Publications by authors named "Rosemary Komolafe"

Article Synopsis
  • This study examined the prevalence, complications, and mortality rates of preeclampsia and eclampsia among pregnant women in Nigeria using data from various electronic databases.* -
  • The findings showed a prevalence of 4.51% for preeclampsia and 1.39% for eclampsia, with substantial maternal (6.04%) and fetal (16.73%) mortality rates linked to these conditions.* -
  • The research highlights the urgent need for improved healthcare strategies in Nigeria to address the severe impacts of these hypertensive disorders during pregnancy.*
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  • Polycystic ovary syndrome (PCOS) is a common hormonal disorder in women of reproductive age, influenced by genetics, hormones, and environmental factors.* -
  • Serum kisspeptin is highlighted as a potential biomarker for PCOS due to its role in regulating the hypothalamic-pituitary-gonadal (HPG) axis, but there are challenges in utilizing it effectively for diagnosis.* -
  • The review stresses the need for standardized research methods and further investigation into genetic variations to improve the reliability of kisspeptin as a diagnostic tool for PCOS.*
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Article Synopsis
  • * A review of studies from 2000 to February 2024 reveals that these conditions lead to significant memory and cognitive impairments in mothers and cognitive deficits in their children due to factors like placental issues and maternal stress.
  • * The research calls for a better understanding of the causes and the development of early interventions to help improve cognitive health in affected mothers and children through a multidisciplinary approach.
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  • Ovarian cancer is a leading cause of death among gynecologic cancers, and this paper investigates the use of mirvetuximab soravtansine, a targeted therapy for platinum-resistant ovarian cancer expressing folate receptor alpha (FRα).
  • Four key studies involving 453 participants show that mirvetuximab soravtansine is effective in fighting tumors with a good safety profile, particularly beneficial for tumors with high FRα expression.
  • While the treatment shows promise for enhancing therapy outcomes, further research is needed to address patient diversity, improve quality of life data, and understand long-term safety, as well as to identify more biomarkers for personalized treatment options.
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Article Synopsis
  • - Group B streptococcus (GBS) poses serious risks to newborns, prompting research into maternal vaccination as a preventative measure due to limitations of current intrapartum antibiotics.
  • - A review of five studies indicated that maternal GBS vaccines are effective and generally safe, though varying immune responses highlight the need for personalized vaccination strategies.
  • - Successful integration of GBS vaccination into maternal health programs faces challenges, particularly in resource-limited settings, necessitating efforts to address cultural barriers and improve healthcare provider knowledge.
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Breast cancer remains a significant global health challenge, necessitating innovative therapeutic strategies. This review synthesizes findings from multiple studies investigating the safety profile and efficacy of the AE37 human epidermal growth factor receptor 2 (HER2)-targeted vaccine, offering insights into its potential role in breast cancer immunotherapy. A systematic search of electronic databases, including PubMed, MEDLINE, Scopus, and Web of Science, was conducted to identify relevant articles published up to October 2023.

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To date, loop diuretics are the mainstay treatment for decongestion in patients with acute decompensated heart failure (HF). In clinical practice, loop diuretics have also been utilized for patients with chronic HF with reduced and preserved ejection fractions. There is a paucity of quality evidence of the effect of loop diuretics use and dosing on clinical outcomes in HF patients beyond symptomatic relief.

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