Publications by authors named "Rosengren S"
Purpose: Number magnitude is often represented spatially in the mind by a mental number line, on which small numbers are located to the left of space and large numbers to the right. As vestibular dysfunction can affect aspects of spatial cognition, we wondered whether patients with acute vestibular loss would show a directional bias along the mental number line.
Methods: We gave 18 patients with vestibular neuritis (VN) (eight left VN, ten right; mean age 54 years, range 31-75 years; four females) and 15 normal age- and education-matched controls (mean age 47 years, range 26-75 years; 11 females) a mental number bisection task.
Article Synopsis
- The ocular vestibular evoked myogenic potential (oVEMP) measures how well the otolith organs function, primarily focusing on muscle responses elicited by sound stimuli.
- The study examined the characteristics and pathways of late peaks in oVEMPs across different groups: healthy individuals, and patients with various levels of hearing and vestibular loss, using both bone and air-conducted stimuli.
- Findings revealed that in healthy subjects, the initial waves were largest and predominantly contralateral, while patients with vestibular function could still produce late peaks, suggesting they originate from a different mechanism unrelated to hearing status.
Article Synopsis
- Vestibular migraine (VM) is a prevalent cause of dizziness that can mimic other conditions like benign paroxysmal positional vertigo (BPPV) and Meniere's disease (MD), depending on the episode duration.
- The study compared symptoms and vestibular test results among 108 patients grouped by their conditions, including those experiencing short and medium-duration VM episodes.
- Findings indicated high symptom overlap among the groups, with no significant differences based on episode duration, suggesting that VM can resemble other disorders based on how long the dizziness lasts rather than distinct symptoms.
Analysis of Evusheld safety and efficacy in multiple sclerosis patients.
Mult Scler Relat Disord
August 2024
Background: In December 2021, the U.S. Food and Drug Administration issued emergency use authorization for the combination monoclonal antibodies tixagevimab and cilgavimab (Evusheld - AstraZeneca) for COVID-19 pre-exposure prophylaxis.
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- Patients with bronchiectasis experience worse health outcomes due to infections, often linked to weakened neutrophil antimicrobial responses that allow bacteria to persist.
- The study investigated the effectiveness of gremubamab, a bispecific monoclonal antibody, in boosting the ability of neutrophils to kill bacteria associated with bronchiectasis.
- Results showed that gremubamab significantly improved neutrophil functions, including opsonophagocytic killing and phagocytosis, without interfering with the body's natural antibodies, thus reducing the harmful effects of the bacterial infection.*
Objective: To examine the origin of cervical vestibular evoked myogenic potential (cVEMP) late waves (n34-p44) elicited with air-conducted click stimuli.
Design: Using a retrospective design, cVEMPs from normal volunteers were compared to those obtained from patients with vestibular and auditory pathologies.
Study Sample: (1) Normal volunteers (n = 56); (2) severe-to-profound sensorineural hearing loss (SNHL) with normal vestibular function (n = 21); (3) peripheral vestibular impairment with preserved hearing (n = 16); (4) total vestibulocochlear deficit (n = 23).
Background And Objectives: We developed repetitive ocular vestibular-evoked myogenic potentials (roVEMP) as an electrophysiologic test that allows us to elicit the characteristic decrement of extraocular muscles in patients with ocular myasthenia gravis (OMG). Case-control studies demonstrated that roVEMP reliably differentiates patients with OMG from healthy controls. We now aimed to evaluate the diagnostic accuracy of roVEMP for OMG diagnosis in patients with ptosis and/or diplopia.
View Article and Find Full Text PDFBackground: Vestibular migraine (VM) and Menière's disease (MD) are two common causes of recurrent spontaneous vertigo. Using history, video-nystagmography and audiovestibular tests, we developed machine learning models to separate these two disorders.
Methods: We recruited patients with VM or MD from a neurology outpatient facility.
Article Synopsis
- - The study highlights a novel method using microfluidic chip-based capillary zone electrophoresis-mass spectrometry (μCZE-MS) for the simultaneous measurement of ATP and its analogues in biological fluids, addressing limitations of traditional methods.
- - It successfully employed a novel ZipChip Interface to separate and identify nucleotide standards, ATP, ADP, AMP, and adenosine in plasma and BALF from rats, demonstrating quick and direct detection capabilities while emphasizing the need to protect these molecules using chelators like EDTA.
- - The μCZE-MS method is not only effective for nucleotide analysis but also shows promise for metabolite detection, suggesting its potential for advancing research on extracellular ATP in diseases and developing ATP-target
Background: Vestibular migraine (VM) is a common cause of recurrent vertigo. Migraine headache preventative therapies are currently prescribed to control vertigo symptoms in VM. Clinical trials of nutraceuticals for migraine headache prevention have shown positive outcomes, but, to date, there have been no studies to assess their effectiveness in the management of VM.
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- The study aimed to analyze nystagmus and balance characteristics in patients experiencing vertigo after cochlear implantation.
- Twenty-one patients were recruited for both retrospective and prospective examinations, involving video recordings during vertigo attacks and vestibular function tests.
- Main findings included high-velocity nystagmus linked to vertigo, with a significant portion diagnosed with conditions like secondary endolymphatic hydrops and Ménière's disease, indicating potential underlying vestibular issues after cochlear implantation.
