Customized Heparinized Alginate and Collagen Hydrogels for Tunable, Local Delivery of Angiogenic Proteins.

Therapeutic protein delivery has ushered in a promising new generation of disease treatment, garnering more recognition for its clinical potential than ever. However, proteins' limited stability, extremely short average half-lives, and evidenced toxicity following systemic delivery continue to undercut their efficacy. Biomaterial-based protein delivery, however, demonstrates the potential to overcome these obstacles.

Using the Nutri-Score to visualise food reformulation in Germany: the case of breakfast cereals.

Background: The reformulation of commonly consumed foods towards less sugar, fat, and salt is an important public health strategy to improve food choices of consumers and thus address the high prevalence of overweight and obesity. Front-of-pack nutrition labels like the Nutri-Score may drive reformulation and support nutritionally favourable food choices. Breakfast cereals are of special interest in that they tend to be high in sugar and are relatively often targeted at children.

Unfavorable food consumption in children up to school entry age: results from the nationwide German KiESEL study.

Introduction: Evidence points toward the early life being crucial for preventing nutrition-related diseases. As promotion of healthier food preferences in toddlerhood and preschool age might still modulate the trajectories of disease risk, understanding diet in these age groups is necessary. The objective was to analyze food consumption and diet quality of 1-5-year-old children living in Germany in relation to age and sex.

Multisystem approach for management of OSA in Down syndrome: a case report.

Unlabelled: Obstructive sleep apnea (OSA) is common in children with Down syndrome, with reported prevalence rates as high as 69-76%. Multiple factors predispose children with Down syndrome for OSA, including craniofacial hypoplasia (maxillary and mandibular), airway abnormalities, macroglossia, generalized hypotonia, airway hypotonia, adenotonsillar hypertrophy, and obesity. Despite the fact that the pathophysiology for OSA in children with Down syndrome is multifactorial in nature, treatment methods have focused on soft tissue in the upper airway using adenotonsillectomy and/or continuous positive airway pressure therapy.

Using Detached Industrial Hemp Leaf Inoculation Assays to Screen for Varietal Susceptibility and Product Efficacy on .

In greenhouse production, grey mould caused by Pers. is one of the most widespread and damaging diseases affecting medicinal cannabis (MC). Fungicide options to control this disease are extremely limited due to the regulations surrounding fungicides and chemical residues as the product end users are medical patients, often with compromised immune systems.

Comparison of the Declared Nutrient Content of Plant-Based Meat Substitutes and Corresponding Meat Products and Sausages in Germany.

Plant-based meat substitutes (PBMS) are becoming increasingly popular due to growing concerns about health, animal welfare, and environmental issues associated with animal-based foods. The aim of this study was to compare the declared energy and nutrient contents of PBMS with corresponding meat products and sausages available on the German market. Mandatory nutrition labelling data of 424 PBMS and 1026 meat products and sausages, surveyed in 2021 and 2020, respectively, as part of the German national monitoring of packaged food were used to test for differences in energy and nutrient contents.

Which Method of Transportation Is Associated With Better Outcomes for Patients With Firearm Injuries to the Head and Neck?

Background: In firearm injuries (FI), rapid transportation is important for survival. Information regarding different methods of transportation for head and neck FI is limited.

Purpose: The purpose of the study was to measure the association between method of transportation and the need for tracheostomy and/or intensive care unit (ICU).

One Billion hiPSC-Cardiomyocytes: Upscaling Engineered Cardiac Tissues to Create High Cell Density Therapies for Clinical Translation in Heart Regeneration.

Despite the overwhelming use of cellularized therapeutics in cardiac regenerative engineering, approaches to biomanufacture engineered cardiac tissues (ECTs) at clinical scale remain limited. This study aims to evaluate the impact of critical biomanufacturing decisions-namely cell dose, hydrogel composition, and size-on ECT formation and function-through the lens of clinical translation. ECTs were fabricated by mixing human induced pluripotent stem-cell-derived cardiomyocytes (hiPSC-CMs) and human cardiac fibroblasts into a collagen hydrogel to engineer meso-(3 × 9 mm), macro- (8 × 12 mm), and mega-ECTs (65 × 75 mm).

