Publications by authors named "Roshan Pillai"
Article Synopsis
- Mutations in the X-linked gene that encodes methyl-CpG-binding protein 2 are known to cause classical Rett syndrome (RTT) primarily in girls, while some patients present a 'Rett-syndrome-like phenotype' (RTT-L) without the typical mutations.
- The study reports on eight patients diagnosed with RTT-L who have mutations in genes not directly linked to classical RTT, and analyzes their genetic data along with insights from existing research to build a comprehensive network of protein interactions involving RTT and RTT-L genes.
- Functional analysis reveals key biological processes associated with these genes, highlighting the roles of specific transcription factors and suggesting that proteins HDAC1 and CHD4 may play crucial roles in the interaction network between RTT
Selenoproteins are important for normal brain function, and decreased function of selenoproteins can lead to impaired cognitive function and neurological disorders. This review examines the possible roles of selenoproteins in Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and epilepsy. Selenium deficiency is associated with cognitive decline, and selenoproteins may be helpful in preventing neurodegeneration in AD.
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