Social determinants of gastrointestinal malformation mortality in Brazil: a national study.

Introduction: In Brazil, approximately 5% are born with a congenital disorder, potentially fatal without surgery. This study aims to evaluate the relationship between gastrointestinal congenital malformation (GICM) mortality, health indicators, and socioeconomic factors in Brazil.

Methods: GICM admissions (Q39-Q45) between 2012 and 2019 were collected using national databases.

Evaluation of the regional distribution of the pediatric surgery workforce and surgical load in Brazil.

Objective: The purpose of this study is to examine the regional distribution of the pediatric surgery workforce and the expected local demand for pediatric surgical procedures in Brazil.

Methods: We collected data on the pediatric surgical workforce, surgical volume, Gross Domestic Product per capita, and mortality for gastrointestinal tract malformations (MGITM) across the different regions of Brazil for 2019.

Results: Data from the Federal Medical Council reported 1515 pediatric surgery registries in Brazil, corresponding to 1414 pediatric surgeons (some pediatric surgeons are registered in more than one state), or 2.

CircuitBot: Learning to survive with robotic circuit drawing.

Robots with the ability to actively acquire power from surroundings will be greatly beneficial for long-term autonomy and to survive in uncertain environments. In this work, a scenario is presented where a robot has limited energy, and the only way to survive is to access the energy from an unregulated power source. With no wires or resistors available, the robot heuristically learns to maximize the input voltage on its system while avoiding potential obstacles during the connection.

Variable Stiffness Object Recognition with a CNN-Bayes Classifier on a Soft Gripper.

Soft grippers significantly widen the palpation capabilities of robots, ranging from soft to hard materials without the assistance of cameras. From a medical perspective, the detection of size and shape of hard inclusions concealed within soft three-dimensional (3D) objects is meaningful for the early detection of cancer through palpation. This article proposes a framework for variable-stiffness object recognition using tactile information collected by force sensitive resistors on a three-finger soft gripper.

Bootstrapping Virtual Bipedal Walkers with Robotics Scaffolded Learning.

We reach walking optimality from a very early age by using natural supports, which can be the hands of our parents, chairs, and training wheels, and bootstrap a new knowledge from the recently acquired one. The idea behind bootstrapping is to use the previously acquired knowledge from simpler tasks to accelerate the learning of more complicated ones. In this paper, we propose a scaffolded learning method from an evolutionary perspective, where a biped creature achieves stable and independent bipedal walking while exploiting the natural scaffold of its changing morphology to create a third limb.

Simulating the evolution of bipedalism and the absence of static bipedal hexapods.

In nature, very few animals locomote on two legs. Static bipedalism can be found in four limbed and five limbed animals like dogs, cats, birds, monkeys and kangaroos, but it cannot be seen in hexapods or other multi-limbed animals. In this paper, we present a simulation with a novel perspective on the evolution of static bipedalism, with a virtual creature evolving its body and controllers, and we apply an evolutionary algorithm to explore the locomotion transition from octapods to bipods.

Risk-Aware Model-Based Control.

Model-Based Reinforcement Learning (MBRL) algorithms have been shown to have an advantage on data-efficiency, but often overshadowed by state-of-the-art model-free methods in performance, especially when facing high-dimensional and complex problems. In this work, a novel MBRL method is proposed, called Risk-Aware Model-Based Control (RAMCO). It combines uncertainty-aware deep dynamics models and the risk assessment technique Conditional Value at Risk (CVaR).

Robotic investigation on effect of stretch reflex and crossed inhibitory response on bipedal hopping.

To maintain balance during dynamic locomotion, the effects of proprioceptive sensory feedback control (e.g. reflexive control) should not be ignored because of its simple sensation and fast reaction time.

The trade-off between morphology and control in the co-optimized design of robots.

Conventionally, robot morphologies are developed through simulations and calculations, and different control methods are applied afterwards. Assuming that simulations and predictions are simplified representations of our reality, how sure can roboticists be that the chosen morphology is the most adequate for the possible control choices in the real-world? Here we study the influence of the design parameters in the creation of a robot with a Bayesian morphology-control (MC) co-optimization process. A robot autonomously creates child robots from a set of possible design parameters and uses Bayesian Optimization (BO) to infer the best locomotion behavior from real world experiments.

Dasatinib Reversibly Disrupts Endothelial Vascular Integrity by Increasing Non-Muscle Myosin II Contractility in a ROCK-Dependent Manner.

Dasatinib is a short-acting dual ABL/SRC family tyrosine kinase inhibitor (TKI), which is frequently used to treat chronic myeloid leukemia. Although very effective, patients taking dasatinib often display severe adverse effects, including pleural effusions and increased risk of bleeding primarily in the gastrointestinal tract. The actual causes of these side effects are currently undetermined.

Prosthetic design directives: Low-cost hands within reach.

Although three million people around the world suffer from the lack of one or both upper limbs 80% of this number is located within developing countries. While prosthetic prices soar with technology 3D printing and low cost electronics present a sensible solution for those that cannot afford expensive prosthetics. The electronic and control design of a low-cost prosthetic hand, the Touch Hand II, is discussed.

Embroidered archimedean spiral electrodes for contactless prosthetic control.

