Publications by authors named "Roslyĭ I"

It has been shown that cerebral processes are characterized by fine physiological meteosensitivity. Under ordinary conditions, this manifests itself in correlations between human EEG parameters and the geophysical factors: wind regime, temperature, atmospheric pressure, and relative air humidity. The biometeorological properties of EEG rhythms of a human increase with their increasing frequency in the order delta--theta--alpha--beta irrespective of age.

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The Creatine kinase (CK) SYSTEM represents key in a power exchange mediators the structure capable to plural interactions with the majority energy making (Glycolysis and mitochondriuns) and energy consuming (ATPases) structures at use of one multifunctional metabolits--creatine and providing transport macroergs inside a cell. Mitochondrions CK provides synthesis creatine phosphates (CP) from cytoplasmic creatine and energy mitochondriums ATP. CP energetically also is structurally more favourable than ATphi.

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Neovir, an inductor of interferon-alpha, was injected intramuscularly to 15 male patients aged 16-44 years with diagnosed acute viral hepatitis in a dose of 250 mg a day, 2-3 times a week, for 3 months. By the end of the therapy hepatitis C virus RNA could still be isolated in 84.6% of the patients; the values of AlaT, AsaT and alkaline phosphatase exceeded the normal levels twofold.

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The data available in the literature and the authors' own findings on possible causes, mechanisms, and modes of enzyme appearance in the blood are analyzed. Blood enzymes has been ascertained to play a major role in maintaining the body's metabolism. Clinical and experimental findings make it possible to conclude that it is biologically expedient for enzymemia to develop both in pathology and that blood enzymes are in the normal range.

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Fifteen male patients with acute hepatitis C aged 16-44 years were treated with neovir, an interferon inducer, administered intramuscularly in a daily dose of 250 mg 2-3 times a week for 3 months. By the end of this therapy the RNA of hepatitis C virus could still be detected in 84.6% of the patients, the characteristics of ALT, AST and alkaline phosphatase exceeded the norm more than twofold.

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Acute and subacute administration of tetrindol resulted in pharmacological effects and biochemical changes which can be attributed to manifestations of toxic effect and activation of the detoxication systems.

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Aim: To study chemiluminescence (CL) of polymorphonuclear neutrophils (PMNL) in peripheral blood of patients with acute mild and moderate dysentery caused by Shig. Flexneri in response to Re- and S-chemotype lipopolysaccharide (LPS) Sh. Flexneri and agonists fMLP, PMA and OZ.

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Aim: To study clinical and laboratory manifestations of acute viral hepatitis C in parenteral drug addicts.

Materials And Methods: Acute viral hepatitis C (AVHC) was diagnosed in 114 patients included in the trial by serological evidence and virus RNA determination at polymerase chain reaction. Among the examinees there were 63 addicts and 51 non-addicts.

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Aim: To specify myocardial affection in adult patients with toxic diphtheria (TD).

Materials And Methods: Along with routine clinical examination 150 patients with toxic diphtheria underwent ECG, echo-CG and biochemical tests. 22, 81, 26, 14 and 7 patients had subtoxic TD, toxic form of the first degree, second degree, third degree and hemorrhagic TD, respectively.

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The data of detailed biochemical analysis of the schizophrenic patients with febrile psychoses suggest the differences in the blood enzymatic spectrum between different types of this disease (spontaneous febrile schizophrenia, malignant neuroleptic syndrome, generalised allergic reaction). The activity of the plasma enzymes is correlated with febrile syndrome and clinical manifestation of the disease, its highest level is observed in patients with malignant neuroleptic syndrome. The role of the cytolysis in clinical manifestation different types of psychoses is discussed.

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Hepatic lesions were analyzed in 33 patients with HIV-infection. The patients were divided into two groups by the disease stage: early (stage IIB, IIIA, n = 12) and late (stage IIIB and IIIC, n = 21). Markers of hepatitis A, B and C were found in 42.

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Within 1987-1995 the authors observed 16 cases of tuberculosis in HIV-infected patients which accounted for 26.7% of AIDS patients treated by them. 14 cases were diagnosed intravitally, 2 postmortem.

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In 63 children with severe meningococcal infection (MI) and meningitides of another origin red cell metabolism was studied: levels of ATP, ADP, AMP, ATP/ADP, ATP/AMP, energetic charge, 2,3-DPG, FAD, piruvate, lactate, activity of lactate dehydrogenase, piruvate kinase, glucose-6-phosphate dehydrogenase, glutatione reductase, Mg2+, Na+, K(+)-dependent ATPase. All the disease periods were characterized by combined pathobiochemical shifts of different degree typical for varying metabolic systems and correlating with the infection severity. The discussion covers pathogenetic and clinical significance of red cell metabolism shifts in patients with MI and purulent meningitides.

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The red blood cell metabolic parameters ATP, ADP, sigma AN, ATP/ADP, ATP/ATP, energy charge, PAD, 2,3-DPH, Pn were studied in 106 patients with generalized meningococcus infection (GMI) and meningitis of other etiology over their natural history. There was a typical adaptative red blood cell response that featured glycolytic stimulation on hypoxia that ran with impaired red blood cell energy metabolism (RBCEM), negative energy balance. It was the most pronounced at the peak of disease.

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The paper analyzes 10-year experience in making experimental observations and clinically using electromagnetic fields (EMF) biologically adequate to man. Basic investigations of the electromechanical process that lead to the occurrence of currents in the bone tissue and blood vascular walls in their functional deformation were conducted. They showed that the piezoelectric effect is the most marked in the intact bone tissue.

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Red cell metabolism (RCM) was examined in 63 patients with severe and complicated meningococcal infection and purulent meningitis of another etiology. There were complex pathobiochemical shifts with changes in glycolysis (in activity of lactate dehydrogenase, piruvatkinase, in the amount of piruvate, lactate and 2,3-DPG), antioxidant status (in the activity of glucose-6-phosphate-dehydrogenase, glutathione reductase), Mg+2, Na+, K(+)-dependent ATPase. Primary depression of red cell metabolism changed for compensatory activation for hypoxia adaptation in clinical improvement.

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Coagulative changes at the height of serum disease were investigated in 28 patients with severe diphtheria. It was found that on day 10 after first injection of diphtheria antitoxin hemocoagulation underwent activation with prevailing thrombogenesis coinciding in time with acute period of serum disease. The severity of serum complications correlated with the degree of coagulation activity.

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21 seroconversion HIV-infected subjects have been examined. 16 of them presented with acute symptoms. The disease in the period of seroconversion manifested with fever, weakness, headache, pain in the throat, enlargement of peripheral lymph nodes, polymorphous eruption.

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Aspartate transaminase activity (AST) was measured in the serum of children and adults suffering from generalized meningococcal infection. Activation of AST is only rarely detected in children, which is associated with higher protection from lipid peroxidation. The ratio between antioxidants and prooxidants was higher in children than in adults.

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For the period 1990-1993, HIV infection in seroconversion was diagnosed in Russia in 21 cases. Of them, 16 patients had acute symptoms. Follow-up results are available for 12 patients in seroconversion who had either typical or obscure symptoms (6 and 6 patients, respectively).

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The authors studied changes in the levels of hepatic and myocardial enzymes in 89 patients with oropharyngeal diphtheria. The forms of the disease were different: carriage of the bacteria, local oropharyngeal diphtheria, toxic and subtoxic disease. Biochemical tests were also performed in 21 patients with lacunar angina.

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