A Thematic Analysis of Couples' Sexual Well-Being Following a Recent Pregnancy Loss.

Pregnancy loss has been linked to poorer mental and relationship well-being. Given that strong sexual well-being is associated with better mental and physical health, understanding sexual well-being following a recent pregnancy loss may contribute to education and treatment models. Yet, little research has examined the effects of pregnancy loss on both couple members' sexual well-being.

Sexual satisfaction mediates daily associations between body satisfaction and relationship satisfaction in new parent couples.

One of the most common reported postpartum concerns, linked with relationship dissatisfaction, is how body image will affect sexuality. Outside of the postpartum period, feeling more satisfied with one's body is linked with feeling more sexually and relationally satisfied, with some cross-sectional evidence that sexual satisfaction mediates these associations. This dyadic daily experience study examined how new parents' daily satisfaction with their own and their partner's bodies relates to their own sexual satisfaction, and in turn, their own and their partner's relationship satisfaction during a vulnerable time in their sexual and romantic relationship-3- to 4-months postpartum.

Description, Implementation, and Efficacy of the Comprehensive Behavioral Intervention for Tics as First-Line Treatment for Tourette and Other Tic Disorders.

To provide an evidence-based review of the Comprehensive Behavioral Intervention for Tic (CBIT) disorders. For close to a century, behavioral interventions for managing tics associated with Tourette and other tic disorders (TDs) were incorrectly considered ineffective and dangerous by the professional community, due, in large part, to unfounded fears that efforts to suppress tics would lead to a host of negative psychological, and even physical, outcomes (e.g.

Trajectories of sexual well-being and links with grief after a recent pregnancy loss: a dyadic longitudinal study.

Background: Pregnancy loss affects 1 in 4 women and is linked with poorer overall health and relationship outcomes. Despite sexual well-being's importance to health, how sexual well-being changes across time after a pregnancy loss and what might predict such changes, like perinatal grief, have never been examined, leaving practitioners and couples without knowledge of what to expect.

Aim: We aimed to examine (1) how sexual satisfaction, sexual desire, sexual distress, and perinatal grief change from 10 to 25 weeks postloss for both couple members; and (2) if perinatal grief levels at 10 weeks postloss predict sexual well-being trajectories.

Attraction Toward One's Partner is Associated with Sexual Desire, Satisfaction, and Distress Among Couples Coping with Sexual Interest/Arousal Disorder.

The sexual incentive motivation model suggests that attractive stimuli activate the sexual response system. Attraction toward one's partner has been linked to greater sexual satisfaction, but no quantitative studies have examined its links to sexual desire or distress among those with sexual dysfunction. We examined associations between daily attraction toward one's partner and sexual satisfaction, desire, and distress for individuals with Sexual Interest/Arousal Disorder (SIAD) and their partners.

Interpersonal emotion regulation during relationship conflict: Daily and longitudinal associations with couples' sexual well-being.

Relationship conflicts, which are common among committed couples, provoke negative emotions with implications for sexual well-being (i.e., satisfaction, desire, low distress).

Connecting through touch: Attitudes toward touch in pregnancy are associated with couples' sexual and affectionate behaviors across the transition to parenthood.

Touch is a universal nonverbal action often used by romantic partners to demonstrate affection and care for each other. Attitudes toward touch might be particularly relevant across periods of relational strain-such as the transition to parenthood-when couples face many novel stressors and shifting priorities which can interfere with their sexual and affectionate experiences. New parent couples ( = 203) completed self-report measures online across six time-points (two prenatal).

Do Demand-Withdrawal Communication Patterns During Sexual Conflict Predict Couples' Relationship Satisfaction, Sexual Satisfaction, and Sexual Distress? An Observational and Prospective Study.

Sexual conflict is common, yet it is one of the most challenging topics for couples because it provokes more negative emotions relative to other conflicts. Such challenges might prompt couples to rely on less adaptive sexual communication styles. Communication patterns during sexual conflict - such as demand-withdrawal - have received little attention, and studies that do exist relied on self-report measures.

Combined inhibition of KRAS and mTORC1 kinase is synergistic in non-small cell lung cancer.

Current KRAS (OFF) inhibitors that target inactive GDP-bound KRAS cause responses in less than half of patients and these responses are not durable. A class of RAS (ON) inhibitors that targets active GTP-bound KRAS blocks ERK signaling more potently than the inactive-state inhibitors. Sensitivity to either class of agents is strongly correlated with inhibition of mTORC1 activity.

Diet induced insulin resistance is due to induction of PTEN expression.

Type 2 Diabetes (T2D) is a condition that is often associated with obesity and defined by reduced sensitivity of PI3K signaling to insulin (insulin resistance), hyperinsulinemia and hyperglycemia. Molecular causes and early signaling events underlying insulin resistance are not well understood. Insulin activation of PI3K signaling causes mTOR dependent induction of PTEN translation, a negative regulator of PI3K signaling.