With continuous advancements on active prosthetics the detection of the user's intention becomes the new technological bottleneck. While electromyography (EMG) is widely used to detect individual muscular contributions, sweat and relative sensor movements degrade the quality of the signal over time. In this paper, we bypass the problems created with the skin contact analyzing the muscular activation with Archimedean Spiral (AS) electrodes.

Evolutionary Developmental Robotics: Improving Morphology and Control of Physical Robots.

Evolutionary algorithms have previously been applied to the design of morphology and control of robots. The design space for such tasks can be very complex, which can prevent evolution from efficiently discovering fit solutions. In this article we introduce an evolutionary-developmental (evo-devo) experiment with real-world robots.

Energy efficient hopping with Hill-type muscle properties on segmented legs.

The intrinsic muscular properties of biological muscles are the main source of stabilization during locomotion, and superior biological performance is obtained with low energy costs. Man-made actuators struggle to reach the same energy efficiency seen in biological muscles. Here, we compare muscle properties within a one-dimensional and a two-segmented hopping leg.

Stretch reflex improves rolling stability during hopping of a decerebrate biped system.

When humans hop, attitude recovery can be observed in both the sagittal and frontal planes. While it is agreed that the brain plays an important role in leg placement, the role of low-level feedback (the stretch reflex) on frontal plane stabilization remains unclear. Seeking to better understand the contribution of the soleus stretch reflex to rolling stability, we performed experiments on a biomimetic humanoid hopping robot.

Self-injurious behavior in Portuguese adolescents.

In order to assess the frequency and correlates of self-injurious behavior (SIB), 569 Portuguese adolescents aged 12 to 20 years completed questionnaires assessing SIB and psychopathological symptoms. Almost 28% (n = 158) reported a lifetime history of SIB and nearly 10% had performed it in the previous month. The most frequently injured body parts were arms, hands and nails.

Microsatellite mapping of quantitative trait loci affecting female reproductive tract characteristics in Meishan x Large White F(2) pigs.

A QTL analysis of female reproductive data from a 3-generation experimental cross between Meishan and Large White pig breeds is presented. Six F(1) boars and 23 F(1) sows, progeny of 6 Large White boars and 6 Meishan sows, produced 502 F(2) gilts whose reproductive tract was collected after slaughter at 30 d of gestation. Five traits [i.

Lipid and C-reactive protein levels, cardiovascular disease risk factors and simvastatin treatment in Brazilian individuals.

Background: The Framingham Risk Score (FRS) is widely recommended to estimate global risk for cardiovascular (CV) disease; however, it does not recognize all individuals with a high risk for coronary artery disease, because it does not take into account the various novel markers, such as the C-reactive protein levels (CRP). The present study aims to describe the profile of the simvastatin users and non-users in relation to FRS and high-sensitivity CRP (hs-CRP) levels.

Methods: In this cross-sectional study, 277 European descent individuals were divided in two groups: 177 using simvastatin 20 mg per day (T+) and 100 not using simvastatin (T-).

Correlative responses for carcass and meat quality traits to selection for ovulation rate or prenatal survival in French Large White pigs.

Correlated effects of selection for components of litter size on carcass and meat quality traits were estimated using data from 3 lines of pigs derived from the same Large White base population. Two lines were selected for 6 generations on high ovulation rate at puberty (OR) or high prenatal survival corrected for ovulation rate in the first 2 parities (PS). The third line was an unselected control (CON).

Detection of quantitative trait loci for teat number and female reproductive traits in Meishan × Large White F2 pigs.

A quantitative trait locus (QTL) analysis of female reproductive data from a three-generation experimental cross between Meishan (MS) and Large White (LW) pig breeds is presented. Six F1 boars and 23 F1 sows, progeny of six LW boars and six MS sows, produced 573 F2 females and 530 F2 males. Six traits, i.

[Pharmacogenetics and anti-inflammatory effect of HMG-CoA reductase inhibitors].

Atherosclerosis is a result from the association of lipid deposition in the arterial wall and inflammatory process. This inflammatory process may be detected by clinical markers of systemic inflammation, such as ultrasensible C-reactive protein, which is associated with cardiovascular risk, independently of lipid levels. Statins reduce the inflammation associated to atherosclerosis, which may be verified by a reduction of the C-reactive protein levels.

Correlated responses of pre- and postweaning growth and backfat thickness to six generations of selection for ovulation rate or prenatal survival in French Large White pigs.

Correlated effects of selection for components of litter size on growth and backfat thickness were estimated using data from 3 pig lines derived from the same base population of Large White. Two lines were selected for 6 generations on either high ovulation rate at puberty (OR) or high prenatal survival corrected for ovulation rate in the first 2 parities (PS). The third line was an unselected control (C).

Correlated responses for litter traits to six generations of selection for ovulation rate or prenatal survival in French Large White pigs.

Effects of selection for reproductive traits were estimated using data from 3 pig lines derived from the same Large White population base. Two lines were selected for 6 generations on high ovulation rate at puberty (OR line) or high prenatal survival corrected for ovulation rate in the first 2 parities (PS line). The third line was an unselected control line.

Direct responses to six generations of selection for ovulation rate or prenatal survival in Large White pigs.

Effects of selection for ovulation rate or prenatal survival were examined using data from 3 pigs lines derived from the same base Large White population. Two lines were selected for 6 generations on high ovulation rate at puberty (OR line) or high prenatal survival corrected for ovulation rate in the first 2 parities (PS line). The third line was an unselected control line.