Publications by authors named "Rosemeire Aparecida-Silva"

Chagas disease (CD), caused by the hemoflagellate protozoan , affects more than six million people worldwide and presents an unsatisfactory therapy, based on two nitroderivatives, introduced in clinical medicine for decades. The synthetic peptide, with CTHRSSVVC sequence (PepA), mimics the CD163 and TNF-α tripeptide "RSS" motif and binds to atheromatous plaques in carotid biopsies of human patients, spleen tissues, and a low-density lipoprotein receptor knockout (LDLr-/-) mouse model of atherosclerosis. CD163 receptor is present on monocytes, macrophages, and neutrophils, acting as a regulator of acute-phase processes and modulating aspects of the inflammatory response and the establishment of infections.

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In ascending aorta aneurysms and dissections, the extracellular matrix is degraded. Transforming growth factor (TGF)-β1 modulates its synthesis. The production and presence of SMADs, intracellular effectors of TGF-β1 signaling, were analyzed in patients with these diseases.

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