Integral differences among human survival distributions as a function of disease.

The mortality kinetics of white humans of the United States were examined for 25 different age-related causes of death (22 male, 21 female). The survivorship distributions for these diseases clustered into groups, as defined by their position on the time axis. When the survivorship curves were linearized, by plotting as log(-log S(t] vs.

Preliminary studies of a new stochastic human death function involving small integers.

We propose a new mathematical function for the analyses of age-related human deaths due to single causes. Like the earlier Gompertz and power law functions, it is a two parameter function. Unlike them, one of the parameters is an integer in the range of 5-13.

Predictors of recurrence and survival of patients with breast cancer.

In this study, the characteristics of 646 patient's primary breast carcinomas, including histologic grade (HG), nuclear grade (NG), mitotic grade (MG), final grade (FG), estrogen receptor (E2R) status, and patient's lymph node status (LN) at the time of surgery were correlated with recurrence-free interval and patient survival in order to determine whether any one parameter or group of parameters serve as adequate predictors of tumor behavior and, therefore, patient's prognosis. The authors' results showed that LN, tumor size, and tumor grade were themselves significant predictors of early recurrence and breast cancer death. Each unit increase in LN or MG increased the risk of death by a factor of 1.

Is there eye-position-dependent facilitation of memory?

It was hypothesized that if eye-position-dependent facilitation of information retrieval underlies the phenomenon of lateral eye movements (LEMs), then subjects whose visual fixation points were assigned during both encoding and retrieval would have better recall when the points for encoding and retrieval were the same than when they were different. Sixty student volunteers gazed either straight ahead, 20 degrees right, 40 degrees right, 20 degrees left, or 40 degrees left while encoding and retrieving verbally presented word pairs. Response latency, as measured by stopwatch from audio recordings, was significantly greater for difficult word pairs when encoding and retrieval points were different, (t = 1.

Duodenal gangliocytic paragangliomas: a study of 10 cases with immunocytochemical neuroendocrine markers.

Ten cases of duodenal paraganglioma were studied by conventional histologic and immunocytochemical techniques at both light and electron microscopic levels. Histologically, mixtures of epithelial, ganglion, and spindle cells were seen. In all of the cases immunoreactivity for neuron-specific enolase (NSE) and protein gene product (PGP) 9.

Minimal renal amyloidosis with nephrotic syndrome.

Two patients older than age 50 years had minimal amyloidosis in association with the nephrotic syndrome. The amyloid deposits in each case were so inconspicuous as to have been initially overlooked, and both biopsy specimens were thought to show minimal glomerular changes. A few, widely scattered, silver-positive, epimembranous spicules were found on reexamination by light microscopy, and Congo red and thioflavin T stains and electron microscopy confirmed the presence of small glomerular amyloid deposits.

Further observations in the ultrasound evaluation of renal allograft rejection.

In order to determine whether sonographic parenchymal changes and volume changes are reliable predictors of acute transplant rejection, 36 recipients of renal allografts were studied. The significance of graft volume changes was evaluated, since most previous studies have not utilized routine immediate postoperative baseline scans for comparison to follow-up scans. All patients had baseline scans within 24 hours of the transplant.

Inhibition of SV40 DNA replication by benzo[a]pyrene diol epoxide adducts: two recovery modes.

Anti-benzo[a]pyrene diol epoxide (BPDE) adducts produced in vitro in SV40 initially inhibit SV40 DNA replication in vivo, in cells unexposed to BPDE. A single adduct in a replicon is probably sufficient to block DNA replication. The recovery process appears to begin immediately after infection.

Epidural morphine: a new approach to combined anesthesia and analgesia in urological patients.

The effect of combined epidural anesthesia and epidural morphine injection is discussed. A group of 98 patients (group A), chosen at random, was operated on under such combined anesthesia and compared to a similar group of 98 patients (group B), equally chosen at random, operated on under either spinal or general anesthesia with no epidural morphine added. Over 87% of group A needed no narcotic drugs for postoperative pain.

A radioreceptor assay in which iodocyanopindolol is used to determine propranolol and its active metabolites in unextracted serum or plasma.

This rapid, sensitive, simple radioreceptor assay (RRA) for l-propranolol and its active metabolites in unextracted samples requires 5 microL of sample, a beta-adrenergic antagonist, 125-l-labeled (-)cyanopindolol (125ICYP), and turkey erythrocyte membrane receptors (Kd = 40 pmol/L). Equal volumes (100 microL) of diluted sample and 125ICYP are incubated with 500 microL of erythrocyte membranes for 30 min. Cold isotonic saline (2.

Grammatical class effects in relation to normal and aphasic sentence processing.

Agrammatic, Broca's aphasic patients, Wernicke's aphasic patients, and neurologically intact control subjects were asked to detect target letters in prose passages and in a scrambled word passage. The targets were embedded, in some instances, in content words (open-class vocabulary items), and in other instances, in function words (closed-class vocabulary items). With respect to the prose passages, both the control subjects and Wernicke's aphasic patients were more apt to notice target letters when they appeared in the open-class items than when in closed-class items; by contrast, the agrammatic Broca's patients showed no vocabulary class detection difference.

Immunotactoid glomerulopathy.

We present 11 patients with immunotactoid glomerulopathy, a new syndrome characterized clinically by proteinuria (11/11), microscopic hematuria (9/11) and hypertension (9/11). The patients consisted of six females and five males, aged 25 to 59 years (mean, 44.6).

Verrucous carcinoma: a possible viral pathogenesis.

Seventeen cases of verrucous carcinoma of the oral cavity were reviewed. It was found that cytologic features generally associated with viral modification were observed in 15 of these cases. This finding suggests that viruses may play some role in the pathogenesis of verrucous carcinoma.

[Eisenmenger's syndrome in pregnancy. Controlled segmental epidural block for cesarean section].

We present a case of Eisenmenger's Syndrome in which an elective Caesarean Section was carried out successfully under lumbar epidural anaesthesia, following adequate physiological and psychological preparation of the patient.

Interaction of estrogen receptor of calf uterus with a monoclonal antibody: probing of various molecular forms.

A monoclonal antibody to estrogen receptor (JS34/32) is able to recognize, in the calf uterine cytosol, a protein (approximately 65 000 daltons) giving a single band on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Two molecules of this antibody are able to simultaneously interact with the native 8S form of the receptor present in the calf uterine cytosol ("twin antibody" assay). This indicates the presence of two antigenic determinants on the "low-salt" 8S form of the receptor.

Histochemical changes of the developing human cerebral neocortex. Studies on two enzymes of energy metabolism in three cortical areas.

Developmental changes of two mitochondrial enzymes, succinate- and menadione-dependent alpha-glycerophosphate dehydrogenases (SDH, M alpha GPDH) have been studied by histochemical techniques in early autopsy material in the following areas of human neocortex: area 4 (motor cortex), area 17 (visual cortex) and area 40 (associative cortex). Each area studied revealed a special enzymatic architecture. SDH - a marker of oxidative activity - develops for several years after birth and in some areas (4 and 40) reaches its adult pattern only after 11 years.