Neutrophil-to-lymphocyte Ratio as a Marker for Diagnosis and Prognostication of Sepsis.

Purpose: Exploring the ideal marker for early diagnosis and prognosis of sepsis is crucial due to limitations of available sepsis indicators. Hence, we aimed to evaluate the neutrophil-to-lymphocyte ratio (NLR) as a diagnostic and prognostic marker of sepsis.

Materials And Methods: This prospective case-control study was conducted at a tertiary care teaching public hospital.

Clinical Practice Guidelines for Management of Pain, Agitation, Delirium, Immobility, and Sleep Disturbance in the Intensive Care Unit: The ABCDEF Bundle.

It is crucial to prevent and manage intensive care unit (ICU) distress caused by a pentad of pain, agitation, delirium, immobility, and sleep disturbance (PADIS) to optimize immediate and longterm recovery and outcomes of critically ill patients. This clinical practice guideline provides an update on the prevention, management, and liberation of PADIS in adult ICU patients using an integrated, evidence-based, multidisciplinary ICU protocol: the ABCDEF bundle. ABCDEF bundle incorporates assessment, prevention, and management of pain; both spontaneous awakening trial (SAT) and spontaneous breathing trial (SBT); choice of sedation and analgesia; delirium: assessment, prevention and management, and early mobility and exercise; family involvement and empowerment (ABCDEF) together as a PADIS care bundle.

HEPATIC DYSFUNCTION IN MEDICAL INTENSIVE CAREUNIT PATIENTS PREDICTS POOR OUTCOME.

Background: A large number of patients admitted to the medical intensive care unit (MICU) have abnormal liver function tests (LFT). This includes patients with critical illness with or without preexisting liver disease and patients with acute primary liver injury. There are very few studies which have investigated the spectrum of liver disease, clinical profile and outcome in patients admitted to the MICU.

Assessment of Fluid Responsiveness by Changes in End Tidal Carbon Dioxide During Passive Leg Raising Test and Fluid Challenge.

Purpose: It is rationale to predict fluid responsiveness for optimum hemodynamic management. Passive Leg Raising (PLR) causes reversible increase in cardiac output (CO) and changes in end-tidal CO2& pressure (ETCO2 ) can be considered surrogate for CO variations. We aimed to assess the variations in EtCO2 with PLR and fluid challenge (FC) and also compared it with systolic arterial pressure (SAP), mean arterial pressure (MAP), heart rate (HR) and central venous pressure (CVP).

Factors associated with mortality among moderate and severe patients with COVID-19 in India: a secondary analysis of a randomised controlled trial.

Objective: Large data on the clinical characteristics and outcome of COVID-19 in the Indian population are scarce. We analysed the factors associated with mortality in a cohort of moderately and severely ill patients with COVID-19 enrolled in a randomised trial on convalescent plasma.

Design: Secondary analysis of data from a Phase II, Open Label, Randomized Controlled Trial to Assess the Safety and Efficacy of Convalescent Plasma to Limit COVID-19 Associated Complications in Moderate Disease.

Clinical course and outcome of patients with COVID-19 in Mumbai City: an observational study.

Objective: To understand the outcome of hospitalised patients from Mumbai City, which had the highest number of COVID-19 cases in India.

Design: Observational study with follow-up.

Setting: Data extraction from medical records of patients with COVID-19 admitted to Nair Hospital & TN Medical College, Mumbai, India.

A two-arm, randomized, controlled, multi-centric, open-label phase-2 study to evaluate the efficacy and safety of Itolizumab in moderate to severe ARDS patients due to COVID-19.

: Efficacy and safety of Itolizumab, an immunomodulatory mAb, in treating moderate-to-severe acute respiratory distress syndrome (ARDS) due to cytokine release in COVID-19 patients was evaluated in a multi-centric, open-label, two-arm, controlled, randomized, phase-2 study.: Patients were randomized (2:1) to Arm-A (best supportive care [BSC]+Itolizumab) and Arm-B (BSC). Primary outcome of interest was reduction in mortality 30-days after enrollment.

Appraisal of Critically Ill COVID-19 Patients at a Dedicated COVID Hospital.

Purpose: To study the pattern of severe COVID-19 to reduce morbidity and mortality.

Methods: It was an observational cohort study for comprehensive clinical analysis of critically ill COVID-19 patients at a dedicated COVID public hospital.

Results: Total 373(13.

Thrombocytopenia in Pregnancy Nearing Term: A Clinical Analysis.

Background And Aim: Thrombocytopenia in pregnancy varies from benign to severe with fetomaternal complications. We aimed to evaluate thrombocytopenia in pregnant Indian females in third trimester mainly during labor and delivery.

Materials And Methods: It was a prospective observational study done in a tertiary care teaching public hospital over 1 year.

Analysis of Poisoning in Urban Setting: A Single Centre Study.

Background: Poisoning are common emergencies associated with high mortality and morbidity in India. This study aims to analyse the pattern of poisoning, clinico-epidemiological features, course and outcome of patients and factors affecting the outcome.

Methodology: This was an observational, prospective study conducted at a tertiary care, teaching, public, urban hospital.

Emerging trends of nosocomial pneumonia in intensive care unit of a tertiary care public teaching hospital in Western India.

Background: Nosocomial pneumonia poses great challenge to an intensivist. Detailed information about hospital-acquired pneumonia (HAP) and ventilator-acquired pneumonia (VAP) is crucial for prevention and optimal management, thus improving quality Intensive Care Unit (ICU) care. Hence, we aimed to study the current trend of nosocomial pneumonia in ICU.

A Prospective Study of Acute Kidney Injury According to KDIGO Definition and its Mortality Predictors.

Background: Acute kidney injury is no longer considered to be an innocent bystander merely reflecting co-existent pathologies but an independent risk factor for mortality in the ICU.

Aims And Objectives: To study clinical profile and correlation of patients with acute kidney injury (AKI) according to KDIGO definition with respect to incidence, outcome and different causes of AKI in critical care unit.

Study Design And Setting: It is a prospective observational study; and was carried out in the ICU of a tertiary care, teaching, public hospital.

Mortality Predictors of ARDS in Medical Intensive Care Unit of a Tertiary Care Centre in a Tropical Country.

Background: Acute respiratory distress syndrome (ARDS) is a clinical syndrome of severe dyspnoea of rapid onset, hypoxemia, and diffuse pulmonary infiltrates leading to respiratory failure in the absence of cardiac failure. We did the study to asses various aetiologies of ARDS, to determine the correlation between the diagnostic criteria, mortality predictors, need of mechanical ventilation and the outcome of patients. This was an observational, prospective study in medical intensive care unit (MICU) of a tertiary care hospital, over a period of 15 months.

Pediatric endoscopic dacryocystorhinostomy.

This is a case series with chart review from 1997 to 2010 to determine results of endoscopic dacryocystorhinostomy in children. Thirty-seven children underwent removal of the medial wall (RMW) of the lacrimal sac (LS) and 2 had lacrimal stents inserted because they had external fistulae and small cicatrized LS. Parameters of success were (1) resolution of epiphora, (2) no further attacks of dacryocystitis, and (3) patency of neofistula.