Treatment strategy in chronic lymphocytic leukemia with symptomatic central nervous system involvement: A case report.

Key Clinical Message: This case report offers support for treatment approaches in a historically rare and very difficult to treat CLL patient population with no established guidelines.

Abstract: Central nervous system involvement of chronic lymphocytic leukemia is a rare condition. Its diagnosis is often challenging, and treatment can be difficult with a lack of established guidelines.

Testicular asymmetry in healthy adolescent boys.

Objectives: To assess the presence of testicular asymmetry and the currently used threshold values in varicocoele management in a healthy adolescent population.

Subjects And Methods: We conducted an observational cross-sectional study from April 2015 until December 2016 in which we recruited 539 adolescent boys aged 11-16 years. A clinical examination including testicular size measurement by ultrasonography was performed.