Publications by authors named "Rosina Sanchez-Sole"
Canine lymphoma represents a biologically and metabolically heterogeneous group of neoplasms that arise from malignant transformation of lymphoid cells. An accurate diagnosis is crucial because of its impact on survival. Current diagnostic methods include clinical laboratory tests and imaging, most of which are invasive and lack sensitivity and specificity.
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- Chronic lymphocytic leukemia (CLL) is the most prevalent leukemia in dogs, involving the growth of mature but non-functional lymphocytes, often in cytotoxic T cells (TCD8), which may predict better outcomes despite some debate on their prognostic significance.
- A 10-year-old mixed-breed dog showed signs of CLL, including high lymphocyte counts, anemia, and spleen enlargement; diagnosis was confirmed via blood tests and a myelogram, leading to a chemotherapy regimen that has resulted in a good response with 13 months of survival.
- The diagnosis was validated through immunophenotyping, myelography, and flow cytometry, which identified the specific T-cell markers and excluded others, confirming the type of CLL
Background: Canine multicentric lymphomas are lymphoproliferative malignancies that have increased in recent decades. The patient's treatment and prognosis are determined by the grade, histological type, and lymphoma immunophenotyping.
Aim: To investigate the paraclinical signs and survival time in canines with different lymphoma immunophenotypes.