally invasive treatment for early stage hepatocellular carcinoma (HCC). Our study reviews the complications and long term outcomes in patients treated at a tertiary referral centre. Retrospective study.
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- There is a growing shortage of ideal donor organs, leading to longer wait times for liver transplants, prompting teams to expand criteria for acceptable donor organs.
- Researchers studied a 2-year period at a single institution, analyzing patients' decisions to accept or refuse different types of extended criteria liver grafts based on factors like age, sex, and disease characteristics.
- Findings showed that most patients were open to accepting these grafts, with older patients and those with certain conditions (like hepatocellular carcinoma) more likely to accept, indicating the need to reassess patient consent as their health status changes on the waitlist.
Background: Alcoholic liver disease (ALD) is a major cause of both liver cirrhosis and hepatocellular carcinoma (HCC) in Ireland.
Aims: The aim of the study was to identify the epidemiological profile, temporal trends, development of complications and mortality arising from inpatient care episodes linked to ALD in Ireland from 2007 to 2016.
Methods: This was a national retrospective study that analysed data on patient discharges from hospitals across Ireland.
Article Synopsis
- Severe alcoholic hepatitis (sAH) has a poor prognosis and lacks effective treatments, leading to interest in early transplantation and the use of C3A cells in extracorporeal cellular therapy (ELAD) to improve patient survival.
- A clinical study involving 203 adults with sAH compared standard of care (SOC) to SOC plus 3-5 days of ELAD treatment, but found no significant difference in overall survival between the two groups after 91 days.
- While the study did not meet its main goals, there was a positive trend in survival for patients with a MELD score <28, prompting further research into ELAD treatment in younger patients with better renal function and milder coagulopathy.
An update on the diagnosis and management of Budd-Chiari syndrome.
Expert Rev Gastroenterol Hepatol
December 2012
Budd-Chiari syndrome is a rare disorder caused by hepatic venous outflow obstruction and resulting hepatic dysfunction. Despite a lack of prospective randomized trials, much progress has been made in its management over the last 20 years. The main goals of treatment are to ameliorate hepatic congestion and prevent further thrombosis.
View Article and Find Full Text PDFGallbladder wall variceal haemorrhage with associated rupture: a rare cause of mortality in the cirrhotic patient.
Eur J Gastroenterol Hepatol
August 2009
Gallbladder wall varices are unusual ectopic varices, which occur in the setting of portal hypertension, usually but not universally associated with portal vein thrombosis. Rupture of these varices may lead to life-threatening intra abdominal haemorrhage and is associated with a high mortality rate. We report a case of gallbladder wall variceal haemorrhage in a cirrhotic patient with patent transjugular intrahepatic portosystemic shunt, which resulted in death.
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