Publications by authors named "Roshan Liyanage"
Article Synopsis
- The polysaccharide capsule of pneumococcus protects the bacteria from the host immune system and is the main target for existing vaccines; however, the effectiveness of these vaccines can be compromised by variations in the capsule structure.
- Recent research has identified a new capsule type, 20C, which differs from the previously known B subtype due to gene inactivation affecting the capsule structure.
- There is a need for advanced genetic screening and bioinformatics to monitor mutations in capsule-related genes, which could influence vaccine effectiveness and the emergence of new capsule variants.
Background: The phenotype of Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) patients is determined by the type of DMD gene variation, its location, effect on reading frame, and its size. The primary objective of this investigation was to determine the frequency and distribution of DMD gene variants (deletions/duplications) in Sri Lanka through the utilization of a combined approach involving multiplex polymerase chain reaction (mPCR) followed by Multiplex Ligation Dependent Probe Amplification (MLPA) and compare to the international literature. The current consensus is that MLPA is a labor efficient yet expensive technique for identifying deletions and duplications in the DMD gene.
View Article and Find Full Text PDFIntroduction: Documented Duchenne Muscular Dystrophy (DMD) biomarkers are confined to Caucasians and are poor indicators of cognitive difficulties and neuropsychological alterations.
Materials And Methods: This study correlates serum protein signatures with cognitive performance in DMD patients of South Asian origin. Study included 25 DMD patients aged 6-16 years.