Background: Nystagmus generated during bithermal caloric test assesses the horizontal vestibulo-ocular-reflex. Any induced symptoms are considered unwanted side effects rather than diagnostic information.
Aim: We hypothesized that nystagmus slow-phase-velocity (SPV) and subjective symptoms during caloric testing would be higher in vestibular migraine (VM) patients compared with peripheral disorders such as Meniere's disease (MD) and non-vestibular dizziness (NVD).
Aims: This study aimed to study the prognostic value of myocardial oxygen consumption (MVO ) and myocardial external efficiency (MEE) from C-acetate positron emission tomography (PET) in cardiac amyloidosis (CA) patients.
Methods And Results: Forty-eight CA patients, both transthyretin (ATTR) and immunoglobulin light chain (AL) amyloidosis, and 20 controls were included. All subjects were examined with C-acetate PET and echocardiography.
Background: Acceleration and changes in acceleration (jerk) stimulate vestibular otolith afferents. Bone-conducted (BC) vibration applied to the skull accelerates the head and produces short latency reflexes termed vestibular evoked myogenic potentials (VEMPs).
Objective: To determine the magnitude, variability and symmetry in head acceleration/jerk during VEMP recordings and investigate the relationship between head acceleration/jerk and VEMP properties.
Objective: To examine the relationship between widely used otolith function tests: the Subjective Visual Horizontal (SVH) and Vestibular Evoked Myogenic Potentials (VEMP).
Methods: A retrospective analysis was performed on 301 patients who underwent SVH, ocular and cervical VEMP (oVEMP and cVEMP) tests on the same day. Correlations between the mean SVH tilt and amplitude asymmetry ratios for bone-conducted (BC) oVEMP and air-conducted (AC) cVEMP were examined.
Object: Vestibular evoked myogenic potentials (VEMPs) and the subjective visual horizontal (SVH) (or vertical [SVV]) have both been considered tests of otolith function: ocular-VEMPs (oVEMPs) utricular function, cervical VEMPs (cVEMPs) saccular function. Some studies have reported association between decreased oVEMPs and SVH, whereas others have not.
Design: A retrospective study of test results.
Background: Cardiac amyloidosis (CA) is a restrictive and infiltrative cardiomyopathy, characterized by increased biventricular filling pressures and low output. Symptoms are predominantly of right heart origin. The role of right ventricular (RV) myocardial blood flow (MBF) in CA has not been studied.
View Article and Find Full Text PDFObjective: Menière's disease (MD) is characterized by recurrent vertigo and fluctuating aural symptoms. Diagnosis is straightforward in typical presentations, but a proportion of patients present with atypical symptoms. Our aim is to profile the array of symptoms patients may initially present with and to analyze the vestibular and audiological test results of patients with a diagnosis of MD.
View Article and Find Full Text PDFObjective: To quantify the impact of cochlear implantation (CI) on all five vestibular end-organs and on subjective ratings of post-CI dizziness.
Methods: Seventy-two patients undergoing unilateral CI were recruited for the study. All participants completed pre- and post-CI three-dimensional video head-impulse tests (3D vHITs) to assess semicircular-canal (SC) function, air- and bone-conducted (AC and BC) cervical and ocular vestibular-evoked myogenic potentials (cVEMPs and oVEMPs) to assess otolith-function and the dizziness handicap inventory (DHI) to measure self-perceived disability.
Purpose Of Review: To most neurologists, assessing the patient with vertigo is an unpleasant and worrisome task. A structured history and focused examination can be complemented by carefully selected laboratory tests, to reach an early and accurate diagnosis. We provide evidence-based recommendations for vestibular test selection.
View Article and Find Full Text PDFIntroduction: Patients with vestibular disorders sometimes report cognitive difficulties, but there is no consensus about the type or degree of cognitive complaint. We therefore investigated subjective cognitive dysfunction in a well-defined sample of neuro-otology patients and used demographic factors and scores from a measure of depression, anxiety, and stress to control for potential confounding factors.
Methods: We asked 126 neuro-otology clinic outpatients whether they experienced difficulties with thinking, memory, or concentration as a result of dizziness or vertigo.
Hypothesis: We compared two means of mitigating the effect of sternocleidomastoid (SCM) contraction strength on the cervical vestibular evoked myogenic potential (cVEMP): contraction matching and amplitude normalization.
Background: SCM muscle contraction strength affects the amplitude of the cVEMP which can impact measures of inter-side asymmetry and diagnostic outcomes.
Methods: In 19 normal subjects, we investigated the effect of muscle contraction variation within a cVEMP recording.
Rejecting Gargoylism: Reflections on the term and its relationship to Hurler syndrome.
Am J Med Genet C Semin Med Genet
June 2021
Just over a century ago, Dr. Gertrud Hurler described what is now commonly called Hurler syndrome. This rare inherited condition became known by terms describing its cardinal physical signs; the eponymous name was not proposed.
View Article and Find Full Text PDFBackground: The cervical vestibular evoked myogenic potential (cVEMP) can be affected by the recording parameters used to quantify the response.
Objective: We investigated the effects of electrode placement and montage on the variability and symmetry of sternocleidomastoid (SCM) contraction strength and cVEMP amplitude.
Methods: We used inter-side asymmetries in electrode placement to mimic small clinical errors in twenty normal subjects.