Tumor-Agnostic Genomic and Clinical Analysis of BRAF Fusions Identifies Actionable Targets.

Purpose: Even though BRAF fusions are increasingly detected in standard multigene next-generation sequencing panels, few reports have explored their structure and impact on clinical course.

Experimental Design: We collected data from patients with BRAF fusion-positive cancers identified through a genotyping protocol of 97,024 samples. Fusions were characterized and reviewed for oncogenic potential (in-frame status, non-BRAF partner gene, and intact BRAF kinase domain).

Intermittent MEK Inhibition with GITR Costimulation Rescues T-cell Function for Increased Efficacy with CTLA-4 Blockade in Solid Tumor Models.

MEK inhibitors (MEKi) have shown limited success as a treatment for MAPK/ERK pathway-dependent cancers due to various resistance mechanisms tumor cells can employ. CH5126766 (CKI27) is an inhibitor that binds to MEK and prevents release of RAF, reducing the relief of negative feedback commonly observed with other MEKis. We observed that CKI27 increased MHC expression in tumor cells and improved T cell-mediated killing.

Intimacy Promotes Couples' Sexual Well-Being on a Daily Basis and Over One Year: The Role of Positive Sexual Cues.

There is growing interest in identifying factors that promote sexual well-being in romantic relationships. One such factor is intimacy-a process involving self-disclosure and empathic response that is positively associated with sexuality outcomes. However, most work among community couples examined cross-sectional associations in mixed-sex/gender couples using a single sexual outcome, which may not capture daily variations in intimacy and different dimensions of sexual well-being among a diversity of unions over time.

Under Pressure: Men's and Women's Sexual Performance Anxiety in the Sexual Interactions of Adult Couples.

Most research on sexual performance anxiety has focused on men's experiences and links to erectile functioning and premature ejaculation, with little research attention given to women's experiences or to relationship dynamics. At times, sexual performance anxiety has been examined in the context of dysfunction, but rarely as a focus in its own right. Study 1 asked 51 participants reporting sexual performance anxiety to describe the cognitive and affective components of their experiences, coping strategies, and perceived impact on their relationship using open-ended responses from online surveys.

eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer.

The majority of human breast cancers are dependent on hormone-stimulated estrogen receptor alpha (ER) and are sensitive to its inhibition. Treatment resistance arises in most advanced cancers due to genetic alterations that promote ligand independent activation of ER itself or ER target genes. Whereas re-targeting of the ER ligand binding domain (LBD) with newer ER antagonists can work in some cases, these drugs are largely ineffective in many genetic backgrounds including ER fusions that lose the LBD or in cancers that hyperactivate ER targets.

Tumorigenesis driven by the BRAF oncoprotein requires secondary mutations that overcome its feedback inhibition of migration and invasion.

mutation occurs in 46% of melanomas and drives high levels of ERK activity and ERK-dependent proliferation. However, is insufficient to drive melanoma in GEMM models, and 82% of human benign nevi harbor mutations. We show here that BRAF inhibits mesenchymal migration by causing feedback inhibition of RAC1 activity.

A Proposed Mechanism for Visual Vertigo: Post-Concussion Patients Have Higher Gain From Visual Input Into Subcortical Gaze Stabilization.

Purpose: Post-concussion syndrome (PCS) is commonly associated with dizziness and visual motion sensitivity. This case-control study set out to explore altered motion processing in PCS by measuring gaze stabilization as a reflection of the capacity of the brain to integrate motion, and it aimed to uncover mechanisms of injury where invasive subcortical recordings are not feasible.

Methods: A total of 554 eye movements were analyzed in 10 PCS patients and nine healthy controls across 171 trials.

Feasibility of a Cognitive-Behavioral Couple Therapy Intervention for Sexual Interest/Arousal Disorder.

Female sexual interest/arousal disorder (SIAD) is strongly influenced by interpersonal factors; however, there are no empirically-supported, couple-based sex therapy interventions for this disorder. This pre-registered study tested the feasibility of a cognitive-behavioral couple therapy (CBCT) intervention for SIAD. A sample of 19 couples in which a female partner was diagnosed with SIAD completed a 16-session CBCT intervention delivered online by therapists with PhD-level training in clinical psychology.

Effectiveness and Safety of a New Hyaluronic Acid Injectable for Augmentation and Correction of Chin Retrusion.

Background: A hyaluronic acid (HA) filler intended for non-surgical improvement of chin appearance should ideally be of high strength/firmness (high G') to allow for deep injections on the bone. HASHA (Restylane Shaype) is a new hyaluronic acid (HA) injectable with high G' and high HA concentration (25 mg/mL), engineered by the new NASHA-HD (High Definition) technology. HASHA is suitable to be placed periosteally, aiming to mimic the natural shape of the bony chin.