Outcomes of Early Versus Late Tracheostomy in Patients With COVID-19: A Multinational Cohort Study.

Unlabelled: Timing of tracheostomy in patients with COVID-19 has attracted substantial attention. Initial guidelines recommended delaying or avoiding tracheostomy due to the potential for particle aerosolization and theoretical risk to providers. However, early tracheostomy could improve patient outcomes and alleviate resource shortages.

Changing Dynamics of Accreditation in Oral and Maxillofacial Surgery.

The Commission on Dental Accreditation is responsible for accrediting postgraduate dental education programs, including residencies and fellowships using a well-delineated process that includes an annual survey of various aspects of the program related to the Standards for Advanced Dental Education Programs in Oral and Maxillofacial Surgery and a program self-study and site visit with a review by the Specialty Education Review Committee of the Commission and the Commission on a 5-year cycle. The primary goal of the accreditation process is to assure the public, the profession, and the institution that the program is in compliance with the published standards.

Management of MACROGLOSSIA: Case Series and Suggested Algorithm.

Purpose: Idiopathic macroglossia is a rare entity of true tongue enlargement without an underlying etiology. There are only a few case reports on the diagnosis and management of idiopathic macroglossia. This study's purpose was to present a series of patients with idiopathic macroglossia and suggest a treatment algorithm.

Tracheostomies of Patients With COVID-19: A Survey of Infection Reported by Health Care Professionals.

Background: Health care professionals (HCPs) performing tracheostomies in patients with COVID-19 may be at increased risk of infection.

Objective: To evaluate factors underlying HCPs' COVID-19 infection and determine whether tracheostomy providers report increased rates of infection.

Methods: An anonymous international survey examining factors associated with COVID-19 infection was made available November 2020 through July 2021 to HCPs at a convenience sample of hospitals, universities, and professional organizations.

What do dental students expect from oral and maxillofacial surgery externships?

Introduction: Limited information exists on the goals and expectations of dental students from oral and maxillofacial surgery (OMS) externships. This information is valuable to OMS residency programs. Dental students use externships to gain insight into various OMS residency programs.

Single-Ion Dual-Ion Conducting Electrolytes: The Relevance of Concentration Polarization in Solid-State Batteries.

Lithium batteries with solid polymer electrolytes (SPEs) and ions are prone to mass transport limitations, that is, concentration polarization, creating a concentration gradient with Li-ion (and counter-anion) depletion toward the respective electrode, as can be electrochemically observed in, for example, symmetric Li||Li cells and confirmed by Sand and diffusion equations. The effect of anions is systematically investigated in this work. Therefore, network-based SPEs are synthesized with either mobile (dual-ion conduction) or immobile anions (single-ion conduction) and proved solvation tests and nuclear magnetic resonance spectroscopy.

Comprehensive analysis of patients with failure of mandibular hardware.

Objective: The purpose of the study was to characterize patients who had failure of mandibular hardware (FMH).

Study Design: This retrospective cohort study consisted of patients with mandible fractures (MFs) that required surgical intervention from 2012 to 2020. Patients were included when mandibular hardware failed.

Evaluating Nurse Data Navigation Training Program: A Quality Improvement Project.

Nursing ability to navigate data by sourcing, visualizing, and managing data provides for skill and insights development. Effectiveness of clinical, operational and strategic decision making is underpinned by sound understanding of the data. The object of this quality improvement project is to design, deliver and evaluate a nursing specific training program using spreadsheet software Excel to improve nurse competence and confidence in data navigation.

Academic Global Surgery Curricula: Current Status and a Call for a More Equitable Approach.

Introduction: We aimed to search the literature for global surgical curricula, assess if published resources align with existing competency frameworks in global health and surgical education, and determine if there is consensus around a fundamental set of competencies for the developing field of academic global surgery.

