Local inhibition of microtubule dynamics by dynein is required for neuronal cargo distribution.

Abnormal axonal transport is associated with neuronal disease. We identified a role for DHC-1, the C. elegans dynein heavy chain, in maintaining neuronal cargo distribution.

Microtubule Organization Determines Axonal Transport Dynamics.

Axonal microtubule (MT) arrays are the major cytoskeleton substrate for cargo transport. How MT organization, i.e.

The unfolded protein response is required for dendrite morphogenesis.

Precise patterning of dendritic fields is essential for the formation and function of neuronal circuits. During development, dendrites acquire their morphology by exuberant branching. How neurons cope with the increased load of protein production required for this rapid growth is poorly understood.

A Handheld Electrical Impedance Myography probe for the assessment of neuromuscular disease.

Electrical Impedance Myography (EIM) is a non-invasive, painless clinical technique for the diagnosis and monitoring of a variety of neuromuscular diseases including amyotrophic lateral sclerosis and focal nerve injuries. It involves the application of a low-intensity alternating current to a muscle group and the measurement of the consequent surface voltage patterns. This paper presents a system for the rapid and accurate acquisition of data employing an interrogating signal composed of multiple tones with frequencies between 10 kHz and 4 MHz.