Publications by authors named "Rosemary Scott"
Objectives: To compare the diagnostic yield of whole-body post-mortem computed tomography (PMCT) imaging to post-mortem magnetic resonance (PMMR) imaging in a prospective study of fetuses and children.
Methods: We compared PMCT and PMMR to conventional autopsy as the gold standard for the detection of (a) major pathological abnormalities related to the cause of death and (b) all diagnostic findings in five different body organ systems.
Results: Eighty two cases (53 fetuses and 29 children) underwent PMCT and PMMR prior to autopsy, at which 55 major abnormalities were identified.
Article Synopsis
- A study was conducted to assess how effective post-mortem magnetic resonance imaging (PMMR) is for identifying abdominal issues in foetuses and children compared to traditional autopsy.
- Out of 400 cases examined, PMMR showed a sensitivity of 72.5% and specificity of 90.8% for abdominal pathologies, with better detection of renal abnormalities (80% sensitivity) and less success for intestinal issues (50% sensitivity).
- The research concluded that PMMR has high accuracy in detecting abdominal problems in young patients and could serve as a beneficial alternative or supplement to conventional autopsy methods.
Objectives: To compare the diagnostic accuracy of post-mortem magnetic resonance imaging (PMMR) specifically for non-cardiac thoracic pathology in fetuses and children, compared with conventional autopsy.
Methods: Institutional ethics approval and parental consent was obtained. A total of 400 unselected fetuses and children underwent PMMR before conventional autopsy, reported blinded to the other dataset.
Objectives: The aim of this study was to compare the diagnostic accuracy of postmortem magnetic resonance (PMMR) imaging specifically for musculoskeletal pathology in fetuses and children, compared with conventional autopsy, with radiographic and histopathology assessment.
Methods: Institutional ethics approval and parental consent was obtained. A total of 400 cases underwent PMMR using a 1.
Pregnancy can precipitate thrombotic thrombocytopenic purpura (TTP). We present a prospective study of TTP cases from the United Kingdom Thrombotic Thrombocytopenic Purpura (UK TTP) Registry with clinical and laboratory data from the largest cohort of pregnancy-associated TTP and describe management through pregnancy, averting fetal loss and maternal complications. Thirty-five women presented with a first TTP episode during pregnancy: 23/47 with their first congenital TTP (cTTP) episode and 12/47 with acute acquired TTP in pregnancy.
View Article and Find Full Text PDFBackground: Perinatal and pediatric autopsies have declined worldwide in the past decade. We compared the diagnostic accuracy of postmortem, cardiovascular magnetic resonance (CMR) imaging with conventional autopsy and histopathology assessment in fetuses and children.
Methods And Results: We performed postmortem magnetic resonance imaging in 400 fetuses and children, using a 1.
Background: Post-mortem MRI is a potential diagnostic alternative to conventional autopsy, but few large prospective studies have compared its accuracy with that of conventional autopsy. We assessed the accuracy of whole-body, post-mortem MRI for detection of major pathological lesions associated with death in a prospective cohort of fetuses and children.
Methods: In this prospective validation study, we did pre-autopsy, post-mortem, whole-body MRI at 1·5 T in an unselected population of fetuses (≤24 weeks' or >24 weeks' gestation) and children (aged <16 years) at two UK centres in London between March 1, 2007 and Sept 30, 2011.
We report on 14 fetuses from 10 families with the autosomal recessive syndrome of proliferative vasculopathy and hydranencephaly-hydrocephaly (Fowler syndrome). In four families sibs were affected and in six the parents were consanguineous. Antenatal ultrasonography showed hydrocephaly in all except two fetuses, but hydranencephaly was diagnosed in only one case.
View Article and Find Full Text PDFThis report describes an acardiac fetus of the acormus phenotype in a triplet pregnancy. The diagnosis was confirmed at 15 weeks. In the absence of signs of heart failure in the co-fetus the pregnancy was managed conservatively.
View Article and Find Full Text PDFArticle Synopsis
- High-field MRI at 9.4 T offers significantly better image quality and tissue contrast for evaluating small human fetuses compared to conventional MRI at 1.5 T.
- A study involving 18 fetuses showed that all detected abnormalities via invasive autopsy corresponded with findings from high-field MRI, while 78% of cases were missed using conventional MRI.
- High-field MRI shows promise as a minimally invasive alternative for perinatal autopsies, effectively providing good tissue characterization even for very small fetuses.
Folic acid supplementation can prevent many cases of neural tube defects (NTDs), whereas suboptimal maternal folate status is a risk factor, suggesting that folate metabolism is a key determinant of susceptibility to NTDs. Despite extensive genetic analysis of folate cycle enzymes, and quantification of metabolites in maternal blood, neither the protective mechanism nor the relationship between maternal folate status and susceptibility are understood in most cases. In order to investigate potential abnormalities in folate metabolism in the embryo itself, we derived primary fibroblastic cell lines from foetuses affected by NTDs and subjected them to the dU suppression test, a sensitive metabolic test of folate metabolism.
View Article and Find Full Text PDFObjective: To investigate the effect of intravenous lipopolysaccharide on systemic and cerebral haemodynamics and oxygenation in the preterm ovine fetus.
Design: Prospective observational study.
Setting: Research centre for perinatal brain injury.