Methods: We reviewed SciVerse SCOPUS, PubMed, African Medicus Index, African Journals Online (AJOL), SciELO, Latin American and Caribbean Health Sciences Literature (LILACS) and Bioline for manuscripts on global surgery curricula and evaluated the results using existing competency frameworks in global health and surgical education from Consortium of the Universities for Global Health (CUGH) and Accreditation Council for Graduate Medical Education (ACGME) professional competencies.

Results: Our search generated 250 publications, of which 18 were eligible: (1) a total of 10 reported existing competency-based curricula that were concurrent with international experiences, (2) two reported existing pre-departure competency-based curricula, (3) six proposed theoretical competency-based curricula for future global surgery education.

Frequency of Firearm Injuries to Head and Neck Increased During Covid-19 Pandemic.

Purpose: During coronavirus disease-19 (COVID-19) pandemic, hospitals faced challenges which were different than previous years. The purpose this study was to report frequency of firearm injuries (FI) to head and neck during the COVID-19 pandemic.

Materials And Methods: This cross-sectional study reviewed patients in the Trauma Registry at Grady Memorial Hospital (GMH) in Atlanta, GA.

Management of pediatric facial fractures during COVID-19 pandemic.

Objective: The coronavirus disease 2019 (COVID-19) pandemic caused delays in medical and surgical interventions in most health care systems worldwide. Oral and maxillofacial surgeons (OMSs) delayed operations to protect themselves, patients, and staff. This article (1) presents one institution's experience in the management of pediatric craniomaxillofacial trauma during the COVID-19 pandemic and (2) suggests recommendations to decrease transmission.

A cross-sectional survey of anxiety levels of oral and maxillofacial surgery residents during the early COVID-19 pandemic.

Purpose: The coronavirus disease 2019 (COVID-19) pandemic has increased anxiety among the general population. The purpose of this project was to investigate attitudes and anxiety among oral and maxillofacial surgery (OMS) residents during the early COVID-19 pandemic.

Materials And Methods: This was a cross-sectional study.

Does Burnout Exist in Academic Oral and Maxillofacial Surgery in the United States?

Introduction: Information regarding burnout in academic oral and maxillofacial surgeons (OMSs) in the United States (US) does not exist. The purpose of this project was to answer the following question: "Does burnout exist in academic OMSs in the United States?"

Materials And Methods: A 15-question anonymous survey was created based on Expanded Physician Well-Being Index (WBI, MedEd Web Solutions). The survey was sent electronically to fellows of the American Academy of Craniomaxillofacial Surgeons (AACMS) consisting of demographics, professional obligations, wellness indicators (burnout, emotional hardening, depression, anxiety, fatigue, overwhelmed), and overall quality-of-life statements.

Review of Orbital Fractures in an Urban Level I Trauma Center.

Objective: To perform a comprehensive review and analysis of surgically treated orbital fractures.

Study Design: Retrospective cohort chart review study for surgically treated orbital fractures during 5 years.

Results: A total of 173 patients (average age 41.

Phase Ib Study of Chemoprevention with Green Tea Polyphenon E and Erlotinib in Patients with Advanced Premalignant Lesions (APL) of the Head and Neck.

Purpose: On the basis of synergistic effects between green tea polyphenon E (PPE) and EGFR-tyrosine kinase inhibitor in preclinical studies, we conducted a phase Ib study of the PPE and erlotinib combination in patients with advanced premalignant lesions (APL) of the oral cavity and larynx.

Patients And Methods: Patients were treated with a fixed dose of PPE (200 mg three times a day) and dose escalation of erlotinib (50, 75, 100 mg daily) for 6 months with tissue biopsy at baseline and 6 months. Primary endpoints were safety and toxicity; secondary endpoints were evaluation of pathologic response, cancer-free survival (CFS), overall survival (OS), and biomarker modulation.