Publications by authors named "Roshan Jalaldeen"
Article Synopsis
- Modifications to the small intestine and liver during ALS may affect drug absorption, particularly for caffeine, leading to reduced systemic and brain exposure.
- Model drugs were tested on SOD1 mice (ALS model) and wild-type mice to compare pharmacokinetics and intestinal transport mechanisms.
- Results showed that caffeine had significantly lower absorption in SOD1 mice, linked to slower gastric emptying and lower intestinal permeability, suggesting dosage adjustments for ALS patients may be necessary.
Objective: Diagnostic role of autoantibodies (AAb) as serological biomarkers has not been specifically investigated in laryngeal cancer (LC) previously. The study investigates the presence of anti-LC AAbs and their potential as a biomarker for early diagnosis of LC, to improve patient outcome.
Method: Anti-LC AAb levels were investigated in LC patients (n = 30) and healthy individuals (n = 30) by indirect enzyme-linked immunosorbent assay (ELISA).